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- W3039657440 abstract "<b><i>Introduction:</i></b> In effusion cytology, mesothelial cells can occasionally present with striking intracytoplasmic accumulation of rod- and crystal-like cytoplasmic lamellar inclusions (LIs). Their nature and function are poorly understood, and their diagnostic relevance is unknown. <b><i>Objective:</i></b> The aim of this study was to explore the nature of LIs in mesothelial cells and determine their prevalence and diagnostic utility in routine practice. <b><i>Material and Method:</i></b> We reviewed a consecutive series of cytological specimens of reactive (<i>n</i> = 102) and malignant effusions (<i>n</i> = 90), respectively. Malignant effusions included malignant mesotheliomas (<i>n</i> = 63) and carcinomas (<i>n</i> = 27). LIs of one effusion were analyzed by electron microscopy (EM). <b><i>Results:</i></b> LIs were found exclusively in benign mesothelial cells in 14% (14/102) of reactive and in 4% (1/27) of malignant effusions with carcinomatosis. They were absent in effusions of malignant mesothelioma. EM revealed mainly straight lamellar, less tubular, structures in cisternae of the hyperplasic rough endoplasmic reticulum (rER). <b><i>Conclusion:</i></b> Cytoplasmic LIs located within hyperplastic rER can be found in up to 14% of effusions restricted to benign mesothelial cells. They can be used as an indirect morphological clue favoring the diagnosis of benign effusion and helping the cytologist to differentiate between reactive and malignant mesothelial cells in daily practice." @default.
- W3039657440 created "2020-07-10" @default.
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- W3039657440 date "2020-01-01" @default.
- W3039657440 modified "2023-10-14" @default.
- W3039657440 title "Lamellar Inclusions within Hyperplastic Endoplasmic Reticulum in Benign Mesothelial Cells" @default.
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- W3039657440 doi "https://doi.org/10.1159/000508757" @default.
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