FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039681908> ?p ?o ?g. }

• W3039681908 abstract "Abstract Deubiquitinating enzymes (DUBs) are important regulators of the posttranslational protein ubiquitination system. Mammalian genomes encode about hundred different DUBs, which can be grouped into seven different classes. Members of other DUB classes are found in pathogenic bacteria, which use them to target the host defense. By combining bioinformatical and experimental approaches, we address the question if the known DUB families have a common evolutionary ancestry and share conserved features that set them apart from other proteases. By systematically comparing family-specific Hidden-Markov-Models, we uncovered distant relationships between established DUBs and other cysteine protease families. Most DUB families share a conserved aromatic residue linked to the active site, which restricts the cleavage of substrates with sidechains at the S2 position, corresponding to Gly-75 in ubiquitin. By applying these criteria to Legionella pneumophila ORFs, we identified lpg1621 and lpg1148 as deubiquitinases, characterized their cleavage specificities, and confirmed the importance of the aromatic gatekeeper motif for substrate selection." @default.
• W3039681908 created "2020-07-10" @default.
• W3039681908 creator A5015309073 @default.
• W3039681908 creator A5015519563 @default.
• W3039681908 creator A5031918735 @default.
• W3039681908 creator A5033846293 @default.
• W3039681908 creator A5054371415 @default.
• W3039681908 creator A5067287697 @default.
• W3039681908 date "2020-07-01" @default.
• W3039681908 modified "2023-10-10" @default.
• W3039681908 title "An evolutionary approach to systematic discovery of novel deubiquitinases, applied to Legionella" @default.
• W3039681908 cites W1552171878 @default.
• W3039681908 cites W1966771851 @default.
• W3039681908 cites W1999264959 @default.
• W3039681908 cites W2032997281 @default.
• W3039681908 cites W2035151409 @default.
• W3039681908 cites W2035353973 @default.
• W3039681908 cites W2068621468 @default.
• W3039681908 cites W2095803950 @default.
• W3039681908 cites W2099598643 @default.
• W3039681908 cites W2103747393 @default.
• W3039681908 cites W2115214832 @default.
• W3039681908 cites W2119415370 @default.
• W3039681908 cites W2121465721 @default.
• W3039681908 cites W2145268834 @default.
• W3039681908 cites W2147917253 @default.
• W3039681908 cites W2156125289 @default.
• W3039681908 cites W2158359547 @default.
• W3039681908 cites W2159675211 @default.
• W3039681908 cites W2160378127 @default.
• W3039681908 cites W2162223351 @default.
• W3039681908 cites W2172667145 @default.
• W3039681908 cites W2409179396 @default.
• W3039681908 cites W2466579264 @default.
• W3039681908 cites W2516966698 @default.
• W3039681908 cites W2530082208 @default.
• W3039681908 cites W2566177767 @default.
• W3039681908 cites W2590813565 @default.
• W3039681908 cites W2613065881 @default.
• W3039681908 cites W2755866416 @default.
• W3039681908 cites W2769449671 @default.
• W3039681908 cites W2789665726 @default.
• W3039681908 cites W2790295680 @default.
• W3039681908 cites W2793122718 @default.
• W3039681908 cites W2889126774 @default.
• W3039681908 cites W2898232581 @default.
• W3039681908 cites W2914591999 @default.
• W3039681908 cites W2922956498 @default.
• W3039681908 cites W2954851300 @default.
• W3039681908 cites W2995511870 @default.
• W3039681908 cites W3000089338 @default.
• W3039681908 cites W3035797211 @default.
• W3039681908 cites W4210757594 @default.
• W3039681908 cites W4236236547 @default.
• W3039681908 cites W4255701985 @default.
• W3039681908 doi "https://doi.org/10.1101/2020.07.01.182683" @default.
• W3039681908 hasPublicationYear "2020" @default.
• W3039681908 type Work @default.
• W3039681908 sameAs 3039681908 @default.
• W3039681908 citedByCount "1" @default.
• W3039681908 countsByYear W30396819082023 @default.
• W3039681908 crossrefType "posted-content" @default.
• W3039681908 hasAuthorship W3039681908A5015309073 @default.
• W3039681908 hasAuthorship W3039681908A5015519563 @default.
• W3039681908 hasAuthorship W3039681908A5031918735 @default.
• W3039681908 hasAuthorship W3039681908A5033846293 @default.
• W3039681908 hasAuthorship W3039681908A5054371415 @default.
• W3039681908 hasAuthorship W3039681908A5067287697 @default.
• W3039681908 hasBestOaLocation W30396819081 @default.
• W3039681908 hasConcept C102658986 @default.
• W3039681908 hasConcept C104317684 @default.
• W3039681908 hasConcept C141231307 @default.
• W3039681908 hasConcept C151730666 @default.
• W3039681908 hasConcept C167625842 @default.
• W3039681908 hasConcept C175156509 @default.
• W3039681908 hasConcept C181199279 @default.
• W3039681908 hasConcept C182220744 @default.
• W3039681908 hasConcept C25602115 @default.
• W3039681908 hasConcept C2776118409 @default.
• W3039681908 hasConcept C2777283782 @default.
• W3039681908 hasConcept C2780530800 @default.
• W3039681908 hasConcept C43369102 @default.
• W3039681908 hasConcept C47289529 @default.
• W3039681908 hasConcept C523546767 @default.
• W3039681908 hasConcept C54355233 @default.
• W3039681908 hasConcept C55493867 @default.
• W3039681908 hasConcept C70721500 @default.
• W3039681908 hasConcept C86803240 @default.
• W3039681908 hasConceptScore W3039681908C102658986 @default.
• W3039681908 hasConceptScore W3039681908C104317684 @default.
• W3039681908 hasConceptScore W3039681908C141231307 @default.
• W3039681908 hasConceptScore W3039681908C151730666 @default.
• W3039681908 hasConceptScore W3039681908C167625842 @default.
• W3039681908 hasConceptScore W3039681908C175156509 @default.
• W3039681908 hasConceptScore W3039681908C181199279 @default.
• W3039681908 hasConceptScore W3039681908C182220744 @default.
• W3039681908 hasConceptScore W3039681908C25602115 @default.
• W3039681908 hasConceptScore W3039681908C2776118409 @default.
• W3039681908 hasConceptScore W3039681908C2777283782 @default.
• W3039681908 hasConceptScore W3039681908C2780530800 @default.

• next