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- W3039682829 endingPage "1595" @default.
- W3039682829 startingPage "1595" @default.
- W3039682829 abstract "The purinergic receptor P2Y6 is expressed in immune cells, including the microglia that are implicated in neurological disorders. Its ligand, UDP, is a signaling molecule that can serve as an “find-me” signal when released in significant quantities by damaged/dying cells. The binding of UDP by P2Y6R leads to the activation of different biochemical pathways, depending on the disease context and the pathological environment. Generally, P2Y6R stimulates phagocytosis. However, whether or not phagocytosis coincides with cell activation or the secretion of pro-inflammatory cytokines needs further investigation. The current review aims to discuss the various functions of P2Y6R in some CNS disorders. We present evidence that P2Y6R may have a detrimental or beneficial role in the nervous system, in the context of neurological pathologies, such as ischemic stroke, Alzheimer’s disease, Parkinson’s disease, radiation-induced brain injury, and neuropathic pain." @default.
- W3039682829 created "2020-07-10" @default.
- W3039682829 creator A5003602321 @default.
- W3039682829 creator A5027140673 @default.
- W3039682829 creator A5067657992 @default.
- W3039682829 date "2020-07-01" @default.
- W3039682829 modified "2023-10-02" @default.
- W3039682829 title "Microglia Purinoceptor P2Y6: An Emerging Therapeutic Target in CNS Diseases" @default.
- W3039682829 cites W1485797978 @default.
- W3039682829 cites W1486418814 @default.
- W3039682829 cites W1493677415 @default.
- W3039682829 cites W1521809539 @default.
- W3039682829 cites W1524986137 @default.
- W3039682829 cites W1532514630 @default.
- W3039682829 cites W1552322215 @default.
- W3039682829 cites W1768846296 @default.
- W3039682829 cites W1966466072 @default.
- W3039682829 cites W1967029213 @default.
- W3039682829 cites W1968444524 @default.
- W3039682829 cites W1970811141 @default.
- W3039682829 cites W1975025283 @default.
- W3039682829 cites W1975774284 @default.
- W3039682829 cites W1975857663 @default.
- W3039682829 cites W1986611577 @default.
- W3039682829 cites W1987465314 @default.
- W3039682829 cites W1989991560 @default.
- W3039682829 cites W1994395847 @default.
- W3039682829 cites W1995102677 @default.
- W3039682829 cites W2001958815 @default.
- W3039682829 cites W2002353628 @default.
- W3039682829 cites W2004696602 @default.
- W3039682829 cites W2006644445 @default.
- W3039682829 cites W2011221727 @default.
- W3039682829 cites W2012232274 @default.
- W3039682829 cites W2019070297 @default.
- W3039682829 cites W2025684895 @default.
- W3039682829 cites W2029162284 @default.
- W3039682829 cites W2030694434 @default.
- W3039682829 cites W2031080649 @default.
- W3039682829 cites W2036600670 @default.
- W3039682829 cites W2049275713 @default.
- W3039682829 cites W2051140555 @default.
- W3039682829 cites W2057310829 @default.
- W3039682829 cites W2063995449 @default.
- W3039682829 cites W2075465392 @default.
- W3039682829 cites W2078253393 @default.
- W3039682829 cites W2078323484 @default.
- W3039682829 cites W2081351019 @default.
- W3039682829 cites W2083566457 @default.
- W3039682829 cites W2087243986 @default.
- W3039682829 cites W2094522722 @default.
- W3039682829 cites W2096963202 @default.
- W3039682829 cites W2100452437 @default.
- W3039682829 cites W2104818454 @default.
- W3039682829 cites W2111425451 @default.
- W3039682829 cites W2118177585 @default.
- W3039682829 cites W2119767998 @default.
- W3039682829 cites W2120644885 @default.
- W3039682829 cites W2135919238 @default.
- W3039682829 cites W2139175045 @default.
- W3039682829 cites W2144648226 @default.
- W3039682829 cites W2149371927 @default.
- W3039682829 cites W2158404841 @default.
- W3039682829 cites W2159754384 @default.
- W3039682829 cites W2160220102 @default.
- W3039682829 cites W2190308692 @default.
- W3039682829 cites W2313950434 @default.
- W3039682829 cites W2317971631 @default.
- W3039682829 cites W2340464393 @default.
- W3039682829 cites W2590735667 @default.
- W3039682829 cites W2592378998 @default.
- W3039682829 cites W2592462728 @default.
- W3039682829 cites W2610627565 @default.
- W3039682829 cites W2621707445 @default.
- W3039682829 cites W2712068521 @default.
- W3039682829 cites W2734651019 @default.
- W3039682829 cites W2735527928 @default.
- W3039682829 cites W2735674855 @default.
- W3039682829 cites W2765290339 @default.
- W3039682829 cites W2786697307 @default.
- W3039682829 cites W2790464514 @default.
- W3039682829 cites W2796748561 @default.
- W3039682829 cites W2799815156 @default.
- W3039682829 cites W2808844732 @default.
- W3039682829 cites W2884536394 @default.
- W3039682829 cites W2887564896 @default.
- W3039682829 cites W2889106553 @default.
- W3039682829 cites W2898603548 @default.
- W3039682829 cites W2903201307 @default.
- W3039682829 cites W2904871119 @default.
- W3039682829 cites W2905070817 @default.
- W3039682829 cites W2912466497 @default.
- W3039682829 cites W2916913984 @default.
- W3039682829 cites W2944611348 @default.
- W3039682829 cites W2948897846 @default.
- W3039682829 cites W2958070288 @default.
- W3039682829 cites W2981768715 @default.
- W3039682829 cites W2983134909 @default.