FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039695430> ?p ?o ?g. }

• W3039695430 endingPage "6111" @default.
• W3039695430 startingPage "6103" @default.
• W3039695430 abstract "Oligodendrocyte myelination depends on actin cytoskeleton rearrangement. Neural Wiskott-Aldrich syndrome protein(N-Wasp) is an actin nucleation factor that promotes polymerization of branched actin filaments. N-Wasp activity is essential for myelin membrane wrapping by Schwann cells, but its role in oligodendrocytes and CNS myelination remains unknown. Here we report that oligodendrocytes-specific deletion of <i>N-Wasp</i> in mice of both sexes resulted in hypomyelination (i.e., reduced number of myelinated axons and thinner myelin profiles), as well as substantial focal hypermyelination reflected by the formation of remarkably long myelin outfolds. These myelin outfolds surrounded unmyelinated axons, neuronal cell bodies, and other myelin profiles. The latter configuration resulted in pseudo-multimyelin profiles that were often associated with axonal detachment and degeneration throughout the CNS, including in the optic nerve, corpus callosum, and the spinal cord. Furthermore, developmental analysis revealed that myelin abnormalities were already observed during the onset of myelination, suggesting that they are formed by aberrant and misguided elongation of the oligodendrocyte inner lip membrane. Our results demonstrate that N-Wasp is required for the formation of normal myelin in the CNS. They also reveal that N-Wasp plays a distinct role in oligodendrocytes compared with Schwann cells, highlighting a difference in the regulation of actin dynamics during CNS and PNS myelination. <b>SIGNIFICANCE STATEMENT</b> Myelin is critical for the normal function of the nervous system by facilitating fast conduction of action potentials. During the process of myelination in the CNS, oligodendrocytes undergo extensive morphological changes that involve cellular process extension and retraction, axonal ensheathment, and myelin membrane wrapping. Here we present evidence that N-Wasp, a protein regulating actin filament assembly through Arp2/3 complex-dependent actin nucleation, plays a critical role in CNS myelination, and its absence leads to several myelin abnormalities. Our data provide an important step into the understanding of the molecular mechanisms underlying CNS myelination." @default.
• W3039695430 created "2020-07-10" @default.
• W3039695430 creator A5002548869 @default.
• W3039695430 creator A5006212346 @default.
• W3039695430 creator A5009487029 @default.
• W3039695430 creator A5052010206 @default.
• W3039695430 creator A5054196091 @default.
• W3039695430 creator A5059683509 @default.
• W3039695430 date "2020-06-29" @default.
• W3039695430 modified "2023-10-18" @default.
• W3039695430 title "N-Wasp Regulates Oligodendrocyte Myelination" @default.
• W3039695430 cites W1519983393 @default.
• W3039695430 cites W1788586683 @default.
• W3039695430 cites W1839988640 @default.
• W3039695430 cites W1960862471 @default.
• W3039695430 cites W1973848776 @default.
• W3039695430 cites W1976433348 @default.
• W3039695430 cites W1988593586 @default.
• W3039695430 cites W1993748761 @default.
• W3039695430 cites W1997734809 @default.
• W3039695430 cites W2000485285 @default.
• W3039695430 cites W2002513784 @default.
• W3039695430 cites W2025301878 @default.
• W3039695430 cites W2041083111 @default.
• W3039695430 cites W2043967008 @default.
• W3039695430 cites W2048788946 @default.
• W3039695430 cites W2050991019 @default.
• W3039695430 cites W2053632281 @default.
• W3039695430 cites W2054275187 @default.
• W3039695430 cites W2056928450 @default.
• W3039695430 cites W2078531498 @default.
• W3039695430 cites W2091901955 @default.
• W3039695430 cites W2103650093 @default.
• W3039695430 cites W2114832016 @default.
• W3039695430 cites W2116747568 @default.
• W3039695430 cites W2124168697 @default.
• W3039695430 cites W2124940469 @default.
• W3039695430 cites W2139094884 @default.
• W3039695430 cites W2167279371 @default.
• W3039695430 cites W2280623042 @default.
• W3039695430 cites W2318427513 @default.
• W3039695430 cites W2415341492 @default.
• W3039695430 cites W2581904435 @default.
• W3039695430 cites W2663610293 @default.
• W3039695430 cites W2734706736 @default.
• W3039695430 cites W2802858545 @default.
• W3039695430 cites W2895829083 @default.
• W3039695430 cites W2905444337 @default.
• W3039695430 cites W2909041518 @default.
• W3039695430 cites W2920987148 @default.
• W3039695430 cites W2944786249 @default.
• W3039695430 cites W2970414022 @default.
• W3039695430 cites W2981614609 @default.
• W3039695430 cites W2989340324 @default.
• W3039695430 cites W2996695962 @default.
• W3039695430 cites W2996859213 @default.
• W3039695430 cites W3000982459 @default.
• W3039695430 doi "https://doi.org/10.1523/jneurosci.0912-20.2020" @default.
• W3039695430 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7406274" @default.
• W3039695430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32601246" @default.
• W3039695430 hasPublicationYear "2020" @default.
• W3039695430 type Work @default.
• W3039695430 sameAs 3039695430 @default.
• W3039695430 citedByCount "17" @default.
• W3039695430 countsByYear W30396954302021 @default.
• W3039695430 countsByYear W30396954302022 @default.
• W3039695430 countsByYear W30396954302023 @default.
• W3039695430 crossrefType "journal-article" @default.
• W3039695430 hasAuthorship W3039695430A5002548869 @default.
• W3039695430 hasAuthorship W3039695430A5006212346 @default.
• W3039695430 hasAuthorship W3039695430A5009487029 @default.
• W3039695430 hasAuthorship W3039695430A5052010206 @default.
• W3039695430 hasAuthorship W3039695430A5054196091 @default.
• W3039695430 hasAuthorship W3039695430A5059683509 @default.
• W3039695430 hasBestOaLocation W30396954301 @default.
• W3039695430 hasConcept C105702510 @default.
• W3039695430 hasConcept C169760540 @default.
• W3039695430 hasConcept C2776985911 @default.
• W3039695430 hasConcept C2778609137 @default.
• W3039695430 hasConcept C2779530196 @default.
• W3039695430 hasConcept C2780862704 @default.
• W3039695430 hasConcept C2780876595 @default.
• W3039695430 hasConcept C529278444 @default.
• W3039695430 hasConcept C86803240 @default.
• W3039695430 hasConcept C95444343 @default.
• W3039695430 hasConceptScore W3039695430C105702510 @default.
• W3039695430 hasConceptScore W3039695430C169760540 @default.
• W3039695430 hasConceptScore W3039695430C2776985911 @default.
• W3039695430 hasConceptScore W3039695430C2778609137 @default.
• W3039695430 hasConceptScore W3039695430C2779530196 @default.
• W3039695430 hasConceptScore W3039695430C2780862704 @default.
• W3039695430 hasConceptScore W3039695430C2780876595 @default.
• W3039695430 hasConceptScore W3039695430C529278444 @default.
• W3039695430 hasConceptScore W3039695430C86803240 @default.
• W3039695430 hasConceptScore W3039695430C95444343 @default.
• W3039695430 hasIssue "32" @default.
• W3039695430 hasLocation W30396954301 @default.
• W3039695430 hasLocation W30396954302 @default.

• next