FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039786422> ?p ?o ?g. }

• W3039786422 endingPage "8397" @default.
• W3039786422 startingPage "8388" @default.
• W3039786422 abstract "Exogenous molecules derived from catabolic states (e.g., fatty acids, β-hydroxybutyrate) during periods of stress such as the periparturient period or pathogen challenges [e.g., lipopolysaccharide (LPS)] can trigger an inflammatory response in tissues such as the liver and the mammary gland. Butyrate is one of the major short-chain fatty acids produced in the rumen, and work with non-ruminants has demonstrated that it can alter inflammatory processes. The primary objective of this study was to explore the preventive effect of sodium butyrate (SB) on LPS-induced inflammation in bovine mammary epithelial cells along with underlying molecular mechanisms. Immortalized bovine mammary epithelial cells (MAC-T) were treated with SB (0.1, 0.25, 0.5, 1, 2, or 5 mM) or with the histone deacetylase inhibitor trichostatin A (TSA; 6.25, 12.5, 25, or 50 nM) for 18 h, followed by a challenge with 1 µg/mL LPS for an additional 6 h. Pretreatment with SB prevented increase in apoptosis of LPS-challenged MAC-T cells in a dose-dependent manner. The LPS treatment upregulated mRNA abundance of tumor necrosis factor α (TNFA), interleukin-6 (IL6), and interleukin-1B (IL1B), whereas inhibition of histone deacetylase with TSA dampened this effect. More importantly, SB had clear dose-dependent effects on the inflammatory response by preventing upregulation of TNFA, IL6, and IL1B. Furthermore, pretreatment with TSA or SB attenuated the downregulation of histone H3 acetylation protein abundance induced by LPS. The greater ratio of p-IκB α/IκB α and p-p65/p65 protein abundance and the increase in nuclear localization of NF-κB p65 protein in response to LPS were attenuated by pretreatment with SB. Overall, the data indicated that exogenous SB alleviates mammary cell pro-inflammatory responses partly through post-translational mechanisms that diminish NF-κB signaling. Thus, the cytoprotective effect of SB against an inflammatory challenge might represent a preventive tool to help the mammary gland against pathogens such as those causing mastitis." @default.
• W3039786422 created "2020-07-10" @default.
• W3039786422 creator A5000867921 @default.
• W3039786422 creator A5015715832 @default.
• W3039786422 creator A5051587922 @default.
• W3039786422 creator A5052662001 @default.
• W3039786422 creator A5064249897 @default.
• W3039786422 creator A5067286717 @default.
• W3039786422 creator A5071722754 @default.
• W3039786422 creator A5078504589 @default.
• W3039786422 creator A5089744573 @default.
• W3039786422 creator A5090556916 @default.
• W3039786422 date "2020-09-01" @default.
• W3039786422 modified "2023-09-24" @default.
• W3039786422 title "Sodium butyrate reduces bovine mammary epithelial cell inflammatory responses induced by exogenous lipopolysaccharide, by inactivating NF-κB signaling" @default.
• W3039786422 cites W1965985248 @default.
• W3039786422 cites W1971948897 @default.
• W3039786422 cites W1975516847 @default.
• W3039786422 cites W1982013562 @default.
• W3039786422 cites W1987846907 @default.
• W3039786422 cites W1990896493 @default.
• W3039786422 cites W1992670654 @default.
• W3039786422 cites W1999405426 @default.
• W3039786422 cites W2010464165 @default.
• W3039786422 cites W2011303470 @default.
• W3039786422 cites W2027620167 @default.
• W3039786422 cites W2034666592 @default.
• W3039786422 cites W2047183047 @default.
• W3039786422 cites W2053509474 @default.
• W3039786422 cites W2061301377 @default.
• W3039786422 cites W2065639384 @default.
• W3039786422 cites W2114973943 @default.
• W3039786422 cites W2147921405 @default.
• W3039786422 cites W2148639799 @default.
• W3039786422 cites W2156729042 @default.
• W3039786422 cites W2160943316 @default.
• W3039786422 cites W2170812501 @default.
• W3039786422 cites W2260646036 @default.
• W3039786422 cites W2287500273 @default.
• W3039786422 cites W2559202109 @default.
• W3039786422 cites W2563324786 @default.
• W3039786422 cites W2744020929 @default.
• W3039786422 cites W2785076772 @default.
• W3039786422 cites W2787829232 @default.
• W3039786422 cites W2794786199 @default.
• W3039786422 cites W2806524634 @default.
• W3039786422 cites W2890178633 @default.
• W3039786422 cites W2947634269 @default.
• W3039786422 cites W2947702218 @default.
• W3039786422 cites W2975673471 @default.
• W3039786422 doi "https://doi.org/10.3168/jds.2020-18189" @default.
• W3039786422 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32622605" @default.
• W3039786422 hasPublicationYear "2020" @default.
• W3039786422 type Work @default.
• W3039786422 sameAs 3039786422 @default.
• W3039786422 citedByCount "27" @default.
• W3039786422 countsByYear W30397864222020 @default.
• W3039786422 countsByYear W30397864222021 @default.
• W3039786422 countsByYear W30397864222022 @default.
• W3039786422 countsByYear W30397864222023 @default.
• W3039786422 crossrefType "journal-article" @default.
• W3039786422 hasAuthorship W3039786422A5000867921 @default.
• W3039786422 hasAuthorship W3039786422A5015715832 @default.
• W3039786422 hasAuthorship W3039786422A5051587922 @default.
• W3039786422 hasAuthorship W3039786422A5052662001 @default.
• W3039786422 hasAuthorship W3039786422A5064249897 @default.
• W3039786422 hasAuthorship W3039786422A5067286717 @default.
• W3039786422 hasAuthorship W3039786422A5071722754 @default.
• W3039786422 hasAuthorship W3039786422A5078504589 @default.
• W3039786422 hasAuthorship W3039786422A5089744573 @default.
• W3039786422 hasAuthorship W3039786422A5090556916 @default.
• W3039786422 hasBestOaLocation W30397864221 @default.
• W3039786422 hasConcept C100544194 @default.
• W3039786422 hasConcept C104317684 @default.
• W3039786422 hasConcept C126322002 @default.
• W3039786422 hasConcept C127561419 @default.
• W3039786422 hasConcept C134018914 @default.
• W3039786422 hasConcept C153911025 @default.
• W3039786422 hasConcept C17991360 @default.
• W3039786422 hasConcept C185592680 @default.
• W3039786422 hasConcept C203014093 @default.
• W3039786422 hasConcept C2776914184 @default.
• W3039786422 hasConcept C2776979534 @default.
• W3039786422 hasConcept C2777865847 @default.
• W3039786422 hasConcept C2778305200 @default.
• W3039786422 hasConcept C2778754761 @default.
• W3039786422 hasConcept C2778942008 @default.
• W3039786422 hasConcept C55493867 @default.
• W3039786422 hasConcept C64927066 @default.
• W3039786422 hasConcept C71924100 @default.
• W3039786422 hasConcept C86803240 @default.
• W3039786422 hasConceptScore W3039786422C100544194 @default.
• W3039786422 hasConceptScore W3039786422C104317684 @default.
• W3039786422 hasConceptScore W3039786422C126322002 @default.
• W3039786422 hasConceptScore W3039786422C127561419 @default.
• W3039786422 hasConceptScore W3039786422C134018914 @default.
• W3039786422 hasConceptScore W3039786422C153911025 @default.
• W3039786422 hasConceptScore W3039786422C17991360 @default.

• next