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• W3039796867 endingPage "110029" @default.
• W3039796867 startingPage "110029" @default.
• W3039796867 abstract "Clinical and pre-clinical evidence demonstrates divergent psychotropic effects of THC vs. CBD. While THC can induce perceptual distortions and anxiogenic effects, CBD displays antipsychotic and anxiolytic properties. A key brain region responsible for regulation of cognition and affect, the medial prefrontal cortex (PFC), is strongly modulated by cannabinoids, suggesting that these dissociable THC/CBD-dependent effects may involve functional and molecular interplay within the PFC. The primary aim of this study was to investigate potential interactions and molecular substrates involved in PFC-mediated effects of THC and CBD on differential cognitive and affective behavioural processing. Male Sprague Dawley rats received intra-PFC microinfusions of THC, CBD or their combination, and tested in the latent inhibition paradigm, spontaneous oddity discrimination test, elevated T-maze and open field. To identify local, drug-induced molecular modulation in the PFC, PFC samples were collected and processed with Western Blotting. Intra-PFC THC induced strong panic-like responses that were counteracted with CBD. In contrast, CBD did not affect panic-like behaviours but blocked formation of associative fear memories and impaired latent inhibition and oddity discrimination performance. Interestingly, these CBD effects were dependent upon 5-HT1A receptor transmission but not influenced by THC co-administration. Moreover, THC induced robust phosphorylation of ERK1/2 that was prevented by CBD, while CBD decreased phosphorylation of p70S6K, independently of THC. These results suggest that intra-PFC infusion of THC promotes panic-like behaviour associated with increased ERK1/2 phosphorylation. In contrast, CBD impairs perceptive functions and latent inhibition via activation of 5-HT1A receptors and reduced phosphorylation of p70S6K." @default.
• W3039796867 created "2020-07-10" @default.
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• W3039796867 date "2021-01-01" @default.
• W3039796867 modified "2023-10-18" @default.
• W3039796867 title "THC and CBD produce divergent effects on perception and panic behaviours via distinct cortical molecular pathways" @default.
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• W3039796867 cites W1672475903 @default.
• W3039796867 cites W1945751328 @default.
• W3039796867 cites W1964167179 @default.
• W3039796867 cites W1969039995 @default.
• W3039796867 cites W1969305409 @default.
• W3039796867 cites W1971729987 @default.
• W3039796867 cites W1973952134 @default.
• W3039796867 cites W1986189394 @default.
• W3039796867 cites W1994186616 @default.
• W3039796867 cites W1995306046 @default.
• W3039796867 cites W1996278273 @default.
• W3039796867 cites W1996345484 @default.
• W3039796867 cites W2006242135 @default.
• W3039796867 cites W2007034249 @default.
• W3039796867 cites W2007090195 @default.
• W3039796867 cites W2007497521 @default.
• W3039796867 cites W2011291368 @default.
• W3039796867 cites W2013122919 @default.
• W3039796867 cites W2016005609 @default.
• W3039796867 cites W2026272048 @default.
• W3039796867 cites W2028932421 @default.
• W3039796867 cites W2029037648 @default.
• W3039796867 cites W2047067656 @default.
• W3039796867 cites W2049540001 @default.
• W3039796867 cites W2053805858 @default.
• W3039796867 cites W2054568286 @default.
• W3039796867 cites W2056521494 @default.
• W3039796867 cites W2056618440 @default.
• W3039796867 cites W2061745435 @default.
• W3039796867 cites W2065303371 @default.
• W3039796867 cites W2068391993 @default.
• W3039796867 cites W2070697863 @default.
• W3039796867 cites W2072152884 @default.
• W3039796867 cites W2075392294 @default.
• W3039796867 cites W2076020923 @default.
• W3039796867 cites W2085124039 @default.
• W3039796867 cites W2092855120 @default.
• W3039796867 cites W2095353831 @default.
• W3039796867 cites W2096516060 @default.
• W3039796867 cites W2130077296 @default.
• W3039796867 cites W2136860901 @default.
• W3039796867 cites W2138738238 @default.
• W3039796867 cites W2143845228 @default.
• W3039796867 cites W2144444435 @default.
• W3039796867 cites W2144625250 @default.
• W3039796867 cites W2151137320 @default.
• W3039796867 cites W2154678178 @default.
• W3039796867 cites W2155919382 @default.
• W3039796867 cites W2156305454 @default.
• W3039796867 cites W2161119575 @default.
• W3039796867 cites W2165429333 @default.
• W3039796867 cites W2175038742 @default.
• W3039796867 cites W2324278517 @default.
• W3039796867 cites W2346551421 @default.
• W3039796867 cites W2419957316 @default.
• W3039796867 cites W2510973659 @default.
• W3039796867 cites W2587632917 @default.
• W3039796867 cites W2750716611 @default.
• W3039796867 cites W2752020056 @default.
• W3039796867 cites W2753508364 @default.
• W3039796867 cites W2766804405 @default.
• W3039796867 cites W2773072410 @default.
• W3039796867 cites W2802417482 @default.
• W3039796867 cites W2870516394 @default.
• W3039796867 cites W2902364352 @default.
• W3039796867 cites W2903126961 @default.
• W3039796867 cites W2904576522 @default.
• W3039796867 cites W2918499786 @default.
• W3039796867 cites W2922897313 @default.
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• W3039796867 doi "https://doi.org/10.1016/j.pnpbp.2020.110029" @default.
• W3039796867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32623021" @default.
• W3039796867 hasPublicationYear "2021" @default.
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