FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039824324> ?p ?o ?g. }

• W3039824324 endingPage "e73" @default.
• W3039824324 startingPage "e63" @default.
• W3039824324 abstract "Immune cells are present in normal breast tissue and in breast carcinoma. The nature and distribution of the immune cell subtypes in these tissues are reviewed to promote a better understanding of their important role in breast cancer prevention and treatment. We conducted a review of the literature to define the type, location, distribution, and role of immune cells in normal breast tissue and in in situ and invasive breast cancer. Immune cells in normal breast tissue are located predominantly within the epithelial component in breast ductal lobules. Immune cell subtypes representing innate immunity (NK, CD68+, and CD11c+ cells) and adaptive immunity (most commonly CD8+, but CD4+ and CD20+ as well) are present; CD8+ cells are the most common subtype and are primarily effector memory cells. Immune cells may recognize neoantigens and endogenous and exogenous ligands and may serve in chronic inflammation and immunosurveillance. Progression to breast cancer is characterized by increased immune cell infiltrates in tumor parenchyma and stroma, including CD4+ and CD8+ granzyme B+ cytotoxic T cells, B cells, macrophages and dendritic cells. Tumor-infiltrating lymphocytes in breast cancer may serve as prognostic indicators for response to chemotherapy and for survival. Experimental strategies of adoptive transfer of breast tumor-infiltrating lymphocyte may allow regression of metastatic breast cancer and encourage development of innovative T-cell strategies for the immunotherapy of breast cancer. In conclusion, immune cells in breast tissues play an important role throughout breast carcinogenesis. An understanding of these roles has important implications for the prevention and the treatment of breast cancer." @default.
• W3039824324 created "2020-07-10" @default.
• W3039824324 creator A5059431700 @default.
• W3039824324 creator A5076219640 @default.
• W3039824324 date "2021-02-01" @default.
• W3039824324 modified "2023-10-18" @default.
• W3039824324 title "The Role of Immune Cells in Breast Tissue and Immunotherapy for the Treatment of Breast Cancer" @default.
• W3039824324 cites W1967647146 @default.
• W3039824324 cites W1976280893 @default.
• W3039824324 cites W1981480494 @default.
• W3039824324 cites W1988379927 @default.
• W3039824324 cites W2000272838 @default.
• W3039824324 cites W2000637574 @default.
• W3039824324 cites W2025822501 @default.
• W3039824324 cites W2031576122 @default.
• W3039824324 cites W2045295282 @default.
• W3039824324 cites W2045688706 @default.
• W3039824324 cites W2046560134 @default.
• W3039824324 cites W2051849615 @default.
• W3039824324 cites W2052160940 @default.
• W3039824324 cites W2085122193 @default.
• W3039824324 cites W2088564980 @default.
• W3039824324 cites W2092590786 @default.
• W3039824324 cites W2093350606 @default.
• W3039824324 cites W2096283457 @default.
• W3039824324 cites W2098683355 @default.
• W3039824324 cites W2118278569 @default.
• W3039824324 cites W2120431466 @default.
• W3039824324 cites W2134878729 @default.
• W3039824324 cites W2139788242 @default.
• W3039824324 cites W2140633375 @default.
• W3039824324 cites W2141487097 @default.
• W3039824324 cites W2143517917 @default.
• W3039824324 cites W2146146786 @default.
• W3039824324 cites W2148360798 @default.
• W3039824324 cites W2157058802 @default.
• W3039824324 cites W2161982171 @default.
• W3039824324 cites W2163369593 @default.
• W3039824324 cites W2163871197 @default.
• W3039824324 cites W2166311080 @default.
• W3039824324 cites W2188489669 @default.
• W3039824324 cites W2199589184 @default.
• W3039824324 cites W2237810057 @default.
• W3039824324 cites W2258196886 @default.
• W3039824324 cites W2260996817 @default.
• W3039824324 cites W2284024054 @default.
• W3039824324 cites W2345415641 @default.
• W3039824324 cites W2346853311 @default.
• W3039824324 cites W2395676613 @default.
• W3039824324 cites W2406415524 @default.
• W3039824324 cites W2466558384 @default.
• W3039824324 cites W2497875668 @default.
• W3039824324 cites W2524984108 @default.
• W3039824324 cites W2540499565 @default.
• W3039824324 cites W2553911386 @default.
• W3039824324 cites W2582095691 @default.
• W3039824324 cites W2595324091 @default.
• W3039824324 cites W2603418329 @default.
• W3039824324 cites W2604278061 @default.
• W3039824324 cites W2605621988 @default.
• W3039824324 cites W2611380550 @default.
• W3039824324 cites W2625498240 @default.
• W3039824324 cites W2626312449 @default.
• W3039824324 cites W2652151562 @default.
• W3039824324 cites W2734928468 @default.
• W3039824324 cites W2737898225 @default.
• W3039824324 cites W2744653597 @default.
• W3039824324 cites W2755271275 @default.
• W3039824324 cites W2763156288 @default.
• W3039824324 cites W2771978163 @default.
• W3039824324 cites W2782930756 @default.
• W3039824324 cites W2791308824 @default.
• W3039824324 cites W2793907310 @default.
• W3039824324 cites W2794522602 @default.
• W3039824324 cites W2805209851 @default.
• W3039824324 cites W2805724135 @default.
• W3039824324 cites W2806895459 @default.
• W3039824324 cites W2809205318 @default.
• W3039824324 cites W2810097927 @default.
• W3039824324 cites W2889634664 @default.
• W3039824324 cites W2897422388 @default.
• W3039824324 cites W2918688996 @default.
• W3039824324 cites W2937981811 @default.
• W3039824324 cites W2945057866 @default.
• W3039824324 cites W2947008122 @default.
• W3039824324 cites W2952904472 @default.
• W3039824324 cites W2971193829 @default.
• W3039824324 cites W2972798700 @default.
• W3039824324 cites W2979575610 @default.
• W3039824324 cites W2982449517 @default.
• W3039824324 cites W3006930853 @default.
• W3039824324 cites W3009169565 @default.
• W3039824324 cites W3013032681 @default.
• W3039824324 doi "https://doi.org/10.1016/j.clbc.2020.06.011" @default.
• W3039824324 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7775885" @default.
• W3039824324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32893093" @default.
• W3039824324 hasPublicationYear "2021" @default.
• W3039824324 type Work @default.

• next