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• W3039925860 abstract "Abstract Context Preeclampsia is a leading cardiovascular complication in pregnancy lacking effective diagnostic and treatment strategies. Objective To investigate the diagnostic and therapeutic target potential of the angiogenesis proteins, FK506-binding protein like (FKBPL) and CD44. Design and Intervention FKBPL and CD44 plasma concentration or placental expression were determined in women pre- or postdiagnosis of preeclampsia. Trophoblast and endothelial cell function was assessed following mesenchymal stem cell (MSC) treatment and in the context of FKBPL signaling. Settings and Participants Human samples prediagnosis (15 and 20 weeks of gestation; n ≥ 57), or postdiagnosis (n = 18 for plasma; n = 4 for placenta) of preeclampsia were used to determine FKBPL and CD44 levels, compared to healthy controls. Trophoblast or endothelial cells were exposed to low/high oxygen, and treated with MSC-conditioned media (MSC-CM) or a FKBPL overexpression plasmid. Main Outcome Measures Preeclampsia risk stratification and diagnostic potential of FKBPL and CD44 were investigated. MSC treatment effects and FKBPL-CD44 signaling in trophoblast and endothelial cells were assessed. Results The CD44/FKBPL ratio was reduced in placenta and plasma following clinical diagnosis of preeclampsia. At 20 weeks of gestation, a high plasma CD44/FKBPL ratio was independently associated with the 2.3-fold increased risk of preeclampsia (odds ratio = 2.3, 95% confidence interval [CI] 1.03-5.23, P = 0.04). In combination with high mean arterial blood pressure (&gt;82.5 mmHg), the risk further increased to 3.9-fold (95% CI 1.30-11.84, P = 0.016). Both hypoxia and MSC-based therapy inhibited FKBPL-CD44 signaling, enhancing cell angiogenesis. Conclusions The FKBPL-CD44 pathway appears to have a central role in the pathogenesis of preeclampsia, showing promising utilities for early diagnostic and therapeutic purposes." @default.
• W3039925860 created "2020-07-10" @default.
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• W3039925860 date "2020-07-03" @default.
• W3039925860 modified "2023-10-11" @default.
• W3039925860 title "Role of A Novel Angiogenesis FKBPL-CD44 Pathway in Preeclampsia Risk Stratification and Mesenchymal Stem Cell Treatment" @default.
• W3039925860 cites W1951164694 @default.
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• W3039925860 cites W1976600554 @default.
• W3039925860 cites W1978940943 @default.
• W3039925860 cites W1980625867 @default.
• W3039925860 cites W1987358907 @default.
• W3039925860 cites W1988938167 @default.
• W3039925860 cites W2013378128 @default.
• W3039925860 cites W2013818100 @default.
• W3039925860 cites W2017904618 @default.
• W3039925860 cites W2019113075 @default.
• W3039925860 cites W2019340101 @default.
• W3039925860 cites W2025371271 @default.
• W3039925860 cites W2025623420 @default.
• W3039925860 cites W2027648896 @default.
• W3039925860 cites W2029432061 @default.
• W3039925860 cites W2030927418 @default.
• W3039925860 cites W2050561859 @default.
• W3039925860 cites W2058361387 @default.
• W3039925860 cites W2059180764 @default.
• W3039925860 cites W2072177711 @default.
• W3039925860 cites W2073197497 @default.
• W3039925860 cites W2085996860 @default.
• W3039925860 cites W2103985017 @default.
• W3039925860 cites W2118352334 @default.
• W3039925860 cites W2163041215 @default.
• W3039925860 cites W2167049762 @default.
• W3039925860 cites W2168559361 @default.
• W3039925860 cites W2169559326 @default.
• W3039925860 cites W2233620853 @default.
• W3039925860 cites W2233974801 @default.
• W3039925860 cites W2281429363 @default.
• W3039925860 cites W272421710 @default.
• W3039925860 cites W2730504020 @default.
• W3039925860 cites W2734501585 @default.
• W3039925860 cites W2738449290 @default.
• W3039925860 cites W2750655291 @default.
• W3039925860 cites W2792447231 @default.
• W3039925860 cites W2800436909 @default.
• W3039925860 cites W2806500078 @default.
• W3039925860 cites W2886189266 @default.
• W3039925860 cites W2890016426 @default.
• W3039925860 cites W2890090190 @default.
• W3039925860 cites W2908020403 @default.
• W3039925860 cites W2938860032 @default.
• W3039925860 cites W2943635746 @default.
• W3039925860 cites W2962388486 @default.
• W3039925860 cites W2967820717 @default.
• W3039925860 cites W2972816378 @default.
• W3039925860 cites W2991054518 @default.
• W3039925860 cites W3016145272 @default.
• W3039925860 cites W301622561 @default.
• W3039925860 cites W4211051919 @default.
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• W3039925860 doi "https://doi.org/10.1210/clinem/dgaa403" @default.
• W3039925860 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7765643" @default.
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