Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039969088> ?p ?o ?g. }
- W3039969088 endingPage "10" @default.
- W3039969088 startingPage "1" @default.
- W3039969088 abstract "Previous studies have disclosed the antihyperuricemic effect of polydatin, a natural precursor of resveratrol; however, the mechanisms of action still remain elusive. The present study was undertaken to evaluate the therapeutic effects and the underlying mechanisms of polydatin on potassium oxonate-induced hyperuricemia in rats through metabonomic technology from a holistic view. Nuclear magnetic resonance (NMR) spectroscopy was applied to capture the metabolic changes in sera and urine collected from rats induced by hyperuricemia and polydatin treatment. With multivariate data analysis, significant metabolic perturbations were observed in hyperuricemic rats compared with the healthy controls. A total of eleven and six metabolites were identified as differential metabolites related to hyperuricemia in serum and urine of rats, respectively. The proposed pathways primarily included branched-chain amino acid (BCAA) metabolism, glycolysis, the tricarboxylic acid cycle, synthesis and degradation of ketone bodies, purine metabolism, and intestinal microflora metabolism. Additionally, some metabolites indicated the risk of renal injury induced by hyperuricemia. Polydatin significantly lowered the levels of serum uric acid, creatinine, and blood urea nitrogen and alleviated the abnormal metabolic status in hyperuricemic rats by partially restoring the balance of the perturbed metabolic pathways. Our findings shed light on the understanding of the pathophysiological process of hyperuricemia and provided a reference for revealing the metabolic mechanism produced by polydatin in the treatment of hyperuricemia." @default.
- W3039969088 created "2020-07-10" @default.
- W3039969088 creator A5016341425 @default.
- W3039969088 creator A5050507251 @default.
- W3039969088 creator A5085643062 @default.
- W3039969088 creator A5085840076 @default.
- W3039969088 creator A5063221229 @default.
- W3039969088 date "2020-07-06" @default.
- W3039969088 modified "2023-10-12" @default.
- W3039969088 title "NMR-Based Metabonomic Study Reveals Intervention Effects of Polydatin on Potassium Oxonate-Induced Hyperuricemia in Rats" @default.
- W3039969088 cites W1236395005 @default.
- W3039969088 cites W1968813633 @default.
- W3039969088 cites W1985969855 @default.
- W3039969088 cites W1988871656 @default.
- W3039969088 cites W1991428500 @default.
- W3039969088 cites W1993196325 @default.
- W3039969088 cites W2010338089 @default.
- W3039969088 cites W2010413317 @default.
- W3039969088 cites W2018740887 @default.
- W3039969088 cites W2043626151 @default.
- W3039969088 cites W2051203009 @default.
- W3039969088 cites W2065569607 @default.
- W3039969088 cites W2092683461 @default.
- W3039969088 cites W2107419879 @default.
- W3039969088 cites W2112496211 @default.
- W3039969088 cites W2132218086 @default.
- W3039969088 cites W2167543906 @default.
- W3039969088 cites W2172649264 @default.
- W3039969088 cites W2296905828 @default.
- W3039969088 cites W2297096502 @default.
- W3039969088 cites W2338627428 @default.
- W3039969088 cites W2493615805 @default.
- W3039969088 cites W2508739135 @default.
- W3039969088 cites W2525149912 @default.
- W3039969088 cites W2589364187 @default.
- W3039969088 cites W2604417649 @default.
- W3039969088 cites W2673132246 @default.
- W3039969088 cites W2740120699 @default.
- W3039969088 cites W2749122470 @default.
- W3039969088 cites W2767003777 @default.
- W3039969088 cites W2805071249 @default.
- W3039969088 cites W2885647614 @default.
- W3039969088 cites W2886109576 @default.
- W3039969088 cites W2890217985 @default.
- W3039969088 cites W2898215373 @default.
- W3039969088 cites W2900967890 @default.
- W3039969088 cites W2925190816 @default.
- W3039969088 cites W2936763250 @default.
- W3039969088 cites W2942768033 @default.
- W3039969088 cites W2945582641 @default.
- W3039969088 cites W2947316660 @default.
- W3039969088 cites W2954435361 @default.
- W3039969088 cites W2970997773 @default.
- W3039969088 cites W2982684359 @default.
- W3039969088 cites W3009996881 @default.
- W3039969088 cites W787482168 @default.
- W3039969088 doi "https://doi.org/10.1155/2020/6943860" @default.
- W3039969088 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7362289" @default.
- W3039969088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32695259" @default.
- W3039969088 hasPublicationYear "2020" @default.
- W3039969088 type Work @default.
- W3039969088 sameAs 3039969088 @default.
- W3039969088 citedByCount "23" @default.
- W3039969088 countsByYear W30399690882021 @default.
- W3039969088 countsByYear W30399690882022 @default.
- W3039969088 countsByYear W30399690882023 @default.
- W3039969088 crossrefType "journal-article" @default.
- W3039969088 hasAuthorship W3039969088A5016341425 @default.
- W3039969088 hasAuthorship W3039969088A5050507251 @default.
- W3039969088 hasAuthorship W3039969088A5063221229 @default.
- W3039969088 hasAuthorship W3039969088A5085643062 @default.
- W3039969088 hasAuthorship W3039969088A5085840076 @default.
- W3039969088 hasBestOaLocation W30399690881 @default.
- W3039969088 hasConcept C126322002 @default.
- W3039969088 hasConcept C134018914 @default.
- W3039969088 hasConcept C185592680 @default.
- W3039969088 hasConcept C192989942 @default.
- W3039969088 hasConcept C21565614 @default.
- W3039969088 hasConcept C2777468819 @default.
- W3039969088 hasConcept C2777477808 @default.
- W3039969088 hasConcept C2779721657 @default.
- W3039969088 hasConcept C2779881121 @default.
- W3039969088 hasConcept C2779896295 @default.
- W3039969088 hasConcept C2780026642 @default.
- W3039969088 hasConcept C2780306776 @default.
- W3039969088 hasConcept C43617362 @default.
- W3039969088 hasConcept C515207424 @default.
- W3039969088 hasConcept C55493867 @default.
- W3039969088 hasConcept C62231903 @default.
- W3039969088 hasConcept C71924100 @default.
- W3039969088 hasConcept C77061444 @default.
- W3039969088 hasConcept C98274493 @default.
- W3039969088 hasConceptScore W3039969088C126322002 @default.
- W3039969088 hasConceptScore W3039969088C134018914 @default.
- W3039969088 hasConceptScore W3039969088C185592680 @default.
- W3039969088 hasConceptScore W3039969088C192989942 @default.
- W3039969088 hasConceptScore W3039969088C21565614 @default.
- W3039969088 hasConceptScore W3039969088C2777468819 @default.