Matches in SemOpenAlex for { <https://semopenalex.org/work/W3040052008> ?p ?o ?g. }
- W3040052008 abstract "Sarcoidosis and uveitis are chronic inflammatory conditions with potentially debilitating effects on quality of life. Steroids form the mainstay standard therapy in both conditions. Biologic agents are considered to be appropriate alternatives for treatment in steroid-refractory sarcoidosis and uveitis due to the role of tumor necrosis factor (TNF) in mediating the inflammatory cascade seen in both conditions. We performed a thorough literature search using PubMed to compare the extent of use, efficacy, and safety profile of individual anti-TNF agents in the management of these conditions. Our review consists of two systematic reviews with meta-analysis, thirteen observational studies, and fifteen case series/reports. Infliximab had the widest range of organ-system usage in extra-pulmonary sarcoidosis but is equivalent to adalimumab in terms of efficacy. In uveitis, adalimumab was found to be the most efficacious agent for maintaining disease remission in adults and children with chronic non-infectious uveitis. Etanercept was neither used widely, nor was it efficacious in the management of either condition. In terms of safety profile, biologic agents were found to be well tolerated and have a similar safety profile. More randomized clinical trials are needed to inform evidence-based use of biologic agents in these conditions." @default.
- W3040052008 created "2020-07-10" @default.
- W3040052008 creator A5045874642 @default.
- W3040052008 creator A5058681336 @default.
- W3040052008 creator A5079857436 @default.
- W3040052008 creator A5087994426 @default.
- W3040052008 creator A5091402179 @default.
- W3040052008 date "2020-07-07" @default.
- W3040052008 modified "2023-10-04" @default.
- W3040052008 title "Biologic Therapies in Sarcoidosis and Uveitis: A Review" @default.
- W3040052008 cites W1514234789 @default.
- W3040052008 cites W1530431523 @default.
- W3040052008 cites W1984188767 @default.
- W3040052008 cites W2006195897 @default.
- W3040052008 cites W2008468448 @default.
- W3040052008 cites W2049560208 @default.
- W3040052008 cites W2054650264 @default.
- W3040052008 cites W2088895989 @default.
- W3040052008 cites W2094921964 @default.
- W3040052008 cites W2096380177 @default.
- W3040052008 cites W2098035086 @default.
- W3040052008 cites W2112901522 @default.
- W3040052008 cites W2117666935 @default.
- W3040052008 cites W2136811009 @default.
- W3040052008 cites W2139683573 @default.
- W3040052008 cites W2142184645 @default.
- W3040052008 cites W2142277062 @default.
- W3040052008 cites W2156552575 @default.
- W3040052008 cites W2160986349 @default.
- W3040052008 cites W2169804326 @default.
- W3040052008 cites W2302672524 @default.
- W3040052008 cites W2335307438 @default.
- W3040052008 cites W2499246258 @default.
- W3040052008 cites W2510021462 @default.
- W3040052008 cites W2517470674 @default.
- W3040052008 cites W2521793746 @default.
- W3040052008 cites W2524065868 @default.
- W3040052008 cites W2550219652 @default.
- W3040052008 cites W2587342278 @default.
- W3040052008 cites W2620055410 @default.
- W3040052008 cites W2764110357 @default.
- W3040052008 cites W2765271240 @default.
- W3040052008 cites W2884751486 @default.
- W3040052008 cites W2888997593 @default.
- W3040052008 cites W2902891962 @default.
- W3040052008 cites W2910843288 @default.
- W3040052008 cites W2945866604 @default.
- W3040052008 cites W2951912926 @default.
- W3040052008 cites W2971934710 @default.
- W3040052008 cites W3024160555 @default.
- W3040052008 cites W4231140431 @default.
- W3040052008 doi "https://doi.org/10.7759/cureus.9057" @default.
- W3040052008 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7413313" @default.
- W3040052008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32782876" @default.
- W3040052008 hasPublicationYear "2020" @default.
- W3040052008 type Work @default.
- W3040052008 sameAs 3040052008 @default.
- W3040052008 citedByCount "1" @default.
- W3040052008 countsByYear W30400520082023 @default.
- W3040052008 crossrefType "journal-article" @default.
- W3040052008 hasAuthorship W3040052008A5045874642 @default.
- W3040052008 hasAuthorship W3040052008A5058681336 @default.
- W3040052008 hasAuthorship W3040052008A5079857436 @default.
- W3040052008 hasAuthorship W3040052008A5087994426 @default.
- W3040052008 hasAuthorship W3040052008A5091402179 @default.
- W3040052008 hasBestOaLocation W30400520081 @default.
- W3040052008 hasConcept C126322002 @default.
- W3040052008 hasConcept C16005928 @default.
- W3040052008 hasConcept C17744445 @default.
- W3040052008 hasConcept C177713679 @default.
- W3040052008 hasConcept C17991360 @default.
- W3040052008 hasConcept C189708586 @default.
- W3040052008 hasConcept C197934379 @default.
- W3040052008 hasConcept C199539241 @default.
- W3040052008 hasConcept C203014093 @default.
- W3040052008 hasConcept C23131810 @default.
- W3040052008 hasConcept C2776194053 @default.
- W3040052008 hasConcept C2777138892 @default.
- W3040052008 hasConcept C2777226972 @default.
- W3040052008 hasConcept C2779473830 @default.
- W3040052008 hasConcept C2780132546 @default.
- W3040052008 hasConcept C2781301800 @default.
- W3040052008 hasConcept C3018359032 @default.
- W3040052008 hasConcept C535046627 @default.
- W3040052008 hasConcept C71924100 @default.
- W3040052008 hasConceptScore W3040052008C126322002 @default.
- W3040052008 hasConceptScore W3040052008C16005928 @default.
- W3040052008 hasConceptScore W3040052008C17744445 @default.
- W3040052008 hasConceptScore W3040052008C177713679 @default.
- W3040052008 hasConceptScore W3040052008C17991360 @default.
- W3040052008 hasConceptScore W3040052008C189708586 @default.
- W3040052008 hasConceptScore W3040052008C197934379 @default.
- W3040052008 hasConceptScore W3040052008C199539241 @default.
- W3040052008 hasConceptScore W3040052008C203014093 @default.
- W3040052008 hasConceptScore W3040052008C23131810 @default.
- W3040052008 hasConceptScore W3040052008C2776194053 @default.
- W3040052008 hasConceptScore W3040052008C2777138892 @default.
- W3040052008 hasConceptScore W3040052008C2777226972 @default.
- W3040052008 hasConceptScore W3040052008C2779473830 @default.
- W3040052008 hasConceptScore W3040052008C2780132546 @default.