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• W3040073721 abstract "<b><i>Introduction:</i></b> Persistent infection with high-risk human papillomavirus (HPV) types is associated with high-grade intraepithelial lesions (HSILs) and invasive cervical cancer. The host immune response plays a key role in whether HPV clears or persists. Most studies on local immune response to HPV collect cervical mucus in order to quantify secreted cytokines; however, cells located inside the tissue can release different cytokines associated with HPV infection. <b><i>Objective:</i></b> This study compared the cytokine levels in cervical biopsy specimens of women with abnormal colposcopic findings according to the histopathological results: low-grade intraepithelial lesion (LSIL), HSIL, and no intraepithelial lesion (NSIL). <b><i>Methods:</i></b> A cross-sectional study enrolling 141 cervical biopsy specimens examined the cytokine profile for interleukin (IL-) 2, IL-4, IL-10, IL-12, IL-17, and IL-23 and interferon-γ, using the Luminex assay/ELISA. Differences in cytokine levels among the cervical lesion groups were assessed using the Kruskal-Wallis test. <b><i>Results:</i></b> The 141 specimens included 90 HSILs, 22 LSILs, and 29 NSILs. IL-2 levels were significantly higher in NSIL samples than in LSIL or in HSIL samples (<i>p</i> = 0.0001) and IL-23 levels were significantly higher in NSIL than in HSIL samples (<i>p</i> = 0.003). <b><i>Conclusions:</i></b> Our study shows that in samples from the lesion site point, 2 important pro-inflammatory cytokines, IL-2 and IL-23, are downregulated in HPV lesions." @default.
• W3040073721 created "2020-07-10" @default.
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• W3040073721 date "2020-01-01" @default.
• W3040073721 modified "2023-10-16" @default.
• W3040073721 title "Downregulation of IL-2 and IL-23 in Cervical Biopsies of Cervical Intraepithelial Lesions: A Cross-Sectional Study" @default.
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• W3040073721 doi "https://doi.org/10.1159/000508015" @default.
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