Matches in SemOpenAlex for { <https://semopenalex.org/work/W3040176170> ?p ?o ?g. }
- W3040176170 abstract "ABSTRACT Autophagy is a conserved process that recycles cellular contents to promote survival. Although nitrogen starvation is the canonical inducer of autophagy, recent studies have revealed several other nutrients important to this process. In this study, we used a quantitative, high-throughput assay to identify potassium starvation as a new and potent inducer of autophagy. We found that potassium-dependent autophagy requires the core pathway kinases Atg1, Atg5, Vps34, as well as other components of Phosphatidylinositol 3-kinase Complex I. Transmission electron microscopy revealed abundant autophagosome formation in response to both stimuli. RNA sequencing indicated distinct transcriptional responses – nitrogen affects transport of ions such as copper while potassium targets the organization of other cellular components. Thus, nitrogen and potassium share the ability to influence metabolic supply and demand but do so in different ways. Both inputs promote catabolism through bulk autophagy, but inhibit cellular anabolism through distinct mechanisms." @default.
- W3040176170 created "2020-07-10" @default.
- W3040176170 creator A5021318279 @default.
- W3040176170 creator A5036992229 @default.
- W3040176170 creator A5054063002 @default.
- W3040176170 creator A5055265504 @default.
- W3040176170 creator A5061084605 @default.
- W3040176170 creator A5062893935 @default.
- W3040176170 creator A5070014350 @default.
- W3040176170 date "2020-07-01" @default.
- W3040176170 modified "2023-09-25" @default.
- W3040176170 title "Potassium starvation induces autophagy in yeast" @default.
- W3040176170 cites W115026104 @default.
- W3040176170 cites W1497366555 @default.
- W3040176170 cites W1519084876 @default.
- W3040176170 cites W1536638573 @default.
- W3040176170 cites W1555054913 @default.
- W3040176170 cites W1555546321 @default.
- W3040176170 cites W1792305319 @default.
- W3040176170 cites W1850687781 @default.
- W3040176170 cites W1920840680 @default.
- W3040176170 cites W1923816168 @default.
- W3040176170 cites W1932339177 @default.
- W3040176170 cites W1967085696 @default.
- W3040176170 cites W1969434123 @default.
- W3040176170 cites W1969971911 @default.
- W3040176170 cites W1972037002 @default.
- W3040176170 cites W1979228758 @default.
- W3040176170 cites W1985046929 @default.
- W3040176170 cites W1989136135 @default.
- W3040176170 cites W1991864822 @default.
- W3040176170 cites W1992571341 @default.
- W3040176170 cites W1998871484 @default.
- W3040176170 cites W2006393063 @default.
- W3040176170 cites W2013131355 @default.
- W3040176170 cites W2017028262 @default.
- W3040176170 cites W2020179522 @default.
- W3040176170 cites W2035631017 @default.
- W3040176170 cites W2036057911 @default.
- W3040176170 cites W2036818036 @default.
- W3040176170 cites W2039632321 @default.
- W3040176170 cites W2039688071 @default.
- W3040176170 cites W2041797933 @default.
- W3040176170 cites W2042843495 @default.
- W3040176170 cites W2045508653 @default.
- W3040176170 cites W2047802226 @default.
- W3040176170 cites W2052778323 @default.
- W3040176170 cites W2055064168 @default.
- W3040176170 cites W2062867942 @default.
- W3040176170 cites W2067272457 @default.
- W3040176170 cites W2070658923 @default.
- W3040176170 cites W2073963703 @default.
- W3040176170 cites W2074204387 @default.
- W3040176170 cites W2074397923 @default.
- W3040176170 cites W2079588007 @default.
- W3040176170 cites W2080093026 @default.
- W3040176170 cites W2089695512 @default.
- W3040176170 cites W2090013807 @default.
- W3040176170 cites W2092376816 @default.
- W3040176170 cites W2100605768 @default.
- W3040176170 cites W2103421087 @default.
- W3040176170 cites W2104714210 @default.
- W3040176170 cites W2108467072 @default.
- W3040176170 cites W2114371461 @default.
- W3040176170 cites W2115197624 @default.
- W3040176170 cites W2116056961 @default.
- W3040176170 cites W2119851117 @default.
- W3040176170 cites W2121292998 @default.
- W3040176170 cites W2126801593 @default.
- W3040176170 cites W2127911529 @default.
- W3040176170 cites W2131094572 @default.
- W3040176170 cites W2142962556 @default.
- W3040176170 cites W2143367055 @default.
- W3040176170 cites W2147056438 @default.
- W3040176170 cites W2149771125 @default.
- W3040176170 cites W2150856219 @default.
- W3040176170 cites W2154046032 @default.
- W3040176170 cites W2158611340 @default.
- W3040176170 cites W2159007909 @default.
- W3040176170 cites W2159035725 @default.
- W3040176170 cites W2163498098 @default.
- W3040176170 cites W2165054897 @default.
- W3040176170 cites W2167279371 @default.
- W3040176170 cites W2169456326 @default.
- W3040176170 cites W2169805130 @default.
- W3040176170 cites W2170110472 @default.
- W3040176170 cites W2179438025 @default.
- W3040176170 cites W2484914234 @default.
- W3040176170 cites W2485613725 @default.
- W3040176170 cites W2557469998 @default.
- W3040176170 cites W2592811885 @default.
- W3040176170 cites W2594744254 @default.
- W3040176170 cites W2602766066 @default.
- W3040176170 cites W2611401896 @default.
- W3040176170 cites W2752326209 @default.
- W3040176170 cites W2765927213 @default.
- W3040176170 cites W2891033524 @default.
- W3040176170 cites W2938579578 @default.
- W3040176170 cites W2940458413 @default.
- W3040176170 cites W2967850494 @default.