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- W3040197269 endingPage "R194" @default.
- W3040197269 startingPage "R187" @default.
- W3040197269 abstract "Hyperglycemia is the consequence of blood glucose dysregulation and a driving force of diabetic complications including retinopathy, nephropathy and cardiovascular diseases. The serum and glucocorticoid inducible kinase-1 (SGK1) has been suggested in the modulation of various pathophysiological activities. However, the role of SGK1 in blood glucose homeostasis remains less appreciated. In this review, we intend to summarize the function of SGK1 in glucose level regulation and to examine the evidence supporting the therapeutic potential of SGK1 inhibitors in hyperglycemia. Ample evidence points to the controversial roles of SGK1 in pancreatic insulin secretion and peripheral insulin sensitivity, which reflects the complex interplay between SGK1 activation and blood glucose fluctuation. Furthermore, SGK1 is engaged in glucose absorption and excretion in intestine and kidney and participates in the progression of hyperglycemia-induced secondary organ damage. As a net effect, blockage of SGK1 activation via either pharmacological inhibition or genetic manipulation seems to be helpful in glucose control at varying diabetic stages." @default.
- W3040197269 created "2020-07-10" @default.
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- W3040197269 date "2020-07-01" @default.
- W3040197269 modified "2023-10-10" @default.
- W3040197269 title "The functional duality of SGK1 in the regulation of hyperglycemia" @default.
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- W3040197269 doi "https://doi.org/10.1530/ec-20-0225" @default.
- W3040197269 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7424354" @default.
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- W3040197269 hasPublicationYear "2020" @default.
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