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- W3040269512 endingPage "226" @default.
- W3040269512 startingPage "210" @default.
- W3040269512 abstract "Messenger RNA and small interfering RNA are attractive modalities for curing diseases by complementation or knock-down of proteins. For success of these RNAs, a drug delivery system (DDS) is required to control a pharmacokinetics, to enhance cellular uptake, to overcome biological membranes, and to release the cargo into the cytoplasm. Based on past research, developing nanoparticles that are neutrally charged have been the mainstream of their development. Also, the materials are further mounted with pH- and/or reducing environment-responsive units. In this review, we summarize progress made in the molecular design of these materials. We also focus on the importance of the hydrophobic scaffold for tissue/cell targeting, intracellular trafficking, and immune responses. As a practical example, the design concept of the SS-cleavable and pH-activated lipid-like material (ssPalm) and subsequent molecular modification tailored to the RNA-based medical application is discussed." @default.
- W3040269512 created "2020-07-10" @default.
- W3040269512 creator A5010295108 @default.
- W3040269512 creator A5015662992 @default.
- W3040269512 creator A5060342489 @default.
- W3040269512 creator A5089871113 @default.
- W3040269512 date "2020-01-01" @default.
- W3040269512 modified "2023-10-03" @default.
- W3040269512 title "Development of lipid-like materials for RNA delivery based on intracellular environment-responsive membrane destabilization and spontaneous collapse" @default.
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