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• W3040287583 endingPage "4663" @default.
• W3040287583 startingPage "4663" @default.
• W3040287583 abstract "Despite combined antiretroviral therapy (ART) achieving efficient HIV replication control, HIV-associated neurocognitive disorders (HAND) continue to be highly prevalent in HIV-infected patients. Diabetes mellitus (DM) is a well-known comorbidity of HAND in HIV-infected patients. Blood brain barrier (BBB) dysfunction has been linked recently to dementia development, specifically in DM patients. BBB injury exists both in HIV and DM, likely contributing to cognitive decline. However, its extent, exact cellular targets and mechanisms are largely unknown. In this report, we found a decrease in pericyte coverage and expression of tight junction proteins in human brain tissues from HIV patients with DM and evidence of HAND when compared to HIV-infected patients without DM or seronegative DM patients. Using our in vitro BBB models, we demonstrated diminution of barrier integrity, enhanced monocyte adhesion, changes in cytoskeleton and overexpression of adhesion molecules in primary human brain endothelial cells or human brain pericytes after exposure to HIV and DM-relevant stimuli. Our study demonstrates for the first-time evidence of impaired BBB function in HIV-DM patients and shows potential mechanisms leading to it in brain endothelium and pericytes that may result in poorer cognitive performance compared to individuals without HIV and DM." @default.
• W3040287583 created "2020-07-10" @default.
• W3040287583 creator A5000385744 @default.
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• W3040287583 creator A5057472361 @default.
• W3040287583 creator A5063696047 @default.
• W3040287583 creator A5066495538 @default.
• W3040287583 date "2020-06-30" @default.
• W3040287583 modified "2023-10-06" @default.
• W3040287583 title "Combination of HIV-1 and Diabetes Enhances Blood Brain Barrier Injury via Effects on Brain Endothelium and Pericytes" @default.
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• W3040287583 doi "https://doi.org/10.3390/ijms21134663" @default.
• W3040287583 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7370277" @default.
• W3040287583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32630025" @default.
• W3040287583 hasPublicationYear "2020" @default.
• W3040287583 type Work @default.
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