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• W3040290377 startingPage "4737" @default.
• W3040290377 abstract "Hepatic fibrosis has been associated with a series of pathophysiological processes causing excessive accumulation of extracellular matrix proteins. Several cellular processes and molecular mechanisms have been implicated in the diseased liver that augments fibrogenesis, fibrogenic cytokines and associated liver complications. Liver biopsy remains an essential diagnostic tool for histological evaluation of hepatic fibrosis to establish a prognosis. In addition to being invasive, this methodology presents with several limitations including poor cost-effectiveness, prolonged hospitalizations, and risks of peritoneal bleeding, while the clinical use of this method does not reveal underlying pathogenic mechanisms. Several alternate noninvasive diagnostic strategies have been developed, to determine the extent of hepatic fibrosis, including the use of direct and indirect biomarkers. Immediate diagnosis of hepatic fibrosis by noninvasive means would be more palatable than a biopsy and could assist clinicians in taking early interventions timely, avoiding fatal complications, and improving prognosis. Therefore, we sought to review some common biomarkers of liver fibrosis along with some emerging candidates, including the oxidative stress-mediated biomarkers, epigenetic and genetic markers, exosomes, and miRNAs that needs further evaluation and would have better sensitivity and specificity. We also aim to elucidate the potential role of cardiotonic steroids (CTS) and evaluate the pro-inflammatory and profibrotic effects of CTS in exacerbating hepatic fibrosis. By understanding the underlying pathogenic processes, the efficacy of these biomarkers could allow for early diagnosis and treatment of hepatic fibrosis in chronic liver diseases, once validated." @default.
• W3040290377 created "2020-07-10" @default.
• W3040290377 creator A5005428451 @default.
• W3040290377 creator A5019242155 @default.
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• W3040290377 creator A5034909059 @default.
• W3040290377 creator A5041374756 @default.
• W3040290377 creator A5058934067 @default.
• W3040290377 date "2020-07-03" @default.
• W3040290377 modified "2023-09-27" @default.
• W3040290377 title "Elucidating Potential Profibrotic Mechanisms of Emerging Biomarkers for Early Prognosis of Hepatic Fibrosis" @default.
• W3040290377 cites W1240237824 @default.
• W3040290377 cites W1505584712 @default.
• W3040290377 cites W1506003080 @default.
• W3040290377 cites W1506582172 @default.
• W3040290377 cites W1925659448 @default.
• W3040290377 cites W1965090514 @default.
• W3040290377 cites W1965588383 @default.
• W3040290377 cites W1968760271 @default.
• W3040290377 cites W1971124766 @default.
• W3040290377 cites W1974605130 @default.
• W3040290377 cites W1980325398 @default.
• W3040290377 cites W1983251505 @default.
• W3040290377 cites W1983663108 @default.
• W3040290377 cites W1988228894 @default.
• W3040290377 cites W1990051101 @default.
• W3040290377 cites W1990329052 @default.
• W3040290377 cites W1996266503 @default.
• W3040290377 cites W1997474235 @default.
• W3040290377 cites W1999449196 @default.
• W3040290377 cites W1999700055 @default.
• W3040290377 cites W2000369852 @default.
• W3040290377 cites W2001247235 @default.
• W3040290377 cites W2001302249 @default.
• W3040290377 cites W2002596137 @default.
• W3040290377 cites W2005119615 @default.
• W3040290377 cites W2008695007 @default.
• W3040290377 cites W2010101404 @default.
• W3040290377 cites W2019108167 @default.
• W3040290377 cites W2020425332 @default.
• W3040290377 cites W2020960905 @default.
• W3040290377 cites W2023503151 @default.
• W3040290377 cites W2023805473 @default.
• W3040290377 cites W2023851810 @default.
• W3040290377 cites W2024429100 @default.
• W3040290377 cites W2024724616 @default.
• W3040290377 cites W2026082287 @default.
• W3040290377 cites W2027167684 @default.
• W3040290377 cites W2028612481 @default.
• W3040290377 cites W2032002871 @default.
• W3040290377 cites W2032073649 @default.
• W3040290377 cites W2032458313 @default.
• W3040290377 cites W2034005055 @default.
• W3040290377 cites W2034380866 @default.
• W3040290377 cites W2037842760 @default.
• W3040290377 cites W2041712989 @default.
• W3040290377 cites W2045375216 @default.
• W3040290377 cites W2048172410 @default.
• W3040290377 cites W2049562714 @default.
• W3040290377 cites W2050892140 @default.
• W3040290377 cites W2056574266 @default.
• W3040290377 cites W2057248497 @default.
• W3040290377 cites W2057609544 @default.
• W3040290377 cites W2059408854 @default.
• W3040290377 cites W2062060692 @default.
• W3040290377 cites W2062410076 @default.
• W3040290377 cites W2063029948 @default.
• W3040290377 cites W2064227724 @default.
• W3040290377 cites W2064431177 @default.
• W3040290377 cites W2065672011 @default.
• W3040290377 cites W2066919199 @default.
• W3040290377 cites W2076581254 @default.
• W3040290377 cites W2077548974 @default.
• W3040290377 cites W2078152971 @default.
• W3040290377 cites W2080325240 @default.
• W3040290377 cites W2081787890 @default.
• W3040290377 cites W2084141237 @default.
• W3040290377 cites W2087459059 @default.
• W3040290377 cites W2089149502 @default.
• W3040290377 cites W2089966875 @default.
• W3040290377 cites W2091096046 @default.
• W3040290377 cites W2094731629 @default.
• W3040290377 cites W2102668230 @default.
• W3040290377 cites W2104193042 @default.
• W3040290377 cites W2106069121 @default.
• W3040290377 cites W2106596828 @default.
• W3040290377 cites W2110363660 @default.
• W3040290377 cites W2114694296 @default.
• W3040290377 cites W2115133769 @default.
• W3040290377 cites W2116947619 @default.
• W3040290377 cites W2118935532 @default.
• W3040290377 cites W2120521869 @default.
• W3040290377 cites W2123098050 @default.
• W3040290377 cites W2124105006 @default.
• W3040290377 cites W2124275925 @default.
• W3040290377 cites W2124728669 @default.
• W3040290377 cites W2125471117 @default.
• W3040290377 cites W2126137648 @default.

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