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- W3040303463 abstract "Abstract Genes of unknown function are among the biggest challenges in molecular biology, especially in microbial systems, where 40%-60% of the predicted genes are unknown. Despite previous attempts, systematic approaches to include the unknown fraction into analytical workflows are still lacking. Here, we propose a conceptual framework and a computational workflow that bridge the known-unknown gap in genomes and metagenomes. We showcase our approach by exploring 415,971,742 genes predicted from 1,749 metagenomes and 28,941 bacterial and archaeal genomes. We quantify the extent of the unknown fraction, its diversity, and its relevance across multiple biomes. Furthermore, we provide a collection of 283,874 lineage-specific genes of unknown function for Cand . Patescibacteria, being a significant resource to expand our understanding of their unusual biology. Finally, by identifying a target gene of unknown function for antibiotic resistance, we demonstrate how we can enable the generation of hypotheses that can be used to augment experimental data." @default.
- W3040303463 created "2020-07-10" @default.
- W3040303463 creator A5003715080 @default.
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- W3040303463 creator A5091806083 @default.
- W3040303463 date "2020-07-01" @default.
- W3040303463 modified "2023-10-18" @default.
- W3040303463 title "Unifying the known and unknown microbial coding sequence space" @default.
- W3040303463 cites W1528357204 @default.
- W3040303463 cites W1884908671 @default.
- W3040303463 cites W1893309049 @default.
- W3040303463 cites W1936788844 @default.
- W3040303463 cites W1939911045 @default.
- W3040303463 cites W1956297315 @default.
- W3040303463 cites W1965186869 @default.
- W3040303463 cites W1969295076 @default.
- W3040303463 cites W1985468934 @default.
- W3040303463 cites W2008332643 @default.
- W3040303463 cites W2010775394 @default.
- W3040303463 cites W2020301105 @default.
- W3040303463 cites W2024708232 @default.
- W3040303463 cites W2040999012 @default.
- W3040303463 cites W2051210555 @default.
- W3040303463 cites W2056947791 @default.
- W3040303463 cites W2057197272 @default.
- W3040303463 cites W2059029000 @default.
- W3040303463 cites W2061525000 @default.
- W3040303463 cites W2065338712 @default.
- W3040303463 cites W2067658227 @default.
- W3040303463 cites W2077317706 @default.
- W3040303463 cites W2093233529 @default.
- W3040303463 cites W2096476896 @default.
- W3040303463 cites W2101220662 @default.
- W3040303463 cites W2102619694 @default.
- W3040303463 cites W2103385859 @default.
- W3040303463 cites W2109901328 @default.
- W3040303463 cites W2125230147 @default.
- W3040303463 cites W2125826054 @default.
- W3040303463 cites W2126142701 @default.
- W3040303463 cites W2127175247 @default.
- W3040303463 cites W2135621733 @default.
- W3040303463 cites W2138270253 @default.
- W3040303463 cites W2141052558 @default.
- W3040303463 cites W2143485490 @default.
- W3040303463 cites W2146906779 @default.
- W3040303463 cites W2147618390 @default.
- W3040303463 cites W2152177099 @default.
- W3040303463 cites W2152682668 @default.
- W3040303463 cites W2156125289 @default.
- W3040303463 cites W2156247618 @default.
- W3040303463 cites W2161091076 @default.
- W3040303463 cites W2166123725 @default.
- W3040303463 cites W2224056471 @default.
- W3040303463 cites W2254734290 @default.
- W3040303463 cites W2260037449 @default.
- W3040303463 cites W2279910557 @default.
- W3040303463 cites W2315521535 @default.
- W3040303463 cites W2437388877 @default.
- W3040303463 cites W2463304596 @default.
- W3040303463 cites W2515956436 @default.
- W3040303463 cites W2546522648 @default.
- W3040303463 cites W2580586713 @default.
- W3040303463 cites W2584305206 @default.
- W3040303463 cites W2735208100 @default.
- W3040303463 cites W2754579667 @default.
- W3040303463 cites W2756958651 @default.
- W3040303463 cites W2766104882 @default.
- W3040303463 cites W2767044445 @default.
- W3040303463 cites W2784434641 @default.
- W3040303463 cites W2789511815 @default.
- W3040303463 cites W2790894770 @default.
- W3040303463 cites W2792809884 @default.
- W3040303463 cites W2793041711 @default.
- W3040303463 cites W2804515387 @default.
- W3040303463 cites W2889019390 @default.
- W3040303463 cites W2895532240 @default.
- W3040303463 cites W2896674752 @default.
- W3040303463 cites W2897611961 @default.
- W3040303463 cites W2900629010 @default.
- W3040303463 cites W2910615673 @default.
- W3040303463 cites W2943203634 @default.
- W3040303463 cites W2944602870 @default.
- W3040303463 cites W2949342052 @default.
- W3040303463 cites W2949841808 @default.
- W3040303463 cites W2949968209 @default.
- W3040303463 cites W2950447040 @default.