FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3040307105> ?p ?o ?g. }

• W3040307105 abstract "Macroautophagy, the degradation of cytoplasmic content by lysosomal fusion, is an evolutionary conserved process promoting homeostasis and intracellular defence. Macroautophagy is initiated primarily by a complex containing ULK1 or ULK2 (two paralogs of the yeast Atg1 protein). To understand the differences between ULK1 and ULK2, we compared the human ULK1 and ULK2 proteins and their regulation. Despite the similarity in their enzymatic domain, we found that ULK1 and ULK2 have major differences in their autophagy-related interactors and their post-translational and transcriptional regulators. We identified 18 ULK1-specific and 7 ULK2-specific protein motifs serving as different interaction interfaces. We found that interactors of ULK1 and ULK2 all have different tissue-specific expressions partially contributing to diverse and ULK-specific interaction networks in various tissues. We identified three ULK1-specific and one ULK2-specific transcription factor binding sites, and eight sites shared by the regulatory region of both genes. Importantly, we found that both their post-translational and transcriptional regulators are involved in distinct biological processes-suggesting separate functions for ULK1 and ULK2. Unravelling differences between ULK1 and ULK2 could lead to a better understanding of how ULK-type specific dysregulation affects autophagy and other cellular processes that have been implicated in diseases such as inflammatory bowel disease and cancer." @default.
• W3040307105 created "2020-07-10" @default.
• W3040307105 creator A5009030612 @default.
• W3040307105 creator A5027550466 @default.
• W3040307105 creator A5027867456 @default.
• W3040307105 creator A5037926026 @default.
• W3040307105 creator A5073934272 @default.
• W3040307105 creator A5077136509 @default.
• W3040307105 date "2020-07-02" @default.
• W3040307105 modified "2023-10-14" @default.
• W3040307105 title "ULK1 and ULK2 are less redundant than previously thought: computational analysis uncovers distinct regulation and functions of these autophagy induction proteins" @default.
• W3040307105 cites W1512061023 @default.
• W3040307105 cites W1560977824 @default.
• W3040307105 cites W1774257523 @default.
• W3040307105 cites W1786980 @default.
• W3040307105 cites W1985124617 @default.
• W3040307105 cites W1987974497 @default.
• W3040307105 cites W1997056914 @default.
• W3040307105 cites W1998147787 @default.
• W3040307105 cites W1999388825 @default.
• W3040307105 cites W2011014580 @default.
• W3040307105 cites W2012034410 @default.
• W3040307105 cites W2012255493 @default.
• W3040307105 cites W2020489714 @default.
• W3040307105 cites W2025522492 @default.
• W3040307105 cites W2040656353 @default.
• W3040307105 cites W2041491503 @default.
• W3040307105 cites W2047405437 @default.
• W3040307105 cites W2048330355 @default.
• W3040307105 cites W2065582101 @default.
• W3040307105 cites W2066445581 @default.
• W3040307105 cites W2075165825 @default.
• W3040307105 cites W2087510837 @default.
• W3040307105 cites W2089728480 @default.
• W3040307105 cites W2092138236 @default.
• W3040307105 cites W2095485251 @default.
• W3040307105 cites W2102776209 @default.
• W3040307105 cites W2110036944 @default.
• W3040307105 cites W2118392656 @default.
• W3040307105 cites W2141781797 @default.
• W3040307105 cites W2145434871 @default.
• W3040307105 cites W2147293632 @default.
• W3040307105 cites W2154516787 @default.
• W3040307105 cites W2154768447 @default.
• W3040307105 cites W2156144699 @default.
• W3040307105 cites W2161803468 @default.
• W3040307105 cites W2166574880 @default.
• W3040307105 cites W2169816095 @default.
• W3040307105 cites W2188035077 @default.
• W3040307105 cites W2346316685 @default.
• W3040307105 cites W2471596662 @default.
• W3040307105 cites W2557833574 @default.
• W3040307105 cites W2587856226 @default.
• W3040307105 cites W2588413711 @default.
• W3040307105 cites W2766510537 @default.
• W3040307105 cites W2767841706 @default.
• W3040307105 cites W2770178180 @default.
• W3040307105 cites W2773814520 @default.
• W3040307105 cites W2782454362 @default.
• W3040307105 cites W2788534090 @default.
• W3040307105 cites W2788640168 @default.
• W3040307105 cites W2800245987 @default.
• W3040307105 cites W2808911710 @default.
• W3040307105 cites W2888777183 @default.
• W3040307105 cites W2898402099 @default.
• W3040307105 cites W2903005412 @default.
• W3040307105 cites W2937251669 @default.
• W3040307105 cites W2938574745 @default.
• W3040307105 cites W2953263404 @default.
• W3040307105 cites W2965495200 @default.
• W3040307105 cites W3015817113 @default.
• W3040307105 cites W4233120011 @default.
• W3040307105 doi "https://doi.org/10.1038/s41598-020-67780-2" @default.
• W3040307105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7331686" @default.
• W3040307105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32616830" @default.
• W3040307105 hasPublicationYear "2020" @default.
• W3040307105 type Work @default.
• W3040307105 sameAs 3040307105 @default.
• W3040307105 citedByCount "19" @default.
• W3040307105 countsByYear W30403071052021 @default.
• W3040307105 countsByYear W30403071052022 @default.
• W3040307105 countsByYear W30403071052023 @default.
• W3040307105 crossrefType "journal-article" @default.
• W3040307105 hasAuthorship W3040307105A5009030612 @default.
• W3040307105 hasAuthorship W3040307105A5027550466 @default.
• W3040307105 hasAuthorship W3040307105A5027867456 @default.
• W3040307105 hasAuthorship W3040307105A5037926026 @default.
• W3040307105 hasAuthorship W3040307105A5073934272 @default.
• W3040307105 hasAuthorship W3040307105A5077136509 @default.
• W3040307105 hasBestOaLocation W30403071051 @default.
• W3040307105 hasConcept C104317684 @default.
• W3040307105 hasConcept C123894998 @default.
• W3040307105 hasConcept C184235292 @default.
• W3040307105 hasConcept C190062978 @default.
• W3040307105 hasConcept C190283241 @default.
• W3040307105 hasConcept C203522944 @default.
• W3040307105 hasConcept C2780124434 @default.
• W3040307105 hasConcept C40767141 @default.
• W3040307105 hasConcept C54355233 @default.
• W3040307105 hasConcept C70721500 @default.

• next