Matches in SemOpenAlex for { <https://semopenalex.org/work/W3040339918> ?p ?o ?g. }
- W3040339918 endingPage "9230" @default.
- W3040339918 startingPage "9217" @default.
- W3040339918 abstract "Abstract Tumour‐associated macrophage (TAM) is an important component in tumour microenvironment. Generally, TAM exhibits the function of M2‐like macrophage, which was closely related to angiogenesis and tumour progression. Dioscin, a natural steroidal saponin, has shown its powerful anti‐tumour activity recently. However, the mechanism of dioscin involved in immune regulation is still obscure. Here, we observed dioscin induced macrophage M2‐to‐M1 phenotype transition in vitro and inhibited IL‐10 secretion. Meanwhile, the phagocytosis of macrophages was enhanced. In subcutaneous lung tumour models, dioscin inhibited the augmentation of M2 macrophage populations. Furthermore, dioscin down‐regulated STAT3 and JNK signalling pathways in macrophages in vitro. In BMDMs, activating JNK and inhibiting STAT3 induce macrophages to M1 polarization while inhibiting JNK and activating STAT3 to M2 polarization. Additionally, condition mediums from dioscin‐pre‐treated macrophages inhibited the migration of 3LL cells and the tube‐formation capacity of HUVECs. What's more, dioscin‐mediated macrophage polarization inhibited the in vivo metastasis of 3LL cells. In conclusion, dioscin may act as a new anti‐tumour agent by inhibiting TAMs via JNK and STAT3 pathways in lung cancer." @default.
- W3040339918 created "2020-07-10" @default.
- W3040339918 creator A5001172148 @default.
- W3040339918 creator A5010249534 @default.
- W3040339918 creator A5013786582 @default.
- W3040339918 creator A5017497699 @default.
- W3040339918 creator A5024128455 @default.
- W3040339918 creator A5046266040 @default.
- W3040339918 creator A5052132950 @default.
- W3040339918 creator A5062810742 @default.
- W3040339918 creator A5091500219 @default.
- W3040339918 date "2020-07-02" @default.
- W3040339918 modified "2023-10-15" @default.
- W3040339918 title "Dioscin elicits anti‐tumour immunity by inhibiting macrophage M2 polarization via JNK and STAT3 pathways in lung cancer" @default.
- W3040339918 cites W1518095394 @default.
- W3040339918 cites W1560380872 @default.
- W3040339918 cites W1654586227 @default.
- W3040339918 cites W1934538288 @default.
- W3040339918 cites W1960849084 @default.
- W3040339918 cites W1964375358 @default.
- W3040339918 cites W1969057487 @default.
- W3040339918 cites W1980485314 @default.
- W3040339918 cites W1987912219 @default.
- W3040339918 cites W2004630197 @default.
- W3040339918 cites W2011213725 @default.
- W3040339918 cites W2021277396 @default.
- W3040339918 cites W2030028321 @default.
- W3040339918 cites W2042207589 @default.
- W3040339918 cites W2043991982 @default.
- W3040339918 cites W2044227662 @default.
- W3040339918 cites W2058648826 @default.
- W3040339918 cites W2061123122 @default.
- W3040339918 cites W2070855360 @default.
- W3040339918 cites W2076011743 @default.
- W3040339918 cites W2099117852 @default.
- W3040339918 cites W2106027870 @default.
- W3040339918 cites W2107551122 @default.
- W3040339918 cites W2120053869 @default.
- W3040339918 cites W2121438383 @default.
- W3040339918 cites W2128856207 @default.
- W3040339918 cites W2142530756 @default.
- W3040339918 cites W2159560463 @default.
- W3040339918 cites W2162166699 @default.
- W3040339918 cites W2165200432 @default.
- W3040339918 cites W2190251723 @default.
- W3040339918 cites W2203686270 @default.
- W3040339918 cites W2262346292 @default.
- W3040339918 cites W2460290768 @default.
- W3040339918 cites W2464443297 @default.
- W3040339918 cites W2503580087 @default.
- W3040339918 cites W2569106599 @default.
- W3040339918 cites W2606694952 @default.
- W3040339918 cites W2614034516 @default.
- W3040339918 cites W2620916166 @default.
- W3040339918 cites W2729672742 @default.
- W3040339918 cites W2743136946 @default.
- W3040339918 cites W2744618200 @default.
- W3040339918 cites W2757117767 @default.
- W3040339918 cites W2757771081 @default.
- W3040339918 cites W2760582435 @default.
- W3040339918 cites W2791347732 @default.
- W3040339918 cites W2805252210 @default.
- W3040339918 cites W2896675733 @default.
- W3040339918 doi "https://doi.org/10.1111/jcmm.15563" @default.
- W3040339918 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7417694" @default.
- W3040339918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32618105" @default.
- W3040339918 hasPublicationYear "2020" @default.
- W3040339918 type Work @default.
- W3040339918 sameAs 3040339918 @default.
- W3040339918 citedByCount "33" @default.
- W3040339918 countsByYear W30403399182021 @default.
- W3040339918 countsByYear W30403399182022 @default.
- W3040339918 countsByYear W30403399182023 @default.
- W3040339918 crossrefType "journal-article" @default.
- W3040339918 hasAuthorship W3040339918A5001172148 @default.
- W3040339918 hasAuthorship W3040339918A5010249534 @default.
- W3040339918 hasAuthorship W3040339918A5013786582 @default.
- W3040339918 hasAuthorship W3040339918A5017497699 @default.
- W3040339918 hasAuthorship W3040339918A5024128455 @default.
- W3040339918 hasAuthorship W3040339918A5046266040 @default.
- W3040339918 hasAuthorship W3040339918A5052132950 @default.
- W3040339918 hasAuthorship W3040339918A5062810742 @default.
- W3040339918 hasAuthorship W3040339918A5091500219 @default.
- W3040339918 hasBestOaLocation W30403399181 @default.
- W3040339918 hasConcept C150903083 @default.
- W3040339918 hasConcept C160448771 @default.
- W3040339918 hasConcept C170493617 @default.
- W3040339918 hasConcept C185592680 @default.
- W3040339918 hasConcept C202751555 @default.
- W3040339918 hasConcept C203014093 @default.
- W3040339918 hasConcept C207001950 @default.
- W3040339918 hasConcept C2776682551 @default.
- W3040339918 hasConcept C2778923194 @default.
- W3040339918 hasConcept C2779244956 @default.
- W3040339918 hasConcept C2780394083 @default.
- W3040339918 hasConcept C2910375186 @default.
- W3040339918 hasConcept C49039625 @default.
- W3040339918 hasConcept C502942594 @default.