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- W3040357400 abstract "Abstract Objective Inhalation of noble and other gases after cardiac arrest (CA) might improve neurological and cardiac outcomes. This article discusses up-to-date information on this novel therapeutic intervention. Data sources CENTRAL, MEDLINE, online published abstracts from conference proceedings, clinical trial registry clinicaltrials.gov, and reference lists of relevant papers were systematically searched from January 1960 till March 2019. Study selection Preclinical and clinical studies, irrespective of their types or described outcomes, were included. Data extraction Abstract screening, study selection, and data extraction were performed by two independent authors. Due to the paucity of human trials, risk of bias assessment was not performed Data synthesis After screening 281 interventional studies, we included an overall of 27. Only, xenon, helium, hydrogen, and nitric oxide have been or are being studied on humans. Xenon, nitric oxide, and hydrogen show both neuroprotective and cardiotonic features, while argon and hydrogen sulfide seem neuroprotective, but not cardiotonic. Most gases have elicited neurohistological protection in preclinical studies; however, only hydrogen and hydrogen sulfide appeared to preserve CA1 sector of hippocampus, the most vulnerable area in the brain for hypoxia. Conclusion Inhalation of certain gases after CPR appears promising in mitigating neurological and cardiac damage and may become the next successful neuroprotective and cardiotonic interventions." @default.
- W3040357400 created "2020-07-10" @default.
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- W3040357400 date "2020-10-01" @default.
- W3040357400 modified "2023-09-27" @default.
- W3040357400 title "Administration of inhaled noble and other gases after cardiopulmonary resuscitation: A systematic review" @default.
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- W3040357400 doi "https://doi.org/10.1016/j.ajem.2020.06.066" @default.
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- W3040357400 hasPublicationYear "2020" @default.
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