FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3040374031> ?p ?o ?g. }

• W3040374031 endingPage "4960" @default.
• W3040374031 startingPage "4950" @default.
• W3040374031 abstract "Chemotherapy dosing duration and perfusion temperature vary significantly in HIPEC protocols. This study investigates patient-derived tumor organoids as a platform to identify the most efficacious perfusion protocol in a personalized approach.Peritoneal tumor tissue from 15 appendiceal and 8 colon cancer patients who underwent CRS/HIPEC were used for personalized organoid development. Organoids were perfused in parallel at 37 and 42 °C with low- and high-dose oxaliplatin (200 mg/m2 over 2 h vs. 460 mg/m2 over 30 min) and MMC (40 mg/3L over 2 h). Viability assays were performed and pooled for statistical analysis.An adequate organoid number was generated for 75% (6/8) of colon and 73% (11/15) of appendiceal patients. All 42 °C treatments displayed lower viability than 37 °C treatments. On pooled analysis, MMC and 200 mg/m2 oxaliplatin displayed no treatment difference for either appendiceal or colon organoids (19% vs. 25%, p = 0.22 and 27% vs. 31%, p = 0.55, respectively), whereas heated MMC was superior to 460 mg/m2 oxaliplatin in both primaries (19% vs. 54%, p < 0.001 and 27% vs. 53%, p = 0.002, respectively). In both appendiceal and colon tumor organoids, heated 200 mg/m2 oxaliplatin displayed increased cytotoxicity as compared with 460 mg/m2 oxaliplatin (25% vs. 54%, p < 0.001 and 31% vs. 53%, p = 0.008, respectively).Organoids treated with MMC or 200 mg/m2 heated oxaliplatin for 2 h displayed increased susceptibility in comparison with 30-min 460 mg/m2 oxaliplatin. Optimal perfusion protocol varies among patients, and organoid technology may offer a platform for tailoring HIPEC conditions to the individual patient level." @default.
• W3040374031 created "2020-07-10" @default.
• W3040374031 creator A5002210465 @default.
• W3040374031 creator A5019389023 @default.
• W3040374031 creator A5040292764 @default.
• W3040374031 creator A5045389785 @default.
• W3040374031 creator A5058662053 @default.
• W3040374031 creator A5064513536 @default.
• W3040374031 creator A5080464842 @default.
• W3040374031 creator A5082416075 @default.
• W3040374031 creator A5082665332 @default.
• W3040374031 date "2020-07-06" @default.
• W3040374031 modified "2023-10-10" @default.
• W3040374031 title "Personalized Identification of Optimal HIPEC Perfusion Protocol in Patient-Derived Tumor Organoid Platform" @default.
• W3040374031 cites W1563669981 @default.
• W3040374031 cites W1945602638 @default.
• W3040374031 cites W1968218040 @default.
• W3040374031 cites W1980784112 @default.
• W3040374031 cites W1994648960 @default.
• W3040374031 cites W2002513358 @default.
• W3040374031 cites W2002614487 @default.
• W3040374031 cites W2016868660 @default.
• W3040374031 cites W2031696462 @default.
• W3040374031 cites W2032007645 @default.
• W3040374031 cites W2071326357 @default.
• W3040374031 cites W2099306609 @default.
• W3040374031 cites W2165316896 @default.
• W3040374031 cites W2530979547 @default.
• W3040374031 cites W2754298229 @default.
• W3040374031 cites W2770466770 @default.
• W3040374031 cites W2771057425 @default.
• W3040374031 cites W2783728683 @default.
• W3040374031 cites W2788735115 @default.
• W3040374031 cites W2795679584 @default.
• W3040374031 cites W2801354110 @default.
• W3040374031 cites W2807088563 @default.
• W3040374031 cites W2809986038 @default.
• W3040374031 cites W2891846853 @default.
• W3040374031 cites W2899604688 @default.
• W3040374031 cites W2980113327 @default.
• W3040374031 cites W2987295172 @default.
• W3040374031 cites W2995499586 @default.
• W3040374031 doi "https://doi.org/10.1245/s10434-020-08790-2" @default.
• W3040374031 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7674215" @default.
• W3040374031 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32632882" @default.
• W3040374031 hasPublicationYear "2020" @default.
• W3040374031 type Work @default.
• W3040374031 sameAs 3040374031 @default.
• W3040374031 citedByCount "29" @default.
• W3040374031 countsByYear W30403740312020 @default.
• W3040374031 countsByYear W30403740312021 @default.
• W3040374031 countsByYear W30403740312022 @default.
• W3040374031 countsByYear W30403740312023 @default.
• W3040374031 crossrefType "journal-article" @default.
• W3040374031 hasAuthorship W3040374031A5002210465 @default.
• W3040374031 hasAuthorship W3040374031A5019389023 @default.
• W3040374031 hasAuthorship W3040374031A5040292764 @default.
• W3040374031 hasAuthorship W3040374031A5045389785 @default.
• W3040374031 hasAuthorship W3040374031A5058662053 @default.
• W3040374031 hasAuthorship W3040374031A5064513536 @default.
• W3040374031 hasAuthorship W3040374031A5080464842 @default.
• W3040374031 hasAuthorship W3040374031A5082416075 @default.
• W3040374031 hasAuthorship W3040374031A5082665332 @default.
• W3040374031 hasBestOaLocation W30403740312 @default.
• W3040374031 hasConcept C121608353 @default.
• W3040374031 hasConcept C126322002 @default.
• W3040374031 hasConcept C126894567 @default.
• W3040374031 hasConcept C146957229 @default.
• W3040374031 hasConcept C2776694085 @default.
• W3040374031 hasConcept C2780140570 @default.
• W3040374031 hasConcept C2780962732 @default.
• W3040374031 hasConcept C31695470 @default.
• W3040374031 hasConcept C526805850 @default.
• W3040374031 hasConcept C54355233 @default.
• W3040374031 hasConcept C71924100 @default.
• W3040374031 hasConcept C86803240 @default.
• W3040374031 hasConcept C90924648 @default.
• W3040374031 hasConceptScore W3040374031C121608353 @default.
• W3040374031 hasConceptScore W3040374031C126322002 @default.
• W3040374031 hasConceptScore W3040374031C126894567 @default.
• W3040374031 hasConceptScore W3040374031C146957229 @default.
• W3040374031 hasConceptScore W3040374031C2776694085 @default.
• W3040374031 hasConceptScore W3040374031C2780140570 @default.
• W3040374031 hasConceptScore W3040374031C2780962732 @default.
• W3040374031 hasConceptScore W3040374031C31695470 @default.
• W3040374031 hasConceptScore W3040374031C526805850 @default.
• W3040374031 hasConceptScore W3040374031C54355233 @default.
• W3040374031 hasConceptScore W3040374031C71924100 @default.
• W3040374031 hasConceptScore W3040374031C86803240 @default.
• W3040374031 hasConceptScore W3040374031C90924648 @default.
• W3040374031 hasIssue "13" @default.
• W3040374031 hasLocation W30403740311 @default.
• W3040374031 hasLocation W30403740312 @default.
• W3040374031 hasLocation W30403740313 @default.
• W3040374031 hasOpenAccess W3040374031 @default.
• W3040374031 hasPrimaryLocation W30403740311 @default.
• W3040374031 hasRelatedWork W2028339460 @default.
• W3040374031 hasRelatedWork W2207317950 @default.

• next