FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3040374725> ?p ?o ?g. }

• W3040374725 endingPage "A56" @default.
• W3040374725 startingPage "A56" @default.
• W3040374725 abstract "Abstract Glycosylated antitumor ether lipids (GAELs) are a promising class of investigational anticancer agents with potent antitumor activity against a range of cancers, including platinum-resistant high-grade serous ovarian cancer (HGSOC). We previously demonstrated that epithelial ovarian cancer (EOC) cell lines (HGSOC and endometrioid) and primary cells derived from patient ascites (HGSOC and clear cell) were sensitive to the cell-killing effects of D-glucosamine-derived GAELs via an apoptosis-independent mechanism. However, D-linked carbohydrates are metabolized by endogenous glucosidases in vivo, rendering the GAEL inactive. Thus, the aim of the current study was to synthesize a novel class of GAELs with L-linked carbohydrates and to evaluate their efficacy in EOC cell lines and patient samples. Out of seven novel compounds tested, L-rhamnose-GAEL was identified as the compound with the greatest efficacy for killing EOC cell lines and patient cells that were grown under adherent or nonadherent (3D) conditions. The drug-sensitive and drug-resistant syngeneic endometrioid EOC cell lines, A2780s and A2780cp, respectively, as well as the NIH:OVCAR-3 and COV362 HGSOC lines, were incubated with L-rhamnose-GAEL for 48 hours and the CC50 determined as 15 μM for A2780s, 22.5 μM for A2780cp, and 5 μM for NIH:OVCAR-3 and COV362 cells. Similar experiments were conducted with primary EOC cells, chemo-naïve EOC126 (clear-cell adenocarcinoma), and platinum-resistant EOC 183I (HGSOC). Cell viability decreased in a dose-dependent manner with CC50 of 12 μM for EOC126 and 22.5 μM for EOC183l. For comparison, when EOC126 and EOC183I were grown as 3D cultures the CC50for cisplatin was 20 μM and 40 μM, respectively. To evaluate the effect of using low-dose treatment of L-rhamnose-GAEL on primary EOC cells (chemo-naive and chemoresistant), cells were exposed to L-rhamnose-GAEL for 96 hours. These studies revealed that prolonged incubation led to low CC50 of 1-5 μM. These results showed that primary EOC cells derived from chemo-naïve and platinum-resistant patients were sensitive to the L-rhamnose-GAEL and offer a novel drug class capable of killing chemotherapy-resistant EOC cells. Citation Format: Mark W. Nachtigal, Frank Schweizer, Gilbert Arthur. Novel L-sugar linked glycosylated antitumor ether lipids for killing platinum-resistant human epithelial ovarian cancer cells [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research; 2019 Sep 13-16, 2019; Atlanta, GA. Philadelphia (PA): AACR; Clin Cancer Res 2020;26(13_Suppl):Abstract nr A56." @default.
• W3040374725 created "2020-07-10" @default.
• W3040374725 creator A5036742324 @default.
• W3040374725 creator A5048485968 @default.
• W3040374725 creator A5063258446 @default.
• W3040374725 date "2020-07-01" @default.
• W3040374725 modified "2023-09-27" @default.
• W3040374725 title "Abstract A56: Novel L-sugar linked glycosylated antitumor ether lipids for killing platinum-resistant human epithelial ovarian cancer cells" @default.
• W3040374725 doi "https://doi.org/10.1158/1557-3265.ovca19-a56" @default.
• W3040374725 hasPublicationYear "2020" @default.
• W3040374725 type Work @default.
• W3040374725 sameAs 3040374725 @default.
• W3040374725 citedByCount "0" @default.
• W3040374725 crossrefType "journal-article" @default.
• W3040374725 hasAuthorship W3040374725A5036742324 @default.
• W3040374725 hasAuthorship W3040374725A5048485968 @default.
• W3040374725 hasAuthorship W3040374725A5063258446 @default.
• W3040374725 hasConcept C121608353 @default.
• W3040374725 hasConcept C126322002 @default.
• W3040374725 hasConcept C1491633281 @default.
• W3040374725 hasConcept C150173356 @default.
• W3040374725 hasConcept C150903083 @default.
• W3040374725 hasConcept C185592680 @default.
• W3040374725 hasConcept C190283241 @default.
• W3040374725 hasConcept C207001950 @default.
• W3040374725 hasConcept C2780427987 @default.
• W3040374725 hasConcept C502942594 @default.
• W3040374725 hasConcept C54355233 @default.
• W3040374725 hasConcept C55493867 @default.
• W3040374725 hasConcept C71924100 @default.
• W3040374725 hasConcept C81885089 @default.
• W3040374725 hasConcept C86803240 @default.
• W3040374725 hasConcept C96232424 @default.
• W3040374725 hasConceptScore W3040374725C121608353 @default.
• W3040374725 hasConceptScore W3040374725C126322002 @default.
• W3040374725 hasConceptScore W3040374725C1491633281 @default.
• W3040374725 hasConceptScore W3040374725C150173356 @default.
• W3040374725 hasConceptScore W3040374725C150903083 @default.
• W3040374725 hasConceptScore W3040374725C185592680 @default.
• W3040374725 hasConceptScore W3040374725C190283241 @default.
• W3040374725 hasConceptScore W3040374725C207001950 @default.
• W3040374725 hasConceptScore W3040374725C2780427987 @default.
• W3040374725 hasConceptScore W3040374725C502942594 @default.
• W3040374725 hasConceptScore W3040374725C54355233 @default.
• W3040374725 hasConceptScore W3040374725C55493867 @default.
• W3040374725 hasConceptScore W3040374725C71924100 @default.
• W3040374725 hasConceptScore W3040374725C81885089 @default.
• W3040374725 hasConceptScore W3040374725C86803240 @default.
• W3040374725 hasConceptScore W3040374725C96232424 @default.
• W3040374725 hasIssue "13_Supplement" @default.
• W3040374725 hasLocation W30403747251 @default.
• W3040374725 hasOpenAccess W3040374725 @default.
• W3040374725 hasPrimaryLocation W30403747251 @default.
• W3040374725 hasRelatedWork W1518035471 @default.
• W3040374725 hasRelatedWork W1975372488 @default.
• W3040374725 hasRelatedWork W1981600545 @default.
• W3040374725 hasRelatedWork W2030883789 @default.
• W3040374725 hasRelatedWork W2069300823 @default.
• W3040374725 hasRelatedWork W2370888976 @default.
• W3040374725 hasRelatedWork W2378785636 @default.
• W3040374725 hasRelatedWork W2386605958 @default.
• W3040374725 hasRelatedWork W2501960686 @default.
• W3040374725 hasRelatedWork W3012168770 @default.
• W3040374725 hasVolume "26" @default.
• W3040374725 isParatext "false" @default.
• W3040374725 isRetracted "false" @default.
• W3040374725 magId "3040374725" @default.
• W3040374725 workType "article" @default.