FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3040421695> ?p ?o ?g. }

• W3040421695 abstract "Uncoupling protein 1 (UCP1) governs non-shivering thermogenesis in brown adipose tissue. It has been estimated that pigs lost UCP1 ∼20 million years ago (MYA), dictating cold intolerance among piglets. Our current understanding of the root causes of UCP1 loss are, however, incomplete. Thus, examination of additional species can shed light on these fundamental evolutionary questions. Here, we investigated Chacoan peccary (Catagonus wagneri) UCP1, a member of the Tayassuid lineage that diverged from pigs during the Late Eocene-Mid Oligocene. Peccary UCP1 exons 1 and 2 have been deleted while the remaining exons display additional inactivating mutations. A common nonsense mutation in exon 6 reveals UCP1 was pseudogenized in a shared ancestor of pigs and peccaries. Our selection pressure analyses indicate the inactivation occurred much earlier, 36.2-44.3 MYA during the mid-late Eocene, than previously thought. Importantly, pseudogenized UCP1 provides the molecular basis for cold sensitivity and current tropical biogeography of extant peccaries." @default.
• W3040421695 created "2020-07-10" @default.
• W3040421695 creator A5000999414 @default.
• W3040421695 creator A5052766513 @default.
• W3040421695 creator A5085526063 @default.
• W3040421695 creator A5088670288 @default.
• W3040421695 date "2020-01-01" @default.
• W3040421695 modified "2023-09-30" @default.
• W3040421695 title "Disruption of thermogenic <i>UCP1</i> predated the divergence of pigs and peccaries" @default.
• W3040421695 cites W1880608758 @default.
• W3040421695 cites W1900866157 @default.
• W3040421695 cites W1970714913 @default.
• W3040421695 cites W2020422478 @default.
• W3040421695 cites W2020697299 @default.
• W3040421695 cites W2027993356 @default.
• W3040421695 cites W2028082494 @default.
• W3040421695 cites W2035744825 @default.
• W3040421695 cites W2045759308 @default.
• W3040421695 cites W2058085290 @default.
• W3040421695 cites W2063404756 @default.
• W3040421695 cites W2068828991 @default.
• W3040421695 cites W2089427897 @default.
• W3040421695 cites W2091553799 @default.
• W3040421695 cites W2110335151 @default.
• W3040421695 cites W2119475585 @default.
• W3040421695 cites W2127495923 @default.
• W3040421695 cites W2132643262 @default.
• W3040421695 cites W2140803428 @default.
• W3040421695 cites W2146712280 @default.
• W3040421695 cites W2155310221 @default.
• W3040421695 cites W2159228174 @default.
• W3040421695 cites W2520224170 @default.
• W3040421695 cites W2571390559 @default.
• W3040421695 cites W2606835133 @default.
• W3040421695 cites W2613011871 @default.
• W3040421695 cites W2755763414 @default.
• W3040421695 cites W2793768356 @default.
• W3040421695 cites W2808388187 @default.
• W3040421695 cites W2906565140 @default.
• W3040421695 cites W2949907612 @default.
• W3040421695 cites W2952048439 @default.
• W3040421695 doi "https://doi.org/10.1242/jeb.223974" @default.
• W3040421695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34005653" @default.
• W3040421695 hasPublicationYear "2020" @default.
• W3040421695 type Work @default.
• W3040421695 sameAs 3040421695 @default.
• W3040421695 citedByCount "8" @default.
• W3040421695 countsByYear W30404216952021 @default.
• W3040421695 countsByYear W30404216952022 @default.
• W3040421695 countsByYear W30404216952023 @default.
• W3040421695 crossrefType "journal-article" @default.
• W3040421695 hasAuthorship W3040421695A5000999414 @default.
• W3040421695 hasAuthorship W3040421695A5052766513 @default.
• W3040421695 hasAuthorship W3040421695A5085526063 @default.
• W3040421695 hasAuthorship W3040421695A5088670288 @default.
• W3040421695 hasBestOaLocation W30404216951 @default.
• W3040421695 hasConcept C104317684 @default.
• W3040421695 hasConcept C151279926 @default.
• W3040421695 hasConcept C171089720 @default.
• W3040421695 hasConcept C2776817793 @default.
• W3040421695 hasConcept C2780642333 @default.
• W3040421695 hasConcept C36823959 @default.
• W3040421695 hasConcept C54355233 @default.
• W3040421695 hasConcept C55493867 @default.
• W3040421695 hasConcept C7602840 @default.
• W3040421695 hasConcept C78458016 @default.
• W3040421695 hasConcept C81979416 @default.
• W3040421695 hasConcept C86803240 @default.
• W3040421695 hasConcept C90856448 @default.
• W3040421695 hasConceptScore W3040421695C104317684 @default.
• W3040421695 hasConceptScore W3040421695C151279926 @default.
• W3040421695 hasConceptScore W3040421695C171089720 @default.
• W3040421695 hasConceptScore W3040421695C2776817793 @default.
• W3040421695 hasConceptScore W3040421695C2780642333 @default.
• W3040421695 hasConceptScore W3040421695C36823959 @default.
• W3040421695 hasConceptScore W3040421695C54355233 @default.
• W3040421695 hasConceptScore W3040421695C55493867 @default.
• W3040421695 hasConceptScore W3040421695C7602840 @default.
• W3040421695 hasConceptScore W3040421695C78458016 @default.
• W3040421695 hasConceptScore W3040421695C81979416 @default.
• W3040421695 hasConceptScore W3040421695C86803240 @default.
• W3040421695 hasConceptScore W3040421695C90856448 @default.
• W3040421695 hasFunder F4320322581 @default.
• W3040421695 hasLocation W30404216951 @default.
• W3040421695 hasLocation W30404216952 @default.
• W3040421695 hasOpenAccess W3040421695 @default.
• W3040421695 hasPrimaryLocation W30404216951 @default.
• W3040421695 hasRelatedWork W1982275498 @default.
• W3040421695 hasRelatedWork W2080098347 @default.
• W3040421695 hasRelatedWork W2099479611 @default.
• W3040421695 hasRelatedWork W2148601167 @default.
• W3040421695 hasRelatedWork W2510840747 @default.
• W3040421695 hasRelatedWork W2519472217 @default.
• W3040421695 hasRelatedWork W2980740621 @default.
• W3040421695 hasRelatedWork W3029715290 @default.
• W3040421695 hasRelatedWork W3047633609 @default.
• W3040421695 hasRelatedWork W3138566262 @default.
• W3040421695 isParatext "false" @default.
• W3040421695 isRetracted "false" @default.
• W3040421695 magId "3040421695" @default.

• next