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• W3040459322 abstract "Proliferation and migration of vascular smooth muscle cells (VSMCs) are implicated in blood vessel development, maintenance of vascular homeostasis, and pathogenesis of vascular disorders. MicroRNAs (miRNAs) mediate the regulation of VSMC functions in response to microenvironmental signals. Because a previous study reported that miR-101, a tumor-suppressive miRNA, is a critical regulator of cell proliferation in vascular disease, we hypothesized that miR-101 controls important cellular processes in VSMCs. The present study aimed to elucidate the effects of miR-101 on VSMC function and its molecular mechanisms. We revealed that miR-101 regulates VSMC proliferation and migration. We showed that miR-101 expression is induced by bone morphogenetic protein (BMP) signaling, and we identified dedicator of cytokinesis 4 (DOCK4) as a novel target of miR-101. Our results suggest that the BMP–miR-101–DOCK4 axis mediates the regulation of VSMC function. Our findings help further the understanding of vascular physiology and pathology." @default.
• W3040459322 created "2020-07-10" @default.
• W3040459322 creator A5028796996 @default.
• W3040459322 creator A5056331231 @default.
• W3040459322 date "2020-07-04" @default.
• W3040459322 modified "2023-10-14" @default.
• W3040459322 title "BMP-Induced MicroRNA-101 Expression Regulates Vascular Smooth Muscle Cell Migration" @default.
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• W3040459322 doi "https://doi.org/10.3390/ijms21134764" @default.
• W3040459322 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7369869" @default.
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