FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3040467129> ?p ?o ?g. }

• W3040467129 endingPage "115127" @default.
• W3040467129 startingPage "115127" @default.
• W3040467129 abstract "Pregnant women are one of the most susceptible and vulnerable groups to malaria, the most important parasitic disease worldwide. Artemisinin-based combination therapies (ACTs) are recommended for the treatment of uncomplicated malaria in all population groups including pregnant women. However, due to the embryotoxicity observed in animal studies, ACTs have long been contraindicated during the first trimester in pregnant women. Despite the safety concerns raised in pre-clinical studies, recent findings on ACTs's use in pregnant women appear to be reassuring regarding safety and have prompted a revision of malaria treatment guidelines for first trimester of pregnancy. To contribute to the risk-benefit assessment of ACTs, we conducted a systematic literature review of animal studies published between 2007 and 2019, which evaluated the embryotoxic effects of artemisinin and its derivatives among pregnant mammals. Eighteen experimental studies fitted the inclusion criteria. These studies confirmed and further characterized the severe embryolethal and embryotoxic dose-dependent effects of artemisinin and its derivatives when administered during the organogenesis period in rats, rabbits and monkeys. Timing of administration and dosage of the drug were found to be key factors in the appearance of embryo damage. Overall, the translation of the findings of artemisinin derivatives use in animal studies to pregnant women remains disturbing. Thus, a policy change in the use of ACTs during the first trimester in pregnant women for the treatment of uncomplicated malaria does not seem pertinent and if implemented, it should be accompanied by solid pharmacovigilance systems, which are challenging to establish in malaria endemic countries." @default.
• W3040467129 created "2020-07-10" @default.
• W3040467129 creator A5006113825 @default.
• W3040467129 creator A5007933627 @default.
• W3040467129 creator A5015285519 @default.
• W3040467129 creator A5022330980 @default.
• W3040467129 creator A5040079271 @default.
• W3040467129 creator A5048668433 @default.
• W3040467129 date "2020-09-01" @default.
• W3040467129 modified "2023-10-17" @default.
• W3040467129 title "Systematic review of artemisinin embryotoxicity in animals: Implications for malaria control in human pregnancy" @default.
• W3040467129 cites W1600572148 @default.
• W3040467129 cites W1978216857 @default.
• W3040467129 cites W1983286872 @default.
• W3040467129 cites W1987111910 @default.
• W3040467129 cites W1987115509 @default.
• W3040467129 cites W1992976934 @default.
• W3040467129 cites W1996882284 @default.
• W3040467129 cites W2013022548 @default.
• W3040467129 cites W2014387796 @default.
• W3040467129 cites W2021213249 @default.
• W3040467129 cites W2023405265 @default.
• W3040467129 cites W2023515076 @default.
• W3040467129 cites W2023941860 @default.
• W3040467129 cites W2031430283 @default.
• W3040467129 cites W2040694163 @default.
• W3040467129 cites W2040780490 @default.
• W3040467129 cites W2045916442 @default.
• W3040467129 cites W2060897594 @default.
• W3040467129 cites W2064773896 @default.
• W3040467129 cites W2067593593 @default.
• W3040467129 cites W2067629859 @default.
• W3040467129 cites W2071906583 @default.
• W3040467129 cites W2073985069 @default.
• W3040467129 cites W2086676526 @default.
• W3040467129 cites W2096581579 @default.
• W3040467129 cites W2099534544 @default.
• W3040467129 cites W2101953549 @default.
• W3040467129 cites W2109650275 @default.
• W3040467129 cites W2119701561 @default.
• W3040467129 cites W2128779446 @default.
• W3040467129 cites W2129816308 @default.
• W3040467129 cites W2135689286 @default.
• W3040467129 cites W2137827130 @default.
• W3040467129 cites W2149185499 @default.
• W3040467129 cites W2151019491 @default.
• W3040467129 cites W2152793164 @default.
• W3040467129 cites W2156949967 @default.
• W3040467129 cites W2162842262 @default.
• W3040467129 cites W2163187040 @default.
• W3040467129 cites W2168177094 @default.
• W3040467129 cites W2168652259 @default.
• W3040467129 cites W2181657564 @default.
• W3040467129 cites W2261876003 @default.
• W3040467129 cites W2412919500 @default.
• W3040467129 cites W2567485077 @default.
• W3040467129 cites W2573149890 @default.
• W3040467129 cites W2610284326 @default.
• W3040467129 cites W2715519994 @default.
• W3040467129 cites W2771050118 @default.
• W3040467129 cites W2772777925 @default.
• W3040467129 cites W4294215472 @default.
• W3040467129 doi "https://doi.org/10.1016/j.taap.2020.115127" @default.
• W3040467129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32622917" @default.
• W3040467129 hasPublicationYear "2020" @default.
• W3040467129 type Work @default.
• W3040467129 sameAs 3040467129 @default.
• W3040467129 citedByCount "9" @default.
• W3040467129 countsByYear W30404671292020 @default.
• W3040467129 countsByYear W30404671292022 @default.
• W3040467129 countsByYear W30404671292023 @default.
• W3040467129 crossrefType "journal-article" @default.
• W3040467129 hasAuthorship W3040467129A5006113825 @default.
• W3040467129 hasAuthorship W3040467129A5007933627 @default.
• W3040467129 hasAuthorship W3040467129A5015285519 @default.
• W3040467129 hasAuthorship W3040467129A5022330980 @default.
• W3040467129 hasAuthorship W3040467129A5040079271 @default.
• W3040467129 hasAuthorship W3040467129A5048668433 @default.
• W3040467129 hasConcept C177713679 @default.
• W3040467129 hasConcept C203014093 @default.
• W3040467129 hasConcept C2776120307 @default.
• W3040467129 hasConcept C2778048844 @default.
• W3040467129 hasConcept C2778371730 @default.
• W3040467129 hasConcept C2779234561 @default.
• W3040467129 hasConcept C2780035454 @default.
• W3040467129 hasConcept C2908647359 @default.
• W3040467129 hasConcept C54355233 @default.
• W3040467129 hasConcept C57658597 @default.
• W3040467129 hasConcept C71924100 @default.
• W3040467129 hasConcept C86803240 @default.
• W3040467129 hasConcept C98274493 @default.
• W3040467129 hasConcept C99454951 @default.
• W3040467129 hasConceptScore W3040467129C177713679 @default.
• W3040467129 hasConceptScore W3040467129C203014093 @default.
• W3040467129 hasConceptScore W3040467129C2776120307 @default.
• W3040467129 hasConceptScore W3040467129C2778048844 @default.
• W3040467129 hasConceptScore W3040467129C2778371730 @default.
• W3040467129 hasConceptScore W3040467129C2779234561 @default.

• next