FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3040501129> ?p ?o ?g. }

• W3040501129 endingPage "104361" @default.
• W3040501129 startingPage "104361" @default.
• W3040501129 abstract "The innate immune system is the first line of defense in vertebrates against microbial pathogens. This defense system depends on the peptidoglycan pathogen recognition of receptors (PGRPs) existing in both invertebrates and vertebrates. Although some studies revealed the structural and functional differences between them, however, the evolutionary history and the selection pressures on these genes during adaptive evolution are poorly understood. In this study, we examined four (PGLYRP1, PGLYRP2, PGLYRP3, and PGLYRP4) genes of 127 vertebrates’ species, conserved across vertebrates to evaluate positive selection pressure drives by adaptive evolution. The codons under positive selection were recognized through likelihood tests by comparing different models based on ω ratios in these genes across the vertebrate species. The positive selection test used two sets of models M1a vs. M2a and M7 vs. M8. The results showed that the test of these genes in M1a vs. M2a was not significant with the likelihood value 2ΔlnL = 0, while the likelihood ratios (2ΔlnL) were 2ΔlnL = 12.386, 2ΔlnL = 4.9283, 2ΔlnL = 24.031, and 2ΔlnL = 103.39 for PGLYRP1, PGLYRP2, PGLYRP3, and PGLYRP4 in M7 vs. M8, respectively. Our study identified the evidence of robust positive selection for these four genes across the vertebrates. These protuberant changes in PGRPs evolution of vertebrates reveal their role in innate immunity. Our study provides an insight based on PGRP genes to understand the evolution of host and pathogens interaction that leads to the progress of the novel conducts for immune diseases that include proteins linked to the recognition of pathogens." @default.
• W3040501129 created "2020-07-10" @default.
• W3040501129 creator A5009324619 @default.
• W3040501129 creator A5025131884 @default.
• W3040501129 creator A5025587948 @default.
• W3040501129 creator A5028056610 @default.
• W3040501129 creator A5029078513 @default.
• W3040501129 creator A5032675428 @default.
• W3040501129 creator A5033621377 @default.
• W3040501129 creator A5035051680 @default.
• W3040501129 creator A5045728501 @default.
• W3040501129 creator A5057774464 @default.
• W3040501129 creator A5065824677 @default.
• W3040501129 creator A5076552073 @default.
• W3040501129 creator A5084567999 @default.
• W3040501129 date "2020-10-01" @default.
• W3040501129 modified "2023-10-13" @default.
• W3040501129 title "Adaptive evolution of peptidoglycan recognition protein family regulates the innate signaling against microbial pathogens in vertebrates" @default.
• W3040501129 cites W1964475452 @default.
• W3040501129 cites W1973101413 @default.
• W3040501129 cites W1978074720 @default.
• W3040501129 cites W1987134040 @default.
• W3040501129 cites W1988719235 @default.
• W3040501129 cites W1992192767 @default.
• W3040501129 cites W2016779764 @default.
• W3040501129 cites W2024974737 @default.
• W3040501129 cites W2029549914 @default.
• W3040501129 cites W2046214216 @default.
• W3040501129 cites W2060259273 @default.
• W3040501129 cites W2063476718 @default.
• W3040501129 cites W2081895836 @default.
• W3040501129 cites W2082928585 @default.
• W3040501129 cites W2089299751 @default.
• W3040501129 cites W2089719819 @default.
• W3040501129 cites W2096230176 @default.
• W3040501129 cites W2108512869 @default.
• W3040501129 cites W2110335151 @default.
• W3040501129 cites W2116211618 @default.
• W3040501129 cites W2122029391 @default.
• W3040501129 cites W2126234813 @default.
• W3040501129 cites W2126371317 @default.
• W3040501129 cites W2132629607 @default.
• W3040501129 cites W2133585817 @default.
• W3040501129 cites W2136847298 @default.
• W3040501129 cites W2138178197 @default.
• W3040501129 cites W2140028978 @default.
• W3040501129 cites W2146341019 @default.
• W3040501129 cites W2148814198 @default.
• W3040501129 cites W2150444353 @default.
• W3040501129 cites W2150700711 @default.
• W3040501129 cites W2152207030 @default.
• W3040501129 cites W2155330008 @default.
• W3040501129 cites W2159620937 @default.
• W3040501129 cites W2164385416 @default.
• W3040501129 cites W2164683872 @default.
• W3040501129 cites W2166444569 @default.
• W3040501129 cites W2168621448 @default.
• W3040501129 cites W2304458632 @default.
• W3040501129 cites W2413270549 @default.
• W3040501129 cites W2523801326 @default.
• W3040501129 cites W2589288765 @default.
• W3040501129 cites W2604308930 @default.
• W3040501129 cites W2624210122 @default.
• W3040501129 cites W2746575864 @default.
• W3040501129 cites W2756776322 @default.
• W3040501129 cites W2758232878 @default.
• W3040501129 cites W2768503917 @default.
• W3040501129 cites W2782073709 @default.
• W3040501129 cites W2783422106 @default.
• W3040501129 cites W2809524618 @default.
• W3040501129 cites W2896709989 @default.
• W3040501129 cites W2906155646 @default.
• W3040501129 cites W2921541289 @default.
• W3040501129 cites W2937984258 @default.
• W3040501129 cites W2938810448 @default.
• W3040501129 cites W2950581144 @default.
• W3040501129 cites W2951796795 @default.
• W3040501129 cites W2964641029 @default.
• W3040501129 cites W3006615430 @default.
• W3040501129 cites W4210347168 @default.
• W3040501129 cites W4236710418 @default.
• W3040501129 cites W4294216483 @default.
• W3040501129 doi "https://doi.org/10.1016/j.micpath.2020.104361" @default.
• W3040501129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32622926" @default.
• W3040501129 hasPublicationYear "2020" @default.
• W3040501129 type Work @default.
• W3040501129 sameAs 3040501129 @default.
• W3040501129 citedByCount "13" @default.
• W3040501129 countsByYear W30405011292021 @default.
• W3040501129 countsByYear W30405011292022 @default.
• W3040501129 countsByYear W30405011292023 @default.
• W3040501129 crossrefType "journal-article" @default.
• W3040501129 hasAuthorship W3040501129A5009324619 @default.
• W3040501129 hasAuthorship W3040501129A5025131884 @default.
• W3040501129 hasAuthorship W3040501129A5025587948 @default.
• W3040501129 hasAuthorship W3040501129A5028056610 @default.
• W3040501129 hasAuthorship W3040501129A5029078513 @default.
• W3040501129 hasAuthorship W3040501129A5032675428 @default.

• next