Matches in SemOpenAlex for { <https://semopenalex.org/work/W3040557065> ?p ?o ?g. }
- W3040557065 endingPage "1570" @default.
- W3040557065 startingPage "1562" @default.
- W3040557065 abstract "Abstract Loss of β‐cell mass and function can lead to insufficient insulin levels and ultimately to hyperglycemia and diabetes mellitus. The mainstream treatment approach involves regulation of insulin levels; however, approaches intended to increase β‐cell mass are less developed. Promoting β‐cell proliferation with low‐molecular‐weight inhibitors of dual‐specificity tyrosine‐regulated kinase 1A (DYRK1A) offers the potential to treat diabetes with oral therapies by restoring β‐cell mass, insulin content and glycemic control. GNF4877, a potent dual inhibitor of DYRK1A and glycogen synthase kinase 3β (GSK3β) was previously reported to induce primary human β‐cell proliferation in vitro and in vivo . Herein, we describe the lead optimization that lead to the identification of GNF4877 from an aminopyrazine hit identified in a phenotypic high‐throughput screening campaign measuring β‐cell proliferation." @default.
- W3040557065 created "2020-07-10" @default.
- W3040557065 creator A5003199141 @default.
- W3040557065 creator A5004590479 @default.
- W3040557065 creator A5012677271 @default.
- W3040557065 creator A5021133499 @default.
- W3040557065 creator A5026465169 @default.
- W3040557065 creator A5029728251 @default.
- W3040557065 creator A5034167556 @default.
- W3040557065 creator A5034711601 @default.
- W3040557065 creator A5037351209 @default.
- W3040557065 creator A5038069675 @default.
- W3040557065 creator A5041585576 @default.
- W3040557065 creator A5041856800 @default.
- W3040557065 creator A5043102433 @default.
- W3040557065 creator A5043840854 @default.
- W3040557065 creator A5044837743 @default.
- W3040557065 creator A5048810295 @default.
- W3040557065 creator A5056470075 @default.
- W3040557065 creator A5056538621 @default.
- W3040557065 creator A5056748585 @default.
- W3040557065 creator A5057602002 @default.
- W3040557065 creator A5060888055 @default.
- W3040557065 creator A5062815482 @default.
- W3040557065 creator A5063258226 @default.
- W3040557065 creator A5064640228 @default.
- W3040557065 creator A5065193344 @default.
- W3040557065 creator A5075503065 @default.
- W3040557065 creator A5078127304 @default.
- W3040557065 creator A5078381393 @default.
- W3040557065 creator A5083463805 @default.
- W3040557065 date "2020-07-02" @default.
- W3040557065 modified "2023-10-16" @default.
- W3040557065 title "A Dual Inhibitor of DYRK1A and GSK3β for β‐Cell Proliferation: Aminopyrazine Derivative GNF4877" @default.
- W3040557065 cites W1966835818 @default.
- W3040557065 cites W1985508368 @default.
- W3040557065 cites W1995346182 @default.
- W3040557065 cites W2003454094 @default.
- W3040557065 cites W2011588737 @default.
- W3040557065 cites W2017895219 @default.
- W3040557065 cites W2040716278 @default.
- W3040557065 cites W2051603499 @default.
- W3040557065 cites W2054228896 @default.
- W3040557065 cites W2070186790 @default.
- W3040557065 cites W2149109263 @default.
- W3040557065 cites W2157521111 @default.
- W3040557065 cites W2160723017 @default.
- W3040557065 cites W2164119566 @default.
- W3040557065 cites W2168175722 @default.
- W3040557065 cites W2211873065 @default.
- W3040557065 cites W2221658929 @default.
- W3040557065 cites W2258420810 @default.
- W3040557065 cites W2317002250 @default.
- W3040557065 cites W2322477027 @default.
- W3040557065 cites W2333335236 @default.
- W3040557065 cites W2338172248 @default.
- W3040557065 cites W2339355315 @default.
- W3040557065 cites W2519466520 @default.
- W3040557065 cites W2591903626 @default.
- W3040557065 cites W2733324404 @default.
- W3040557065 cites W2740631829 @default.
- W3040557065 cites W2790048311 @default.
- W3040557065 cites W2796873125 @default.
- W3040557065 cites W2830873838 @default.
- W3040557065 cites W2886244301 @default.
- W3040557065 cites W2888225327 @default.
- W3040557065 cites W2906475498 @default.
- W3040557065 cites W2915504924 @default.
- W3040557065 cites W2987752990 @default.
- W3040557065 cites W3004297425 @default.
- W3040557065 cites W3005696213 @default.
- W3040557065 cites W3008625044 @default.
- W3040557065 doi "https://doi.org/10.1002/cmdc.202000183" @default.
- W3040557065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32613743" @default.
- W3040557065 hasPublicationYear "2020" @default.
- W3040557065 type Work @default.
- W3040557065 sameAs 3040557065 @default.
- W3040557065 citedByCount "7" @default.
- W3040557065 countsByYear W30405570652021 @default.
- W3040557065 countsByYear W30405570652022 @default.
- W3040557065 countsByYear W30405570652023 @default.
- W3040557065 crossrefType "journal-article" @default.
- W3040557065 hasAuthorship W3040557065A5003199141 @default.
- W3040557065 hasAuthorship W3040557065A5004590479 @default.
- W3040557065 hasAuthorship W3040557065A5012677271 @default.
- W3040557065 hasAuthorship W3040557065A5021133499 @default.
- W3040557065 hasAuthorship W3040557065A5026465169 @default.
- W3040557065 hasAuthorship W3040557065A5029728251 @default.
- W3040557065 hasAuthorship W3040557065A5034167556 @default.
- W3040557065 hasAuthorship W3040557065A5034711601 @default.
- W3040557065 hasAuthorship W3040557065A5037351209 @default.
- W3040557065 hasAuthorship W3040557065A5038069675 @default.
- W3040557065 hasAuthorship W3040557065A5041585576 @default.
- W3040557065 hasAuthorship W3040557065A5041856800 @default.
- W3040557065 hasAuthorship W3040557065A5043102433 @default.
- W3040557065 hasAuthorship W3040557065A5043840854 @default.
- W3040557065 hasAuthorship W3040557065A5044837743 @default.
- W3040557065 hasAuthorship W3040557065A5048810295 @default.