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• W3040569673 abstract "Abstract Background: COVID-19 has rapidly spread worldwide; however, the prognostic factors of COVID-19 have not been well described. Based on the prospective medical records in a secondary epidemic area, we examined the epidemiological, clinical characteristics, and explored the prognostic factors of COVID-19 patients. Methods: This retrospective, multi-center cohort study included consecutive cases with laboratory-confirmed COVID-19 from January 22 to February 22, 2020 in Wenzhou, China. All cases were followed up to discharge, death, or up to March 16, 2020. Demographic, clinical, laboratory, treatment, and prognosis data were extracted with standardized form, and compared between severe and non-severe cases. Logistic regression and Cox regression were used to explore the factors associated with ICU admission and hospital stay, respectively. Results: The epidemic curve showed that the duration of the whole epidemic in this secondary epidemic area was relatively short. Of the 148 included cases, 29 were severe cases. The median age was 52 years (range, 10–93 years), 62.2% were male, and 60.8% were overweight or obese. Fever (81.8%) and cough (61.5%) were the most common symptoms. Importantly, 25.0% had no clear contact history. The median length of hospital stay was 20 days (95%CI: 19–21), and 5.4% of patients were admitted to ICU, and one patient died. Compared with the non-severe cases, the severe patients were older, had a longer hospital stay, and had higher proportions of smoking, laboratory abnormalities, and ICU risk. Elevated alanine aminotransferase was independently associated with ICU admission; however, type of antiviral drugs had no significant association with duration of hospital stay. Older age, faster respiratory rate, smoking, and comorbidity tended to have higher risk of ICU admission and longer duration of hospital stay. Conclusions: The second-generation cases had atypical symptoms, and one quarter of cases had no clear contact history with cases, indicating the importance of strict preventive and control measures. Abnormal liver function, faster respiratory rate and smoking may be associated with worse prognosis of COVID-19; however, there was no convincing evidence for an association between antiviral therapy and length of hospital stay." @default.
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• W3040569673 date "2020-05-22" @default.
• W3040569673 modified "2023-10-02" @default.
• W3040569673 title "Clinical characteristics and prognostic factors of 148 COVID-19 cases in a secondary epidemic area" @default.
• W3040569673 doi "https://doi.org/10.21203/rs.3.rs-28362/v1" @default.
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