Matches in SemOpenAlex for { <https://semopenalex.org/work/W3040667429> ?p ?o ?g. }
- W3040667429 endingPage "2157" @default.
- W3040667429 startingPage "2147" @default.
- W3040667429 abstract "Background and purpose Different amounts of cumulative exposure to the toxic mutant form of the huntingtin protein might underlie the distinctive pattern of striatal connectivity in pre-manifest Huntington’s disease (pre-HD). The aim of this study was to investigate disease-burden-dependent cortical-striatal and subcortical-striatal loops at different pre-HD stages. Methods A total of 16 participants with pre-HD and 25 controls underwent magnetic resonance imaging to investigate striatal structural and functional connectivity (FC). Individuals with pre-HD were stratified into far-from-onset and close-to-onset disease groups according to the disease-burden score. Cortical-striatal and subcortical-striatal FC was investigated through seed-region of interest (ROI) and ROI-to-ROI approaches, respectively. The integrity of white-matter pathways originating from striatal seeds was investigated through probabilistic tractography. Results In far-from-onset pre-HD, the left caudate nucleus showed cortical increased FC in brain regions overlapping with the default mode network and increased coupling connectivity with the bilateral thalamus. By contrast, close-to-onset individuals showed increased fractional anisotropy (and mean diffusivity) in the right caudate nucleus and widespread striatal atrophy. Finally, we reported an association between cortical-caudate FC and caudate structural connectivity, although this did not survive multiple comparison correction. Conclusions Functional reorganization of the caudate nucleus might underlie plasticity compensatory mechanisms that recede as individuals with pre-HD approach clinical symptom onset and neurodegeneration." @default.
- W3040667429 created "2020-07-10" @default.
- W3040667429 creator A5010299644 @default.
- W3040667429 creator A5051568032 @default.
- W3040667429 creator A5055456048 @default.
- W3040667429 creator A5062641136 @default.
- W3040667429 creator A5067039699 @default.
- W3040667429 creator A5078873072 @default.
- W3040667429 date "2020-07-30" @default.
- W3040667429 modified "2023-10-10" @default.
- W3040667429 title "Striatal connectivity in pre‐manifest Huntington’s disease is differentially affected by disease burden" @default.
- W3040667429 cites W1179800764 @default.
- W3040667429 cites W1927762784 @default.
- W3040667429 cites W1983183519 @default.
- W3040667429 cites W1985367358 @default.
- W3040667429 cites W2002885460 @default.
- W3040667429 cites W2006952111 @default.
- W3040667429 cites W2011502145 @default.
- W3040667429 cites W2020117714 @default.
- W3040667429 cites W2048228346 @default.
- W3040667429 cites W2078320135 @default.
- W3040667429 cites W2080744166 @default.
- W3040667429 cites W2094735076 @default.
- W3040667429 cites W2103717170 @default.
- W3040667429 cites W2111221422 @default.
- W3040667429 cites W2113661629 @default.
- W3040667429 cites W2113872322 @default.
- W3040667429 cites W2124480185 @default.
- W3040667429 cites W2124660038 @default.
- W3040667429 cites W2126838454 @default.
- W3040667429 cites W2515702256 @default.
- W3040667429 cites W2591684650 @default.
- W3040667429 cites W2606710341 @default.
- W3040667429 cites W2651814656 @default.
- W3040667429 cites W2756791650 @default.
- W3040667429 cites W2765279839 @default.
- W3040667429 cites W2770942592 @default.
- W3040667429 cites W2789419405 @default.
- W3040667429 cites W2800683419 @default.
- W3040667429 cites W2803113191 @default.
- W3040667429 cites W2911444243 @default.
- W3040667429 cites W2922259075 @default.
- W3040667429 cites W2949824402 @default.
- W3040667429 cites W2968859363 @default.
- W3040667429 cites W2973870617 @default.
- W3040667429 cites W2980498570 @default.
- W3040667429 cites W2982282480 @default.
- W3040667429 cites W2995276946 @default.
- W3040667429 doi "https://doi.org/10.1111/ene.14423" @default.
- W3040667429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32602565" @default.
- W3040667429 hasPublicationYear "2020" @default.
- W3040667429 type Work @default.
- W3040667429 sameAs 3040667429 @default.
- W3040667429 citedByCount "6" @default.
- W3040667429 countsByYear W30406674292020 @default.
- W3040667429 countsByYear W30406674292021 @default.
- W3040667429 countsByYear W30406674292022 @default.
- W3040667429 countsByYear W30406674292023 @default.
- W3040667429 crossrefType "journal-article" @default.
- W3040667429 hasAuthorship W3040667429A5010299644 @default.
- W3040667429 hasAuthorship W3040667429A5051568032 @default.
- W3040667429 hasAuthorship W3040667429A5055456048 @default.
- W3040667429 hasAuthorship W3040667429A5062641136 @default.
- W3040667429 hasAuthorship W3040667429A5067039699 @default.
- W3040667429 hasAuthorship W3040667429A5078873072 @default.
- W3040667429 hasBestOaLocation W30406674293 @default.
- W3040667429 hasConcept C126838900 @default.
- W3040667429 hasConcept C142724271 @default.
- W3040667429 hasConcept C143409427 @default.
- W3040667429 hasConcept C149550507 @default.
- W3040667429 hasConcept C169760540 @default.
- W3040667429 hasConcept C2776925932 @default.
- W3040667429 hasConcept C2778187257 @default.
- W3040667429 hasConcept C2779134260 @default.
- W3040667429 hasConcept C2779246727 @default.
- W3040667429 hasConcept C2779714222 @default.
- W3040667429 hasConcept C2780062018 @default.
- W3040667429 hasConcept C2780647506 @default.
- W3040667429 hasConcept C2781172350 @default.
- W3040667429 hasConcept C2781192897 @default.
- W3040667429 hasConcept C2781423529 @default.
- W3040667429 hasConcept C2781427258 @default.
- W3040667429 hasConcept C513476851 @default.
- W3040667429 hasConcept C529278444 @default.
- W3040667429 hasConcept C71924100 @default.
- W3040667429 hasConcept C86803240 @default.
- W3040667429 hasConcept C89916169 @default.
- W3040667429 hasConceptScore W3040667429C126838900 @default.
- W3040667429 hasConceptScore W3040667429C142724271 @default.
- W3040667429 hasConceptScore W3040667429C143409427 @default.
- W3040667429 hasConceptScore W3040667429C149550507 @default.
- W3040667429 hasConceptScore W3040667429C169760540 @default.
- W3040667429 hasConceptScore W3040667429C2776925932 @default.
- W3040667429 hasConceptScore W3040667429C2778187257 @default.
- W3040667429 hasConceptScore W3040667429C2779134260 @default.
- W3040667429 hasConceptScore W3040667429C2779246727 @default.
- W3040667429 hasConceptScore W3040667429C2779714222 @default.
- W3040667429 hasConceptScore W3040667429C2780062018 @default.