Matches in SemOpenAlex for { <https://semopenalex.org/work/W3040706705> ?p ?o ?g. }
- W3040706705 abstract "Abstract Hand, foot, and mouth disease (HFMD) is a common global epidemic. From 2008 onwards, many HFMD outbreaks caused by coxsackievirus A6 (CV-A6) have been reported worldwide. Since 2013, with a dramatically increasing number of CV-A6-related HFMD cases, CV-A6 has become the predominant HFMD pathogen in mainland China. Phylogenetic analysis based on the VP1 capsid gene revealed that subtype D3 dominated the CV-A6 outbreaks. Here, we performed a large-scale (near) full-length genetic analysis of global and Chinese CV-A6 variants, including 158 newly sequenced samples collected extensively in mainland China between 2010 and 2018. During the global transmission of subtype D3 of CV-A6, the noncapsid gene continued recombining, giving rise to a series of viable recombinant hybrids designated evolutionary lineages, and each lineage displayed internal consistency in both genetic and epidemiological features. The emergence of lineage –A since 2005 has triggered CV-A6 outbreaks worldwide, with a rate of evolution estimated at 4.17 × 10−3 substitutions site-1 year−1 based on a large number of monophyletic open reading frame sequences, and created a series of lineages chronologically through varied noncapsid recombination events. In mainland China, lineage –A has generated another two novel widespread lineages (–J and –L) through recombination within the enterovirus A gene pool, with robust estimates of occurrence time. Lineage –A, –J, and –L infections presented dissimilar clinical manifestations, indicating that the conservation of the CV-A6 capsid gene resulted in high transmissibility, but the lineage-specific noncapsid gene might influence pathogenicity. Potentially important amino acid substitutions were further predicted among CV-A6 variants. The evolutionary phenomenon of noncapsid polymorphism within the same subtype observed in CV-A6 was uncommon in other leading HFMD pathogens; such frequent recombination happened in fast-spreading CV-A6, indicating that the recovery of deleterious genomes may still be ongoing within CV-A6 quasispecies. CV-A6-related HFMD outbreaks have caused a significant public health burden and pose a great threat to children’s health; therefore, further surveillance is greatly needed to understand the full genetic diversity of CV-A6 in mainland China." @default.
- W3040706705 created "2020-07-16" @default.
- W3040706705 creator A5000628009 @default.
- W3040706705 creator A5000794709 @default.
- W3040706705 creator A5000871229 @default.
- W3040706705 creator A5020924102 @default.
- W3040706705 creator A5024817445 @default.
- W3040706705 creator A5031648108 @default.
- W3040706705 creator A5042560788 @default.
- W3040706705 creator A5043112987 @default.
- W3040706705 creator A5049434220 @default.
- W3040706705 creator A5051624563 @default.
- W3040706705 creator A5056848310 @default.
- W3040706705 creator A5066078929 @default.
- W3040706705 creator A5066989731 @default.
- W3040706705 creator A5067098140 @default.
- W3040706705 creator A5074278109 @default.
- W3040706705 creator A5074529705 @default.
- W3040706705 creator A5075812383 @default.
- W3040706705 creator A5078722034 @default.
- W3040706705 creator A5088700209 @default.
- W3040706705 creator A5088949422 @default.
- W3040706705 date "2020-07-01" @default.
- W3040706705 modified "2023-10-18" @default.
- W3040706705 title "Genetic recombination in fast-spreading coxsackievirus A6 variants: a potential role in evolution and pathogenicity" @default.
- W3040706705 cites W1491886987 @default.
- W3040706705 cites W1508906948 @default.
- W3040706705 cites W1518111649 @default.
- W3040706705 cites W1587094243 @default.
- W3040706705 cites W1615349236 @default.
- W3040706705 cites W1966965406 @default.
- W3040706705 cites W1969042907 @default.
- W3040706705 cites W1974210601 @default.
- W3040706705 cites W1975586522 @default.
- W3040706705 cites W1990096140 @default.
- W3040706705 cites W1992147205 @default.
- W3040706705 cites W1995961101 @default.
- W3040706705 cites W1996242706 @default.
- W3040706705 cites W2007886044 @default.
- W3040706705 cites W2013339538 @default.
- W3040706705 cites W2013491640 @default.
- W3040706705 cites W2013518376 @default.
- W3040706705 cites W2021430546 @default.
- W3040706705 cites W2026706600 @default.
- W3040706705 cites W2029062056 @default.
- W3040706705 cites W2036658289 @default.
- W3040706705 cites W2042361543 @default.
- W3040706705 cites W2044969390 @default.
- W3040706705 cites W2061604108 @default.
- W3040706705 cites W2067146710 @default.
- W3040706705 cites W2091667222 @default.
- W3040706705 cites W2100008113 @default.
- W3040706705 cites W2110835349 @default.
- W3040706705 cites W2110969286 @default.
- W3040706705 cites W2118927114 @default.
- W3040706705 cites W2118982822 @default.
- W3040706705 cites W2124063640 @default.
- W3040706705 cites W2125411106 @default.
- W3040706705 cites W2128322048 @default.
- W3040706705 cites W2130457842 @default.
- W3040706705 cites W2132759965 @default.
- W3040706705 cites W2132936904 @default.
- W3040706705 cites W2134683222 @default.
- W3040706705 cites W2137694608 @default.
- W3040706705 cites W2141052558 @default.
- W3040706705 cites W2142196041 @default.
- W3040706705 cites W2149555680 @default.
- W3040706705 cites W2151051975 @default.
- W3040706705 cites W2158266834 @default.
- W3040706705 cites W2159093669 @default.
- W3040706705 cites W2162318638 @default.
- W3040706705 cites W2165685710 @default.
- W3040706705 cites W2166648201 @default.
- W3040706705 cites W2194837652 @default.
- W3040706705 cites W2311203695 @default.
- W3040706705 cites W2320312660 @default.
- W3040706705 cites W2322358787 @default.
- W3040706705 cites W2329349905 @default.
- W3040706705 cites W2334359746 @default.
- W3040706705 cites W237882867 @default.
- W3040706705 cites W2401986311 @default.
- W3040706705 cites W2414304625 @default.
- W3040706705 cites W2417404085 @default.
- W3040706705 cites W2420312423 @default.
- W3040706705 cites W2470165008 @default.
- W3040706705 cites W2485244923 @default.
- W3040706705 cites W2525698242 @default.
- W3040706705 cites W2558701369 @default.
- W3040706705 cites W2607489428 @default.
- W3040706705 cites W2721124202 @default.
- W3040706705 cites W2734584211 @default.
- W3040706705 cites W2735543711 @default.
- W3040706705 cites W2753655819 @default.
- W3040706705 cites W2755331695 @default.
- W3040706705 cites W2765612190 @default.
- W3040706705 cites W2770588646 @default.
- W3040706705 cites W2789451687 @default.
- W3040706705 cites W2793282196 @default.
- W3040706705 cites W2810741527 @default.
- W3040706705 cites W2889698866 @default.