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- W3040714102 abstract "Abstract Purpose of Review Chronic hepatitis B (CHB), caused by hepatitis B virus (HBV), is a major cause of advanced liver disease and hepatocellular carcinoma (HCC) worldwide. HBV replication is characterized by the synthesis of covalently closed circular (ccc) DNA which is not targeted by antiviral nucleos(t)ide analogues (NUCs) the key modality of standard of care. While HBV replication is successfully suppressed in treated patients, they remain at risk for developing HCC. While functional cure, characterized by loss of HBsAg, is the first goal of novel antiviral therapies, curative treatments eliminating cccDNA remain the ultimate goal. This review summarizes recent advances in the discovery and development of novel therapeutic strategies and their impact on cccDNA biology. Recent Findings Within the last decade, substantial progress has been made in the understanding of cccDNA biology including the discovery of host dependency factors, epigenetic regulation of cccDNA transcription and immune-mediated degradation. Several approaches targeting cccDNA either in a direct or indirect manner are currently at the stage of discovery, preclinical or early clinical development. Examples include genome-editing approaches, strategies targeting host dependency factors or epigenetic gene regulation, nucleocapsid modulators and immune-mediated degradation. Summary While direct-targeting cccDNA strategies are still largely at the preclinical stage of development, capsid assembly modulators and immune-based approaches have reached the clinical phase. Clinical trials are ongoing to assess their efficacy and safety in patients including their impact on viral cccDNA. Combination therapies provide additional opportunities to overcome current limitations of individual approaches." @default.
- W3040714102 created "2020-07-16" @default.
- W3040714102 creator A5008863049 @default.
- W3040714102 creator A5030236783 @default.
- W3040714102 creator A5046107209 @default.
- W3040714102 date "2020-07-10" @default.
- W3040714102 modified "2023-10-18" @default.
- W3040714102 title "Targeting Viral cccDNA for Cure of Chronic Hepatitis B" @default.
- W3040714102 cites W1676377504 @default.
- W3040714102 cites W1799137450 @default.
- W3040714102 cites W1844576826 @default.
- W3040714102 cites W1918954877 @default.
- W3040714102 cites W1931958712 @default.
- W3040714102 cites W1934998482 @default.
- W3040714102 cites W1959120593 @default.
- W3040714102 cites W1969776963 @default.
- W3040714102 cites W1972992218 @default.
- W3040714102 cites W1974551062 @default.
- W3040714102 cites W1980896697 @default.
- W3040714102 cites W1982255712 @default.
- W3040714102 cites W1988615815 @default.
- W3040714102 cites W1988787951 @default.
- W3040714102 cites W1997866877 @default.
- W3040714102 cites W1999770898 @default.
- W3040714102 cites W2003692477 @default.
- W3040714102 cites W2010358693 @default.
- W3040714102 cites W2011555137 @default.
- W3040714102 cites W2012025617 @default.
- W3040714102 cites W2012150396 @default.
- W3040714102 cites W2014080406 @default.
- W3040714102 cites W2015763479 @default.
- W3040714102 cites W2027555120 @default.
- W3040714102 cites W2032841947 @default.
- W3040714102 cites W2037524921 @default.
- W3040714102 cites W2042396550 @default.
- W3040714102 cites W2043861742 @default.
- W3040714102 cites W2051173965 @default.
- W3040714102 cites W2053744043 @default.
- W3040714102 cites W2063549241 @default.
- W3040714102 cites W2064815984 @default.
- W3040714102 cites W2065281664 @default.
- W3040714102 cites W2070614858 @default.
- W3040714102 cites W2075587088 @default.
- W3040714102 cites W2075849830 @default.
- W3040714102 cites W2077172281 @default.
- W3040714102 cites W2078828237 @default.
- W3040714102 cites W2088160623 @default.
- W3040714102 cites W2088474579 @default.
- W3040714102 cites W2092193247 @default.
- W3040714102 cites W2120376917 @default.
- W3040714102 cites W2120426460 @default.
- W3040714102 cites W2129105278 @default.
- W3040714102 cites W2153157375 @default.
- W3040714102 cites W2154097176 @default.
- W3040714102 cites W2167203718 @default.
- W3040714102 cites W2184000192 @default.
- W3040714102 cites W2221555640 @default.
- W3040714102 cites W2286337224 @default.
- W3040714102 cites W2286872394 @default.
- W3040714102 cites W2298466016 @default.
- W3040714102 cites W2331003237 @default.
- W3040714102 cites W2337204897 @default.
- W3040714102 cites W2338215546 @default.
- W3040714102 cites W2468367608 @default.
- W3040714102 cites W2512857074 @default.
- W3040714102 cites W2523441707 @default.
- W3040714102 cites W2541628542 @default.
- W3040714102 cites W2547133566 @default.
- W3040714102 cites W2551376454 @default.
- W3040714102 cites W2580434951 @default.
- W3040714102 cites W2591155166 @default.
- W3040714102 cites W2599402605 @default.
- W3040714102 cites W2609780949 @default.
- W3040714102 cites W2611875906 @default.
- W3040714102 cites W2612362978 @default.
- W3040714102 cites W2612826819 @default.
- W3040714102 cites W2618110836 @default.
- W3040714102 cites W2622834744 @default.
- W3040714102 cites W2713927065 @default.
- W3040714102 cites W2739640246 @default.
- W3040714102 cites W2741613742 @default.
- W3040714102 cites W2754081264 @default.
- W3040714102 cites W2759319254 @default.
- W3040714102 cites W2774064974 @default.
- W3040714102 cites W2778928474 @default.
- W3040714102 cites W2780354497 @default.
- W3040714102 cites W2784444349 @default.
- W3040714102 cites W2785853755 @default.
- W3040714102 cites W2787915452 @default.
- W3040714102 cites W2790373237 @default.
- W3040714102 cites W2793070915 @default.
- W3040714102 cites W2796491062 @default.
- W3040714102 cites W2800975837 @default.
- W3040714102 cites W2801167100 @default.
- W3040714102 cites W2802735540 @default.
- W3040714102 cites W2805832713 @default.
- W3040714102 cites W2807436290 @default.
- W3040714102 cites W2807904488 @default.