FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3040721241> ?p ?o ?g. }

• W3040721241 abstract "Abstract Background Brain aging is a major risk factor in the progression of cognitive diseases including Alzheimer’s disease (AD) and vascular dementia. We investigated a mouse model of brain aging up to 24 months old (mo). Methods A high field (11.7T) MRI protocol was developed to characterize specific features of brain aging including the presence of cerebral microbleeds (CMBs), morphology of grey and white matter, and tissue diffusion properties. Mice were selected from age categories of either young (3 mo), middle-aged (18 mo), or old (24 mo) and fed normal chow over the duration of the study. Mice were imaged in vivo with multimodal MRI, including conventional T2-weighted (T2W) and T2*-weighted (T2*W) imaging, followed by ex vivo diffusion-weighted imaging (DWI) and T2*W MR-microscopy to enhance the detection of microstructural features. Results Structural changes observed in the mouse brain with aging included reduced cortical grey matter volume and enlargement of the brain ventricles. A remarkable age-related change in the brains was the development of CMBs found starting at 18 mo and increasing in total volume at 24 mo, primarily in the thalamus. CMBs presence was confirmed with high resolution ex vivo MRI and histology. DWI detected further brain tissue changes in the aged mice including reduced fractional anisotropy, increased radial diffusion, increased mean diffusion, and changes in the white matter fibers visualized by color-coded tractography, including around a large cortical CMB. Conclusions The mouse is a valuable model of age-related vascular contributions to cognitive impairment and dementia (VCID). In composite, these methods and results reveal brain aging in older mice as a multifactorial process including CMBs and tissue diffusion alterations that can be well characterized by high field MRI." @default.
• W3040721241 created "2020-07-16" @default.
• W3040721241 creator A5016328588 @default.
• W3040721241 creator A5019941350 @default.
• W3040721241 creator A5028209802 @default.
• W3040721241 creator A5035920117 @default.
• W3040721241 creator A5060030134 @default.
• W3040721241 creator A5089078063 @default.
• W3040721241 date "2020-07-08" @default.
• W3040721241 modified "2023-10-14" @default.
• W3040721241 title "The brains of aged mice are characterized by altered tissue diffusion properties and cerebral microbleeds" @default.
• W3040721241 cites W1482502296 @default.
• W3040721241 cites W1581119831 @default.
• W3040721241 cites W1828874644 @default.
• W3040721241 cites W1964426997 @default.
• W3040721241 cites W1971548649 @default.
• W3040721241 cites W1972816297 @default.
• W3040721241 cites W1974103289 @default.
• W3040721241 cites W1974681848 @default.
• W3040721241 cites W1987202085 @default.
• W3040721241 cites W1996167719 @default.
• W3040721241 cites W1996347415 @default.
• W3040721241 cites W2000179308 @default.
• W3040721241 cites W2004006028 @default.
• W3040721241 cites W2013859768 @default.
• W3040721241 cites W2015669295 @default.
• W3040721241 cites W2016246486 @default.
• W3040721241 cites W2026812901 @default.
• W3040721241 cites W2027272551 @default.
• W3040721241 cites W2032698104 @default.
• W3040721241 cites W2037426713 @default.
• W3040721241 cites W2038003677 @default.
• W3040721241 cites W2038072430 @default.
• W3040721241 cites W2046699283 @default.
• W3040721241 cites W2047538260 @default.
• W3040721241 cites W2047679742 @default.
• W3040721241 cites W2050683965 @default.
• W3040721241 cites W2058852522 @default.
• W3040721241 cites W2060467098 @default.
• W3040721241 cites W2063001897 @default.
• W3040721241 cites W2075260562 @default.
• W3040721241 cites W2079041835 @default.
• W3040721241 cites W2084439196 @default.
• W3040721241 cites W2091579936 @default.
• W3040721241 cites W2103069600 @default.
• W3040721241 cites W2113366456 @default.
• W3040721241 cites W2117854054 @default.
• W3040721241 cites W2120259577 @default.
• W3040721241 cites W2120265621 @default.
• W3040721241 cites W2122410839 @default.
• W3040721241 cites W2124210220 @default.
• W3040721241 cites W2139898307 @default.
• W3040721241 cites W2145396188 @default.
• W3040721241 cites W2147047643 @default.
• W3040721241 cites W2148568506 @default.
• W3040721241 cites W2149133024 @default.
• W3040721241 cites W2171776741 @default.
• W3040721241 cites W2179561038 @default.
• W3040721241 cites W2275656553 @default.
• W3040721241 cites W2322340227 @default.
• W3040721241 cites W2331242735 @default.
• W3040721241 cites W2374589510 @default.
• W3040721241 cites W2410623364 @default.
• W3040721241 cites W2468438354 @default.
• W3040721241 cites W2508694230 @default.
• W3040721241 cites W2596307749 @default.
• W3040721241 cites W2605145257 @default.
• W3040721241 cites W2759050422 @default.
• W3040721241 cites W2767076030 @default.
• W3040721241 cites W2786608785 @default.
• W3040721241 cites W2790427241 @default.
• W3040721241 cites W2791004575 @default.
• W3040721241 cites W2803306216 @default.
• W3040721241 cites W2805432993 @default.
• W3040721241 cites W2884070641 @default.
• W3040721241 cites W2900473259 @default.
• W3040721241 cites W2901329269 @default.
• W3040721241 cites W2911147760 @default.
• W3040721241 cites W2971164718 @default.
• W3040721241 cites W4231345253 @default.
• W3040721241 cites W4250162811 @default.
• W3040721241 doi "https://doi.org/10.1186/s12967-020-02441-6" @default.
• W3040721241 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7346388" @default.
• W3040721241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32641073" @default.
• W3040721241 hasPublicationYear "2020" @default.
• W3040721241 type Work @default.
• W3040721241 sameAs 3040721241 @default.
• W3040721241 citedByCount "12" @default.
• W3040721241 countsByYear W30407212412020 @default.
• W3040721241 countsByYear W30407212412021 @default.
• W3040721241 countsByYear W30407212412022 @default.
• W3040721241 countsByYear W30407212412023 @default.
• W3040721241 crossrefType "journal-article" @default.
• W3040721241 hasAuthorship W3040721241A5016328588 @default.
• W3040721241 hasAuthorship W3040721241A5019941350 @default.
• W3040721241 hasAuthorship W3040721241A5028209802 @default.
• W3040721241 hasAuthorship W3040721241A5035920117 @default.
• W3040721241 hasAuthorship W3040721241A5060030134 @default.
• W3040721241 hasAuthorship W3040721241A5089078063 @default.
• W3040721241 hasBestOaLocation W30407212411 @default.

• next