FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3040734208> ?p ?o ?g. }

• W3040734208 endingPage "260" @default.
• W3040734208 startingPage "256" @default.
• W3040734208 abstract "223Ra-dichloride is a bone-seeking targeted alpha (α)-emitting approved for bone metastases in prostate cancer. Here, we report a case of therapy-related acute promyelocytic leukemia (t-APL) following administration of 223Ra, showing some evidence of a causative relationship. A patient with metastatic prostate cancer received therapy with 223Ra, with 6 injections of the radiopharmaceutical at a standard dose of 55 kBq/kg at 4-week intervals for a cumulative administered activity of 26.3 MBq. PET/CT with 18F-methylcholine repeated 1 month after the conclusion of 223Ra was negative. After 8 months, he developed pancytopenia and we made a diagnosis of therapy-related acute promyelocytic leukemia (t-APL). We then studied the genomic locations of the breakpoints in the PML and RARA genes, which were at nucleotide positions 1708-09 of PML intron 3, respectively, outside the previously reported Topo II-associated hotspot region. t-APL was cured with all-trans-retinoic acid (ATRA) and arsenic trioxide. The type of PML/RARA rearrangement we identified, in absence of other myelotoxic treatments, is suggestive of a possible direct causal relationship with exposure to 223Ra and warrants further investigations." @default.
• W3040734208 created "2020-07-16" @default.
• W3040734208 creator A5019371574 @default.
• W3040734208 creator A5020082749 @default.
• W3040734208 creator A5024587881 @default.
• W3040734208 creator A5033637751 @default.
• W3040734208 creator A5047293283 @default.
• W3040734208 creator A5063825892 @default.
• W3040734208 creator A5071887200 @default.
• W3040734208 creator A5086920822 @default.
• W3040734208 creator A5088682160 @default.
• W3040734208 date "2020-07-09" @default.
• W3040734208 modified "2023-09-23" @default.
• W3040734208 title "Acute Promyelocytic Leukemia After Radium-223 Exposure for Prostate Cancer in a Chemotherapy-Naïve Patient" @default.
• W3040734208 cites W2005557419 @default.
• W3040734208 cites W2010828491 @default.
• W3040734208 cites W2016132084 @default.
• W3040734208 cites W2048926087 @default.
• W3040734208 cites W2067578884 @default.
• W3040734208 cites W2084414912 @default.
• W3040734208 cites W2092223900 @default.
• W3040734208 cites W2098494369 @default.
• W3040734208 cites W2111724321 @default.
• W3040734208 cites W2113371461 @default.
• W3040734208 cites W2120811574 @default.
• W3040734208 cites W2137583404 @default.
• W3040734208 cites W2141454098 @default.
• W3040734208 cites W2148643283 @default.
• W3040734208 cites W2557527058 @default.
• W3040734208 cites W2567171443 @default.
• W3040734208 cites W2600261757 @default.
• W3040734208 cites W2793025896 @default.
• W3040734208 cites W2909895382 @default.
• W3040734208 cites W2994845187 @default.
• W3040734208 doi "https://doi.org/10.1007/s13139-020-00652-9" @default.
• W3040734208 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7560650" @default.
• W3040734208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33088356" @default.
• W3040734208 hasPublicationYear "2020" @default.
• W3040734208 type Work @default.
• W3040734208 sameAs 3040734208 @default.
• W3040734208 citedByCount "1" @default.
• W3040734208 countsByYear W30407342082022 @default.
• W3040734208 crossrefType "journal-article" @default.
• W3040734208 hasAuthorship W3040734208A5019371574 @default.
• W3040734208 hasAuthorship W3040734208A5020082749 @default.
• W3040734208 hasAuthorship W3040734208A5024587881 @default.
• W3040734208 hasAuthorship W3040734208A5033637751 @default.
• W3040734208 hasAuthorship W3040734208A5047293283 @default.
• W3040734208 hasAuthorship W3040734208A5063825892 @default.
• W3040734208 hasAuthorship W3040734208A5071887200 @default.
• W3040734208 hasAuthorship W3040734208A5086920822 @default.
• W3040734208 hasAuthorship W3040734208A5088682160 @default.
• W3040734208 hasBestOaLocation W30407342082 @default.
• W3040734208 hasConcept C104317684 @default.
• W3040734208 hasConcept C121608353 @default.
• W3040734208 hasConcept C126322002 @default.
• W3040734208 hasConcept C143998085 @default.
• W3040734208 hasConcept C190283241 @default.
• W3040734208 hasConcept C2776601000 @default.
• W3040734208 hasConcept C2777783956 @default.
• W3040734208 hasConcept C2778461978 @default.
• W3040734208 hasConcept C2779382419 @default.
• W3040734208 hasConcept C2780007613 @default.
• W3040734208 hasConcept C2780192828 @default.
• W3040734208 hasConcept C2780386689 @default.
• W3040734208 hasConcept C2780737065 @default.
• W3040734208 hasConcept C2781121885 @default.
• W3040734208 hasConcept C502942594 @default.
• W3040734208 hasConcept C54355233 @default.
• W3040734208 hasConcept C71924100 @default.
• W3040734208 hasConcept C86803240 @default.
• W3040734208 hasConceptScore W3040734208C104317684 @default.
• W3040734208 hasConceptScore W3040734208C121608353 @default.
• W3040734208 hasConceptScore W3040734208C126322002 @default.
• W3040734208 hasConceptScore W3040734208C143998085 @default.
• W3040734208 hasConceptScore W3040734208C190283241 @default.
• W3040734208 hasConceptScore W3040734208C2776601000 @default.
• W3040734208 hasConceptScore W3040734208C2777783956 @default.
• W3040734208 hasConceptScore W3040734208C2778461978 @default.
• W3040734208 hasConceptScore W3040734208C2779382419 @default.
• W3040734208 hasConceptScore W3040734208C2780007613 @default.
• W3040734208 hasConceptScore W3040734208C2780192828 @default.
• W3040734208 hasConceptScore W3040734208C2780386689 @default.
• W3040734208 hasConceptScore W3040734208C2780737065 @default.
• W3040734208 hasConceptScore W3040734208C2781121885 @default.
• W3040734208 hasConceptScore W3040734208C502942594 @default.
• W3040734208 hasConceptScore W3040734208C54355233 @default.
• W3040734208 hasConceptScore W3040734208C71924100 @default.
• W3040734208 hasConceptScore W3040734208C86803240 @default.
• W3040734208 hasIssue "5" @default.
• W3040734208 hasLocation W30407342081 @default.
• W3040734208 hasLocation W30407342082 @default.
• W3040734208 hasLocation W30407342083 @default.
• W3040734208 hasOpenAccess W3040734208 @default.
• W3040734208 hasPrimaryLocation W30407342081 @default.
• W3040734208 hasRelatedWork W122177069 @default.
• W3040734208 hasRelatedWork W2021751111 @default.
• W3040734208 hasRelatedWork W2024067364 @default.

• next