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- W3040753893 abstract "Objective: To investigate the characteristics of comorbidities and polypharmacy in middle-aged and elderly patients and assess the potential risk of drug-drug interactions. Methods: Retrospective analysis was carried out among the outpatients aged ≥45 years in the Second Medical Center of the PLA General Hospital from January to December 2016. The patient's comorbidities and polypharmacy were collected from the electronic medical records and annual physical examination reports. The frequency and grade of drug-drug interactions (DDIs) were summarized and ranked by Lexicomp(®) Drug Interactions database. Results: A total of 1 340 patients were enrolled in the study, of which 930 patients (69.40%) used 5 or more drugs, and 660 patients (49.25%) used 10 or more drugs. Multivariate analysis showed that age and the number of comorbidities were independent factors of excessive polypharmacy. The total frequency of detecting clinically significant DDIs (C+D+X) was 857 cases, with 0.8 cases per person by Lexicomp(®) Drug Interactions database. Among them, medications for nervous system accounted for the highest proportion of X-level DDIs. Conclusions: The comorbidities and polypharmacy in middle-aged and elderly patients are very prominent. More attention should be paid to drug interactions, especially in patients with neurological medication.目的： 分析中老年患者共病及多重用药的特征，评估潜在药物间相互作用（DDIs）的风险。 方法： 回顾性分析2016年1至12月解放军总医院第二医学中心年龄≥45岁门诊长期随诊患者，利用门诊电子病历及年度查体报告收集患者共病及多重用药情况，通过Lexicomp(®) Drug Interactions数据库分析其DDIs的发生频次及等级，进行归纳、排序，并分析其临床特征。 结果： 研究共纳入1 340例患者，其中930例（69.40%）使用5种及5种以上的药物，660例（49.25%）使用≥10种的药物。多因素分析显示年龄、共病数量是过度多重用药的独立影响因素。纳入Lexicomp(®) Drug Interactions数据库分析药品共计120种，检出具有临床意义的DDIs（C+D+X级）频次为857例次，平均总检出频次为0.8次/人。其中，X级别的DDIs以神经系统用药占比最高。 结论： 中老年患者共病及多重用药现象非常突出，DDIs的潜在风险普遍存在，对于有神经系统用药者要尤其重视。." @default.
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- W3040753893 date "2020-07-07" @default.
- W3040753893 modified "2023-09-27" @default.
- W3040753893 title "[Analysis of comorbidity and polypharmacy in middle-aged and elderly patients]." @default.
- W3040753893 doi "https://doi.org/10.3760/cma.j.cn112137-20200403-01066" @default.
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