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• W3040759957 abstract "ABSTRACT Objectives We propose and evaluate a system for assessing severity of ZikV-related microcephaly brain abnormalities called RaRe (Radiological Reading score). The system is a combination of neuroradiologist evaluation scores; we also propose and evaluate its semi-automated version, which is generated from MRI indices. Design We carried out a cross-sectional study with retrospective data collection at birth and 13-39 months; data collection includes radiologists evaluation of MRI images and a semi-automated system for analyzing MRI images from ZikV-related microcephaly patients; we also evaluated the association of severity and RaRe scores with developmental outcomes. Setting Brain Institute of Rio Grande do Sul and Memorial Hospital Arthur Ramos, both in Brazil. Participants 42 infants with ZikV-related congenital microcephaly (age at second evaluation M = 24.83 months; SD = 5.82). Mothers were infected by Zika Virus during pregnancy and were symptomatic or asymptomatic. Main outcome measures Clinical and radiological outcomes (blindly reviewed); severity classification system (semi-automated – RaRe-Auto or based on neuroradiological evaluation RaRe-Clin) and association with developmental outcomes (Bayley-III scales). Results RaRe-Clin positively correlated with RaRe-Auto (r = 0.892; p < 0.001). Severity negatively associated with neurodevelopment scores assessed by Bayley-III scales in all three domains: cognition, language and motor skills. There was no association between trimester of infection and head circumference at birth (r = 0.160; p = 0.338) but there was an association between trimester of infection and RaRe-Clin (r = -0.355; p = 0.029). Conclusions The clinical and semi-automated RaRe scores predicted Bayley scores. RaRe-Clin and RaRe-Auto can predict the trimester of infection and severity of outcomes and should be investigated in their further application with other congenital and infection-related brain abnormalities. What is already known on this topic Congenital ZikV infection is associated with increased risk for microcephaly; Microcephaly is associated with severe cognitive deficits and brain abnormalities; Head circumference at birth < 32 cm establishes the diagnosis of microcephaly but other indices are needed to glean information about severity of abnormalities and prognoses What this study adds We propose a composite scoring system (RaRe) and system for grouping patients according to severity of microcephaly based on clinical indices (radiological readings of microcephaly; RaRe-Clin) and semi-automated MRI-based scores (RaRe-Auto). The proposed scoring systems are associated with developmental outcomes associated with ZikV-related microcephaly and trimester of infection and may help inform the prognosis of ZikaV-related microcephaly;" @default.
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• W3040759957 date "2020-07-10" @default.
• W3040759957 modified "2023-10-16" @default.
• W3040759957 title "Brain Malformations in Zika Virus Related Congenital Microcephaly: interactions among clinical and imaging scores and a semi-automated classification of severity based on MRI indices (RaRe - Radiological Reading score)" @default.
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• W3040759957 doi "https://doi.org/10.1101/2020.07.08.20149120" @default.
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