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• W3040762451 abstract "Recently, MOTS-c, a mitochondrial-derived peptide with effects on metabolic health, was identified. However, few data exist in humans including factors that affect circulating concentrations. PURPOSE: The aim of this study was to discern if serum MOTS-c concentrations were different between physically active and inactive young and older adults, or affected by cardiorespiratory fitness, body composition, hemoglobin A1c (HbA1c), and sex. METHODS: Forty-one healthy Young (18 – 30 yrs; n=26) and Older (55 – 70 yrs; n=15) adults participated in the study. Young and Older groups were further divided into Active and Inactive groups. Serum MOTS-c concentrations, maximum oxygen consumption (VO2max), body composition, and HbA1c were measured. Independent student’s t-tests were performed to determine group mean differences in serum MOTS-c concentrations between: Young and Older groups, Active and Inactive Young, Active and Inactive Older, males and females, Young males and females, and Older males and females. An α-level of ≤ 0.05 was set a priori. Pearson’s correlations were performed between MOTS-c concentrations and the following: VO2max, HbA1c, percent body fat, fat mass, and lean mass RESULTS: There were no differences in serum MOTS-c concentrations between Young and Older subjects, between Active Young and Inactive Young or Active Older and Inactive Older subjects. Serum MOTS-c was also not correlated with VO2max, percent body fat, lean body mass, fat mass or HbA1c, which were in normal ranges. When sexes were analyzed separately, MOTS-c levels in Older females were significantly higher than Older males (419.9±43.3 vs 354.0±63.7 ng/mL, respectively; p=0.03). These findings suggest that circulating MOTS-c concentrations are not affected by physical activity status, cardiorespiratory fitness, body composition, or normal HbA1c in healthy young and older adults, however, vary between sexes in older adults." @default.
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• W3040762451 date "2020-07-01" @default.
• W3040762451 modified "2023-09-27" @default.
• W3040762451 title "Serum MOTS-c Concentrations Are Higher In Older Females Compared To Older Males But Is Not Affected By Physical Activity Status Or Cardiorespiratory Fitness In Young And Older Adults" @default.
• W3040762451 doi "https://doi.org/10.1249/01.mss.0000687352.60611.08" @default.
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