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- W3040780907 abstract "Oxaliplatin containing chemotherapy is known to induce HSOS, which is also expressed by its appearance as blue liver syndrome. HSOS has been reported to increase morbidity and mortality in surgical patients (pts), and thus, its extent could affect treatment outcomes. However, the assessment of its severity solely depends on laboratory findings of hepatic indices, and the quantitative evaluation of HSOS is not sufficient in clinical use. The purpose of this study is to construct a non-invasive prediction model for HSOS by applying radiomics which provides a comprehensive quantification of CT image textures. We retrospectively analyzed 32 colorectal cancer patients treated in our hospital from November 2011 to May 2017. There were 16 males and 16 females with a mean age of 64.3 (38-81). These 32 pts consisted of two sub-groups; 16 HSOS-positive pts with abnormal hepatic indices who underwent oxaliplatin containing chemotherapy, and 16 HSOS-negative pts with normal hepatic laboratory findings who did not have any oxaliplatin chemotherapy. The whole liver was semi-automatically delineated. 38 radiomic features were extracted by LIFEx software (www.lifexsoft.org). Feature extractions were performed, first by a univariate analysis by Wilcoxon rank-sum test, followed by multivariate logistic regression analysis with a step-wise feature-reduction. ROC (receiver operating characteristic) analysis was performed to generate the radiomic signature for the assessment of HSOS. The radiomic signature demonstrated high discriminatory performance in predicting HSOS with an area under the curve (AUC) of 0.949 with a sensitivity of 93.75% and specificity of 93.75% (P< 0.001). A prediction radiomic model for HSOS was generated successfully. In the next step, we would further refine and generalize its accuracy by adopting the external validation cohort of HSOS by oxaliplatin." @default.
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- W3040780907 date "2020-07-01" @default.
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- W3040780907 title "P-145 CT-based texture analysis using radiomics for hepatic sinusoidal obstruction syndrome (HSOS) in colorectal cancer patients treated with oxaliplatin containing chemotherapy" @default.
- W3040780907 doi "https://doi.org/10.1016/j.annonc.2020.04.227" @default.
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