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- W3040781008 abstract "The formulation of cell-based medicinal products (CBMPs) poses major challenges because of their complexity, heterogeneity, interaction with their environment (e.g., the formulation buffer, interfaces), and susceptibility to degradation. These challenges can be quality, safety, and efficacy related. In this commentary we discuss the current status in formulation strategies of off-the-shelf and non-off-the-shelf (patient-specific) CBMPs and highlight advantages and disadvantages of each strategy. Analytical tools for the characterization and stability assessment of CBMP formulations are addressed as well. Finally, we discuss unmet needs and make some recommendations regarding the formulation of CBMPs." @default.
- W3040781008 created "2020-07-16" @default.
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- W3040781008 date "2021-05-01" @default.
- W3040781008 modified "2023-10-11" @default.
- W3040781008 title "Formulation of Cell-Based Medicinal Products: A Question of Life or Death?" @default.
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- W3040781008 doi "https://doi.org/10.1016/j.xphs.2020.07.002" @default.
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