FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3040787704> ?p ?o ?g. }

• W3040787704 endingPage "105458" @default.
• W3040787704 startingPage "105458" @default.
• W3040787704 abstract "For poorly soluble compounds, drug product performance in patients with Ulcerative Colitis (UC) compared to healthy subjects can be affected due to differences in drug solubility in GI fluids. A risk assessment tool was developed to identify compounds with a high risk of altered solubility in the GI fluids of UC patients. Pathophysiological changes impacting on the composition of GI fluids in UC patients were considered and UC biorelevant media representative of the stomach, intestine and colon were developed based on biorelevant media based on healthy subjects and literature data using a Design of Experiment approach. The UC media were characterised and revealed differences in surface tension, osmolality and buffer capacity compared to media based on healthy subjects. The solubility of six drugs was investigated in UC biorelevant media and results were related to media- and drug-dependent factors. A lower drug solubility in UC intestinal media was observed for compounds with a high lipophilicity. In UC simulated colonic fluids, drug solubility was altered for ionisable compounds. Additionally, a higher solubility of neutral lipophilic drugs was observed in UC fasted state colonic media with increased concentrations of soluble proteins. The developed UC biorelevant media offer the possibility to identify the risk of altered drug solubilisation in UC patients without conducting expensive clinical trials. A high risk was related to drug ionization properties and lipophilicity in the current study with all investigated drugs showing differences in solubility in biorelevant media based on UC patients compared to healthy subjects." @default.
• W3040787704 created "2020-07-16" @default.
• W3040787704 creator A5018368088 @default.
• W3040787704 creator A5072811095 @default.
• W3040787704 creator A5078087258 @default.
• W3040787704 creator A5088996378 @default.
• W3040787704 date "2020-09-01" @default.
• W3040787704 modified "2023-10-18" @default.
• W3040787704 title "Gastrointestinal diseases and their impact on drug solubility: Ulcerative Colitis" @default.
• W3040787704 cites W1498305210 @default.
• W3040787704 cites W1499768710 @default.
• W3040787704 cites W1968360309 @default.
• W3040787704 cites W1968688544 @default.
• W3040787704 cites W1969507309 @default.
• W3040787704 cites W1970120001 @default.
• W3040787704 cites W1971302933 @default.
• W3040787704 cites W1974774407 @default.
• W3040787704 cites W1989738331 @default.
• W3040787704 cites W1995091230 @default.
• W3040787704 cites W1996452137 @default.
• W3040787704 cites W1996888759 @default.
• W3040787704 cites W2005249562 @default.
• W3040787704 cites W2011226144 @default.
• W3040787704 cites W2013350857 @default.
• W3040787704 cites W2021239718 @default.
• W3040787704 cites W2034613829 @default.
• W3040787704 cites W2036957591 @default.
• W3040787704 cites W2040332490 @default.
• W3040787704 cites W2042036047 @default.
• W3040787704 cites W2061481072 @default.
• W3040787704 cites W2063928570 @default.
• W3040787704 cites W2064115923 @default.
• W3040787704 cites W2064288191 @default.
• W3040787704 cites W2066238318 @default.
• W3040787704 cites W2071138535 @default.
• W3040787704 cites W2082338117 @default.
• W3040787704 cites W2087769341 @default.
• W3040787704 cites W2088961994 @default.
• W3040787704 cites W2090036350 @default.
• W3040787704 cites W2092638251 @default.
• W3040787704 cites W2093597086 @default.
• W3040787704 cites W2098722265 @default.
• W3040787704 cites W2100385705 @default.
• W3040787704 cites W2102567329 @default.
• W3040787704 cites W2117772089 @default.
• W3040787704 cites W2119168680 @default.
• W3040787704 cites W2151169687 @default.
• W3040787704 cites W2170742355 @default.
• W3040787704 cites W2188248802 @default.
• W3040787704 cites W2324743082 @default.
• W3040787704 cites W2424925421 @default.
• W3040787704 cites W2520702758 @default.
• W3040787704 cites W2560750864 @default.
• W3040787704 cites W2564974142 @default.
• W3040787704 cites W2799328227 @default.
• W3040787704 cites W2803302189 @default.
• W3040787704 cites W2811058527 @default.
• W3040787704 cites W2901612554 @default.
• W3040787704 cites W2958757303 @default.
• W3040787704 cites W2989786995 @default.
• W3040787704 cites W47417504 @default.
• W3040787704 doi "https://doi.org/10.1016/j.ejps.2020.105458" @default.
• W3040787704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32645424" @default.
• W3040787704 hasPublicationYear "2020" @default.
• W3040787704 type Work @default.
• W3040787704 sameAs 3040787704 @default.
• W3040787704 citedByCount "5" @default.
• W3040787704 countsByYear W30407877042020 @default.
• W3040787704 countsByYear W30407877042021 @default.
• W3040787704 countsByYear W30407877042022 @default.
• W3040787704 crossrefType "journal-article" @default.
• W3040787704 hasAuthorship W3040787704A5018368088 @default.
• W3040787704 hasAuthorship W3040787704A5072811095 @default.
• W3040787704 hasAuthorship W3040787704A5078087258 @default.
• W3040787704 hasAuthorship W3040787704A5088996378 @default.
• W3040787704 hasBestOaLocation W30407877042 @default.
• W3040787704 hasConcept C112705442 @default.
• W3040787704 hasConcept C126322002 @default.
• W3040787704 hasConcept C155574463 @default.
• W3040787704 hasConcept C178790620 @default.
• W3040787704 hasConcept C185592680 @default.
• W3040787704 hasConcept C201399114 @default.
• W3040787704 hasConcept C2779134260 @default.
• W3040787704 hasConcept C2780035454 @default.
• W3040787704 hasConcept C2780479503 @default.
• W3040787704 hasConcept C55493867 @default.
• W3040787704 hasConcept C71924100 @default.
• W3040787704 hasConcept C98274493 @default.
• W3040787704 hasConceptScore W3040787704C112705442 @default.
• W3040787704 hasConceptScore W3040787704C126322002 @default.
• W3040787704 hasConceptScore W3040787704C155574463 @default.
• W3040787704 hasConceptScore W3040787704C178790620 @default.
• W3040787704 hasConceptScore W3040787704C185592680 @default.
• W3040787704 hasConceptScore W3040787704C201399114 @default.
• W3040787704 hasConceptScore W3040787704C2779134260 @default.
• W3040787704 hasConceptScore W3040787704C2780035454 @default.
• W3040787704 hasConceptScore W3040787704C2780479503 @default.
• W3040787704 hasConceptScore W3040787704C55493867 @default.

• next