FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3040797002> ?p ?o ?g. }

• W3040797002 abstract "Objectives: to investigate the relationship of R1587K genotypes with cardiovascular (CV) risk, metabolic syndrome (MetS), lipid profile, paraoxonase-1 (PON1) activity, and anti-oxLDL titers. Methods: we performed a cross-sectional study in 57 northern Mexican adults with no reported diseases. The ABCA1 R1587K SNP was detected by real-time polymerase chain reaction (qPCR) using TaqMan allelic discrimination probes. We evaluated the relationship of R1587K with metabolic syndrome and clinical parameters including lipid profile, glucose and insulin, PON1 activity and concentration, anti-oxLDL antibodies, anthropometry and body-composition parameters, and the atherogenic index of plasma calculation. Results: our results show higher triglyceride levels in the RK + KK carriers as compared to RR carriers (p = 0.031). An association between the RK + KK genotype and the presence of MetS (OR = 4.566, 95% CI = 1.386-14.92, p = 0.010) and a tendency towards high CV risk (OR = 3.317, 95% CI = 0.910-8.611, p = 0.069) was observed in comparison to RR carriers; however, there were no differences in HDL-C levels, PON1 activity and concentration, and anti-oxLDL titers among the R1587K genotypes. Conclusions: in the northern Mexican population, the ABCA1 gene R1587K SNP is present and the RK + KK genotypes are associated with MetS and increased triglyceride concentrations; therefore, it could be a CV risk biomarker. Nevertheless there is a need for further confirmation in longitudinal studies.Objetivo: investigar la relación de los genotipos del SNP R1587K con el riesgo cardiovascular (CV), el síndrome metabólico (SM), el perfil de lípidos, la actividad de paraoxonasa 1 (PON1) y los anticuerpos contra las LDL oxidadas (anti-oxLDL). Métodos: se realizó un estudio transversal con 57 adultos del norte de México que reportaron no tener enfermedades diagnosticadas. El SNP R1587K del gen ABCA1 se detectó a través de PCR en tiempo real (qPCR) usando sondas TaqMan para discriminación alélica. Para evaluar la asociación del SNP R1587K con el SM y determinados parámetros clínicos se determinaron el perfil de lípidos, los niveles de glucosa e insulina, la actividad y concentración de PON1, los anticuerpos anti-oxLDL, los parámetros antropométricos y de composición corporal, y el cálculo del índice aterogénico en plasma. Resultados: los resultados mostraron mayores niveles de triglicéridos en los portadores del genotipo RR + KK que en los portadores de RR (p = 0,031). Se observó una asociación entre el genotipo RK + KK y la presencia de SM (OR = 4,566, IC 95% = 1,386-14,92, p = 0,010) y una tendencia hacia un mayor riesgo cardiovascular (OR = 3,317, IC 95% = 0,910-8,611, p = 0,069) al compararlos con los portadores de RR. No se encontraron diferencias en los niveles de HDL-C, la actividad y concentración de PON1 y los anti-oxLDL entre los genotipos R1587K. Conclusiones: el SNP R1587K del gen ABCA1 se encuentra presente en la población del norte de México y el genotipo RK + KK se asocia con el SM y concentraciones elevadas de triglicéridos, por lo que este SNP podría ser un biomarcador de riesgo cardiovascular. Sin embargo, se necesita confirmación a través de estudios longitudinales. ." @default.
• W3040797002 created "2020-07-16" @default.
• W3040797002 creator A5007279648 @default.
• W3040797002 creator A5011758095 @default.
• W3040797002 creator A5016730525 @default.
• W3040797002 creator A5034016883 @default.
• W3040797002 creator A5040460959 @default.
• W3040797002 creator A5043901851 @default.
• W3040797002 creator A5089341997 @default.
• W3040797002 date "2020-01-01" @default.
• W3040797002 modified "2023-09-27" @default.
• W3040797002 title "ABCA1 gene R1587K polymorphism could be associated with metabolic syndrome and increased plasma triglyceride concentration in adults from northern Mexico" @default.
• W3040797002 doi "https://doi.org/10.20960/nh.03087" @default.
• W3040797002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32686443" @default.
• W3040797002 hasPublicationYear "2020" @default.
• W3040797002 type Work @default.
• W3040797002 sameAs 3040797002 @default.
• W3040797002 citedByCount "0" @default.
• W3040797002 crossrefType "journal-article" @default.
• W3040797002 hasAuthorship W3040797002A5007279648 @default.
• W3040797002 hasAuthorship W3040797002A5011758095 @default.
• W3040797002 hasAuthorship W3040797002A5016730525 @default.
• W3040797002 hasAuthorship W3040797002A5034016883 @default.
• W3040797002 hasAuthorship W3040797002A5040460959 @default.
• W3040797002 hasAuthorship W3040797002A5043901851 @default.
• W3040797002 hasAuthorship W3040797002A5089341997 @default.
• W3040797002 hasBestOaLocation W30407970021 @default.
• W3040797002 hasConcept C104317684 @default.
• W3040797002 hasConcept C126322002 @default.
• W3040797002 hasConcept C134018914 @default.
• W3040797002 hasConcept C135763542 @default.
• W3040797002 hasConcept C139275648 @default.
• W3040797002 hasConcept C153209595 @default.
• W3040797002 hasConcept C2778163477 @default.
• W3040797002 hasConcept C2778270857 @default.
• W3040797002 hasConcept C2778913445 @default.
• W3040797002 hasConcept C2780578515 @default.
• W3040797002 hasConcept C2908647359 @default.
• W3040797002 hasConcept C37501387 @default.
• W3040797002 hasConcept C54355233 @default.
• W3040797002 hasConcept C555293320 @default.
• W3040797002 hasConcept C71924100 @default.
• W3040797002 hasConcept C86803240 @default.
• W3040797002 hasConcept C99454951 @default.
• W3040797002 hasConceptScore W3040797002C104317684 @default.
• W3040797002 hasConceptScore W3040797002C126322002 @default.
• W3040797002 hasConceptScore W3040797002C134018914 @default.
• W3040797002 hasConceptScore W3040797002C135763542 @default.
• W3040797002 hasConceptScore W3040797002C139275648 @default.
• W3040797002 hasConceptScore W3040797002C153209595 @default.
• W3040797002 hasConceptScore W3040797002C2778163477 @default.
• W3040797002 hasConceptScore W3040797002C2778270857 @default.
• W3040797002 hasConceptScore W3040797002C2778913445 @default.
• W3040797002 hasConceptScore W3040797002C2780578515 @default.
• W3040797002 hasConceptScore W3040797002C2908647359 @default.
• W3040797002 hasConceptScore W3040797002C37501387 @default.
• W3040797002 hasConceptScore W3040797002C54355233 @default.
• W3040797002 hasConceptScore W3040797002C555293320 @default.
• W3040797002 hasConceptScore W3040797002C71924100 @default.
• W3040797002 hasConceptScore W3040797002C86803240 @default.
• W3040797002 hasConceptScore W3040797002C99454951 @default.
• W3040797002 hasLocation W30407970021 @default.
• W3040797002 hasLocation W30407970022 @default.
• W3040797002 hasOpenAccess W3040797002 @default.
• W3040797002 hasPrimaryLocation W30407970021 @default.
• W3040797002 hasRelatedWork W1969808273 @default.
• W3040797002 hasRelatedWork W1993873099 @default.
• W3040797002 hasRelatedWork W2013998010 @default.
• W3040797002 hasRelatedWork W2023333646 @default.
• W3040797002 hasRelatedWork W2028937980 @default.
• W3040797002 hasRelatedWork W2035484352 @default.
• W3040797002 hasRelatedWork W2151578115 @default.
• W3040797002 hasRelatedWork W2162912823 @default.
• W3040797002 hasRelatedWork W2350174576 @default.
• W3040797002 hasRelatedWork W2418447797 @default.
• W3040797002 isParatext "false" @default.
• W3040797002 isRetracted "false" @default.
• W3040797002 magId "3040797002" @default.
• W3040797002 workType "article" @default.