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- W3040803525 endingPage "4241" @default.
- W3040803525 startingPage "4232" @default.
- W3040803525 abstract "Computational approaches have been developed to prioritize candidate genes in disease gene identification. They are based on different pieces of evidences associating each gene with the given disease. In this study, 648 genes underlying genodermatoses have been compared to 1808 genes involved in other genetic diseases using a bioinformatic approach. These genes were studied at the structural, evolutionary and functional levels. Results show that genes underlying genodermatoses present longer CDS and have more exons. Significant differences were observed in nucleotide motif and amino-acid compositions. Evolutionary conservation analysis revealed that genodermatoses genes have less paralogs, more orthologs in Mouse and Dog and are less conserved. Functional analysis revealed that genodermatosis genes seem to be involved in immune system and skin layers. The Bayesian network model returned a rate of good classification of around 80%. This computational approach could help investigators working in the field of dermatology by prioritizing positional candidate genes for mutation screening." @default.
- W3040803525 created "2020-07-16" @default.
- W3040803525 creator A5010500259 @default.
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- W3040803525 creator A5027889523 @default.
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- W3040803525 creator A5059332002 @default.
- W3040803525 creator A5062052623 @default.
- W3040803525 creator A5081356743 @default.
- W3040803525 date "2020-11-01" @default.
- W3040803525 modified "2023-09-30" @default.
- W3040803525 title "The morbid cutaneous anatomy of the human genome revealed by a bioinformatic approach" @default.
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