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• W3040804601 abstract "PURPOSE: An accelerated ageing process places those with type 2 diabetes mellitus (T2DM) at risk of physical functional impairments at a younger age. Although the importance of moderate-to-vigorous physical activity (MVPA) is acknowledged, emerging research suggests that sedentary time may be also be important. Therefore, the aim was to examine cross-sectional associations between device-assessed sedentary time and markers of physical function in a population with T2DM and to determine whether associations were modified by the recommended levels of MVPA. METHODS: Participants with T2DM (>6months), aged 18-75 years were recruited as part of an ongoing, cross-sectional study (CODEC) conducted in the Midlands, UK. Participants were asked to wear an accelerometer (GENEActiv, ActivInsights Ltd, Kimbolton, UK) on their non-dominant wrist for 7 days to quantify habitual levels of sedentary time and MVPA. Generalised linear models examined the associations between sedentary time, the short physical performance battery (SPPB), the sit-to-stand 60 second test (STS60) and 4 metre timed walk. Interaction terms determined whether results were consistent across MVPA categories (active [>150min/wk of MVPA] vs. inactive [<150min/wk of MVPA]) RESULTS: 621 participants had valid accelerometer and physical function data (age 63.6±8.4 years, 34.5% female, BMI=31.0±5.0kg/m2). Following adjustment for various covariates, including age, sex, ethnicity, medication and MVPA, sedentary time was detrimentally associated with SPPB score, STS60 reps and walk time. When results were stratified by MVPA (active (24.5%) vs. inactive (75.5%)), each 60 minutes of sedentary time was associated with a 0.3 lower SPPB score (p=0.020), 1.4 fewer STS60 reps (p=0.016) and 0.2s longer walk time (p=0.043) in the inactive group only. No significant associations were found in the active group. CONCLUSION: Sedentary time is adversely associated with markers of physical function, but associations were only present in those individuals who do not meet current physical activity recommendations for health. Along with promoting MVPA, future therapeutic interventions that focus on reducing sedentary time in those with T2DM and impaired physical function may be warranted in inactive individuals. Supported by NIHR Leicester BRC." @default.
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• W3040804601 date "2020-07-01" @default.
• W3040804601 modified "2023-09-26" @default.
• W3040804601 title "Sedentary Time And Markers Of Physical Function In Those With Established Type 2 Diabetes" @default.
• W3040804601 doi "https://doi.org/10.1249/01.mss.0000675252.66191.98" @default.
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