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• W3040807515 abstract "PURPOSE: To characterize the changes of different fragments of the strong positive inotropic peptide Apelin (AP) upon extreme physical stress in Hungarian handball players. The 77-amino acid preproapelin is cleaved to shorter active peptides, such as AP-36 and AP-13. However, these Apelin receptor agonists may differ in biological efficacy, with the shorter fragments being more potent. METHODS: We investigated the response of male athletes (n=54; age=24±2) to extreme physical (vita maxima treadmill test) stress. Cardiovascular, metabolic and respiratory parameters were monitored. All parameters were measured at baseline, at maximal stress situation and 30 minutes in the restitution phase. Circulating peptide (AP-13, AP-36, NT-proBNP) levels were measured by ELISA. RESULTS: AP-13 levels increased significantly at the peak of the treadmill test (167±71.5 pg/ml), compared to baseline values (144±72.4 pg/ml; p<0.05). After 30 minutes of recovery, AP-13 levels decreased significantly (137±65.7 pg/ml; p<0.001) returning to the baseline levels (p=NS). AP-36 showed a more robust increase in response to the maximal intensity treadmill test (80.7±61.4 pg/ml vs. 159±81.8 pg/ml; p<0.001), which decreased below the control levels after 30 minutes of restitution (52.4±23.2 pg/ml; p<0.001). NT-proBNP levels remained unchanged in all settings. Importantly, baseline and peak AP-13 levels showed a negative correlation with AP-36 response to the treadmill test (r=-0.400, p<0.05; r=-0.416, p<0.05; respectively). The change in AP-13 level upon extreme physical stimulation correlated with the maximal MET (r=0.374, p<0.05) and the relative VO2max (r=0.340, p<0.05). Our subjects showed differential AP response: 62% of the individuals showed elevated whereas 38% lower AP-13 levels after the treadmill test. AP-36 increased in 85% and decreased in 15% of the athletes at peak intensity. CONCLUSION: Collectively, our data show that both Apelin fragments change significantly after a vita maxima treadmill test, suggesting that Apelin as an endogenous positive inotropic peptide may contribute to the stress adaption of the heart. Athletes having higher baseline and peak AP-13 plasma concentrations had a lower AP-36 response, suggesting the existence of a previously unknown interplay between the distinct fragments." @default.
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• W3040807515 date "2020-07-01" @default.
• W3040807515 modified "2023-09-26" @default.
• W3040807515 title "Differential Apelin Responses To Physical Stress In Elite Hungarian Athletes" @default.
• W3040807515 doi "https://doi.org/10.1249/01.mss.0000682912.40768.20" @default.
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