FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3040821620> ?p ?o ?g. }

• W3040821620 endingPage "1016" @default.
• W3040821620 startingPage "1007" @default.
• W3040821620 abstract "Osteoarthritis is increasingly viewed as a heterogeneous disease with multiple phenotypic subgroups. Obesity enhances joint degeneration in mouse models of posttraumatic osteoarthritis (PTOA). Most models of PTOA involve damage to surrounding tissues caused by surgery/fracture; it is unclear if obesity enhances cartilage degeneration in the absence of surgery/fracture. We used a nonsurgical animal model of load-induced PTOA to determine the effect of obesity on cartilage degeneration 2 weeks after loading. Cartilage degeneration was caused by a single bout of cyclic tibial loading at either a high or moderate load magnitude in adult male mice with severe obesity (C57Bl6/J + high-fat diet), mild obesity (toll-like receptor 5 deficient mouse [TLR5KO]), or normal adiposity (C57Bl6/J mice + normal diet and TLR5KO mice in which obesity was prevented by manipulation of the gut microbiome). Two weeks after loading, cartilage degeneration occurred in limbs loaded at a high magnitude, as determined by OARSI scores (P < .001). However, the severity of cartilage damage did not differ among groups. Osteophyte width and synovitis of loaded limbs did not differ among groups. Furthermore, obesity did not enhance cartilage damage in limbs evaluated 6 weeks after loading. Constituents of the gut microbiota differed among groups. Our findings suggest that, in the absence of surgery/fracture, obesity may not influence cartilage loss after a single mechanical insult, suggesting that either damage to surrounding tissues or repeated mechanical insult is necessary for obesity to influence cartilage degeneration. These findings further illustrate heterogeneity in PTOA phenotypes and complex interactions between mechanical/metabolic factors in cartilage loss." @default.
• W3040821620 created "2020-07-16" @default.
• W3040821620 creator A5003440200 @default.
• W3040821620 creator A5005763012 @default.
• W3040821620 creator A5017381763 @default.
• W3040821620 creator A5022048355 @default.
• W3040821620 creator A5032154672 @default.
• W3040821620 creator A5034787812 @default.
• W3040821620 creator A5045158229 @default.
• W3040821620 creator A5047922767 @default.
• W3040821620 creator A5050217419 @default.
• W3040821620 creator A5051051769 @default.
• W3040821620 creator A5056567815 @default.
• W3040821620 creator A5056696283 @default.
• W3040821620 creator A5064477655 @default.
• W3040821620 creator A5080984126 @default.
• W3040821620 date "2020-07-17" @default.
• W3040821620 modified "2023-10-06" @default.
• W3040821620 title "Obesity and load‐induced posttraumatic osteoarthritis in the absence of fracture or surgical trauma" @default.
• W3040821620 cites W11753821 @default.
• W3040821620 cites W1523266228 @default.
• W3040821620 cites W1533739166 @default.
• W3040821620 cites W1793532565 @default.
• W3040821620 cites W1848620583 @default.
• W3040821620 cites W1967491164 @default.
• W3040821620 cites W1979683246 @default.
• W3040821620 cites W1990895739 @default.
• W3040821620 cites W2022991367 @default.
• W3040821620 cites W2041136224 @default.
• W3040821620 cites W2041676787 @default.
• W3040821620 cites W2045851923 @default.
• W3040821620 cites W2058435889 @default.
• W3040821620 cites W2062652371 @default.
• W3040821620 cites W2066749771 @default.
• W3040821620 cites W2078378773 @default.
• W3040821620 cites W2079010022 @default.
• W3040821620 cites W2085788584 @default.
• W3040821620 cites W2099647314 @default.
• W3040821620 cites W2099729330 @default.
• W3040821620 cites W2114381345 @default.
• W3040821620 cites W2116041602 @default.
• W3040821620 cites W2127174807 @default.
• W3040821620 cites W2152089866 @default.
• W3040821620 cites W2153064758 @default.
• W3040821620 cites W2167037356 @default.
• W3040821620 cites W2171245019 @default.
• W3040821620 cites W2172297599 @default.
• W3040821620 cites W2189948118 @default.
• W3040821620 cites W2280239319 @default.
• W3040821620 cites W2398417419 @default.
• W3040821620 cites W2430892484 @default.
• W3040821620 cites W2559802456 @default.
• W3040821620 cites W2594496417 @default.
• W3040821620 cites W2604174049 @default.
• W3040821620 cites W2606236360 @default.
• W3040821620 cites W2734059271 @default.
• W3040821620 cites W2741105523 @default.
• W3040821620 cites W2774210970 @default.
• W3040821620 cites W2793435470 @default.
• W3040821620 cites W2799337008 @default.
• W3040821620 cites W2807060002 @default.
• W3040821620 cites W2890313526 @default.
• W3040821620 cites W2913354073 @default.
• W3040821620 cites W2949027991 @default.
• W3040821620 cites W2955909334 @default.
• W3040821620 cites W2972322444 @default.
• W3040821620 cites W2989334349 @default.
• W3040821620 cites W4232024554 @default.
• W3040821620 cites W92404310 @default.
• W3040821620 doi "https://doi.org/10.1002/jor.24799" @default.
• W3040821620 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7855296" @default.
• W3040821620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32658313" @default.
• W3040821620 hasPublicationYear "2020" @default.
• W3040821620 type Work @default.
• W3040821620 sameAs 3040821620 @default.
• W3040821620 citedByCount "4" @default.
• W3040821620 countsByYear W30408216202021 @default.
• W3040821620 countsByYear W30408216202022 @default.
• W3040821620 countsByYear W30408216202023 @default.
• W3040821620 crossrefType "journal-article" @default.
• W3040821620 hasAuthorship W3040821620A5003440200 @default.
• W3040821620 hasAuthorship W3040821620A5005763012 @default.
• W3040821620 hasAuthorship W3040821620A5017381763 @default.
• W3040821620 hasAuthorship W3040821620A5022048355 @default.
• W3040821620 hasAuthorship W3040821620A5032154672 @default.
• W3040821620 hasAuthorship W3040821620A5034787812 @default.
• W3040821620 hasAuthorship W3040821620A5045158229 @default.
• W3040821620 hasAuthorship W3040821620A5047922767 @default.
• W3040821620 hasAuthorship W3040821620A5050217419 @default.
• W3040821620 hasAuthorship W3040821620A5051051769 @default.
• W3040821620 hasAuthorship W3040821620A5056567815 @default.
• W3040821620 hasAuthorship W3040821620A5056696283 @default.
• W3040821620 hasAuthorship W3040821620A5064477655 @default.
• W3040821620 hasAuthorship W3040821620A5080984126 @default.
• W3040821620 hasBestOaLocation W30408216202 @default.
• W3040821620 hasConcept C105702510 @default.
• W3040821620 hasConcept C126322002 @default.
• W3040821620 hasConcept C141071460 @default.

• next