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- W3040831880 abstract "The capabilities for biosynthesis of long-chain (≥C20) polyunsaturated fatty acid (LC-PUFA) of farmed fish have beenextensively studied in order to determine qualitative requirements for dietary essential fatty acids and to ensure high levelsof omega-3 LC-PUFA in the farmed products for human consumption. Although LC-PUFA biosynthesis comprises multiplesteps catalyzed by several enzymes, rate-limiting reactions in the pathways are controlled by fatty acid desaturases (Fads),enzymes introducing new double bonds into fatty acyl chains. The repertoire of Fads-encoding genes varies amongvertebrates. Mammals have two FADS with known roles in the LC-PUFA biosynthetic pathways, namely FADS1 with Δ5desaturase activity and FADS2 with Δ6 activity. Interestingly, teleosts, the fish group which most farmed species belong to,appear to have lost fads1 during evolution and therefore Fads2 is the sole enzyme able to account for the desaturationreactions in the LC-PUFA pathway in teleosts. Unlike mammals though, functions of teleost Fads2 have diversifiedremarkably as a result of species-specific evolutionary history and environmental factors including habitat (marine vsfreshwater), trophic level and ecology. This paper reviews the recent progress made on molecular aspects underlying thefunctional diversity of Fads2 characterized so far from finfish species. Specifically, we discuss the potential implicationsthat Fads2 functions have for the ability of fish species to efficiently utilize dietary fatty acids when fed on vegetable oilbasedfeeds. In addition, current developing technologies including genetic approaches (e.g. transgenesis) to improve theLC-PUFA biosynthetic capability of fish are discussed." @default.
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- W3040831880 date "2017-11-30" @default.
- W3040831880 modified "2023-10-04" @default.
- W3040831880 title "Diversification of Fads2 in Finfish Species: Implications for Aquaculture" @default.
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