FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3040840250> ?p ?o ?g. }

• W3040840250 endingPage "919" @default.
• W3040840250 startingPage "919" @default.
• W3040840250 abstract "PURPOSE: Collagen is the most abundant protein in the body and functions to provide the mechanical strength of connective tissues. In muscle, collagen fibrils function both to hold muscle fibers together and transmit force laterally between fibers. With aging, force transmission is reduced; however, how changes to specific collagen isoforms or the matrix orientation contribute to force loss is currently unclear. The current study was designed to compare lateral force transmission in the gastrocnemius muscle of young and old people with changes in specific collagen proteins and the orientation of the matrix. METHODS: The calf strength of 12 subjects, 5 between 18 and 30 years old and 7 over the age of 65, was measured within an MRI. Images were taken to determine lateral force transmission. Following strength testing, biopsies were obtained under local anesthetic from the gastrocnemius muscle. Biopsies were pinned to cork at resting length and frozen in isopentane cooled in liquid nitrogen. Cross-sections were taken to determine collagens I, III, IV, and V content, whereas longitudinal sections were stained with picrosirius red to determine matrix orientation. The collagen IV image was also used to determine muscle fiber cross-sectional area (CSA). RESULTS: Collagen I and V were evenly dispersed throughout the cross-sections, whereas Collagen IV and VI were densest around individual muscle fibers. Collagen IV content was similar in young and old. As expected, fiber CSA tended (p = 0.1) to decrease in the old subjects. Picrosirius red staining showed that the collagen matrix is oriented at a 22.3±3.1% angle to the fibers in young and 30.2±8.7% in old subjects. CONCLUSIONS: Preliminary data suggests that, in the old, fiber CSA decreases and the extracellular matrix becomes less aligned. By establishing the role of specific collagen proteins during aging, we hope to better understand the relationship between the extracellular matrix and force transmission in muscle and how this relationship is modified by age." @default.
• W3040840250 created "2020-07-16" @default.
• W3040840250 creator A5010694564 @default.
• W3040840250 creator A5016654292 @default.
• W3040840250 creator A5027347289 @default.
• W3040840250 creator A5030932581 @default.
• W3040840250 creator A5035958290 @default.
• W3040840250 creator A5041501226 @default.
• W3040840250 creator A5053683861 @default.
• W3040840250 creator A5067681173 @default.
• W3040840250 date "2020-07-01" @default.
• W3040840250 modified "2023-09-27" @default.
• W3040840250 title "The Role Of Collagen Composition And Orientation In Lateral Force Transmission With Aging" @default.
• W3040840250 doi "https://doi.org/10.1249/01.mss.0000685524.07755.0e" @default.
• W3040840250 hasPublicationYear "2020" @default.
• W3040840250 type Work @default.
• W3040840250 sameAs 3040840250 @default.
• W3040840250 citedByCount "0" @default.
• W3040840250 crossrefType "journal-article" @default.
• W3040840250 hasAuthorship W3040840250A5010694564 @default.
• W3040840250 hasAuthorship W3040840250A5016654292 @default.
• W3040840250 hasAuthorship W3040840250A5027347289 @default.
• W3040840250 hasAuthorship W3040840250A5030932581 @default.
• W3040840250 hasAuthorship W3040840250A5035958290 @default.
• W3040840250 hasAuthorship W3040840250A5041501226 @default.
• W3040840250 hasAuthorship W3040840250A5053683861 @default.
• W3040840250 hasAuthorship W3040840250A5067681173 @default.
• W3040840250 hasBestOaLocation W30408402501 @default.
• W3040840250 hasConcept C105702510 @default.
• W3040840250 hasConcept C106487976 @default.
• W3040840250 hasConcept C12554922 @default.
• W3040840250 hasConcept C142724271 @default.
• W3040840250 hasConcept C178790620 @default.
• W3040840250 hasConcept C185592680 @default.
• W3040840250 hasConcept C189165786 @default.
• W3040840250 hasConcept C27523624 @default.
• W3040840250 hasConcept C2993866533 @default.
• W3040840250 hasConcept C3019161014 @default.
• W3040840250 hasConcept C43617362 @default.
• W3040840250 hasConcept C518705261 @default.
• W3040840250 hasConcept C519885992 @default.
• W3040840250 hasConcept C55493867 @default.
• W3040840250 hasConcept C71924100 @default.
• W3040840250 hasConcept C86803240 @default.
• W3040840250 hasConceptScore W3040840250C105702510 @default.
• W3040840250 hasConceptScore W3040840250C106487976 @default.
• W3040840250 hasConceptScore W3040840250C12554922 @default.
• W3040840250 hasConceptScore W3040840250C142724271 @default.
• W3040840250 hasConceptScore W3040840250C178790620 @default.
• W3040840250 hasConceptScore W3040840250C185592680 @default.
• W3040840250 hasConceptScore W3040840250C189165786 @default.
• W3040840250 hasConceptScore W3040840250C27523624 @default.
• W3040840250 hasConceptScore W3040840250C2993866533 @default.
• W3040840250 hasConceptScore W3040840250C3019161014 @default.
• W3040840250 hasConceptScore W3040840250C43617362 @default.
• W3040840250 hasConceptScore W3040840250C518705261 @default.
• W3040840250 hasConceptScore W3040840250C519885992 @default.
• W3040840250 hasConceptScore W3040840250C55493867 @default.
• W3040840250 hasConceptScore W3040840250C71924100 @default.
• W3040840250 hasConceptScore W3040840250C86803240 @default.
• W3040840250 hasIssue "7S" @default.
• W3040840250 hasLocation W30408402501 @default.
• W3040840250 hasLocation W30408402502 @default.
• W3040840250 hasOpenAccess W3040840250 @default.
• W3040840250 hasPrimaryLocation W30408402501 @default.
• W3040840250 hasRelatedWork W1994547846 @default.
• W3040840250 hasRelatedWork W2039053583 @default.
• W3040840250 hasRelatedWork W2062357585 @default.
• W3040840250 hasRelatedWork W2106734809 @default.
• W3040840250 hasRelatedWork W2109518128 @default.
• W3040840250 hasRelatedWork W2113447361 @default.
• W3040840250 hasRelatedWork W2148671608 @default.
• W3040840250 hasRelatedWork W2181367652 @default.
• W3040840250 hasRelatedWork W3004947913 @default.
• W3040840250 hasRelatedWork W4311897059 @default.
• W3040840250 hasVolume "52" @default.
• W3040840250 isParatext "false" @default.
• W3040840250 isRetracted "false" @default.
• W3040840250 magId "3040840250" @default.
• W3040840250 workType "article" @default.