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- W3040852275 endingPage "387" @default.
- W3040852275 startingPage "375" @default.
- W3040852275 abstract "The first compartmental computer models of brain neurons using the Rall method predicted novel and unexpected dendrodendritic interactions between mitral and granule cells in the olfactory bulb. We review the models from a 50-year perspective on the work that has challenged, supported, and extended the original proposal that these interactions mediate both lateral inhibition and oscillatory activity, essential steps in the neural basis of olfactory processing and perception. We highlight strategies behind the neurophysiological experiments and the Rall methods that enhance the ability of detailed compartmental modeling to give counterintuitive predictions that lead to deeper insights into neural organization at the synaptic and circuit level. The application of these methods to mechanisms of neurogenesis and plasticity are exciting challenges for the future." @default.
- W3040852275 created "2020-07-16" @default.
- W3040852275 creator A5001447073 @default.
- W3040852275 creator A5003469942 @default.
- W3040852275 creator A5027748067 @default.
- W3040852275 creator A5052931874 @default.
- W3040852275 creator A5084672179 @default.
- W3040852275 date "2020-08-01" @default.
- W3040852275 modified "2023-10-16" @default.
- W3040852275 title "Predicting brain organization with a computational model: 50-year perspective on lateral inhibition and oscillatory gating by dendrodendritic synapses" @default.
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- W3040852275 doi "https://doi.org/10.1152/jn.00175.2020" @default.