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- W3040856103 abstract "Chronic obstructive pulmonary disease (COPD) is a chronic respiratory system disease with high mortality rates. COPD has a tendency of family aggregation, and is often caused by the accumulation of multiple genes interaction and environmental factors. Currently, N6-methyladenosine (m6A) has been found to affect mRNA processing in multiple stages in some cancers related studies. However, the related studies about the modification of m6A by regulatory factors are related to cell death and cell proliferation, leading to COPD disease were not addressed. Therefore, in this study, we aimed to explore the potential relationships among m6A RNA methylation regulators and COPD based on the COPD expression profiles. We constructed m6A regulators related sub-networks and network motifs using STRING database and performed Gene Set Variation Analysis (GSVA) for each sub-network. Our results found that a high correlation among writers, erasers and readers. Specially, the obvious difference was observed between COPD patients from normal controls in activation of YTHDF2-related network. This study may provide new perspective for explore pathology of the occurrence and development of COPD." @default.
- W3040856103 created "2020-07-16" @default.
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- W3040856103 date "2020-05-22" @default.
- W3040856103 modified "2023-09-23" @default.
- W3040856103 title "An Exploration of Possible Association between m6A Methylation Regulators and Chronic Obstructive Pulmonary Disease by a Bioinformatics Analysis" @default.
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- W3040856103 doi "https://doi.org/10.1145/3405758.3405766" @default.
- W3040856103 hasPublicationYear "2020" @default.
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