FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3040858811> ?p ?o ?g. }

• W3040858811 abstract "ABSTRACT Preeclampsia is a pregnancy specific syndrome characterized by hypertension and proteinuria after 20 weeks of gestation. To reveal the relationship between lipids and preeclampsia, we conduct lipidomic profiling of maternal serums of 44 severe preeclamptic and 20 healthy pregnancies from a multi-ethnic cohort in Hawaii. Correlation network analysis shows that oxidized phospholipids (OxPLs) have increased inter-correlations and connections in preeclampsia, while other lipids, including triacylglycerols (TAGs), have reduced network correlations and connections. Thirty-one lipid species from various lipid classes demonstrate predominantly reductions and causal relationships with preeclampsia. They include phosphatidylglycerol (PG), TAG, diacylglycerol (DAG), phosphatidylcholine (PC), cholesterol esters (CE), phosphatidylethanolamine (PE), sphingomyelin (SM), ceramides (Cer-NS), hexosyl ceramides (HexCer-NS), lysophosphatidylcholine (LPC), lysophosphatidylethanolamine (LPE), and free fatty acid (FFA). Many of these lipids are also selected as important features by a linear discriminant analysis (LDA) classifier with high predictive accuracy (F-1 statistic 0.941 and balanced accuracy 0.88), indicating their potential to serve as biomarkers for severe preeclampsia. Our study supports the hypothesis of a phospholipid (PL) centered, dysregulated lipidomic metabolic atlas. That is, severe preeclampsia may be originated from hypoxia, which induces the accumulation of OxPLs through oxidative stress whereas reduces many other lipids (eg. reduced PCs, TAGs and ceramides). These molecular changes coherently lead to dysregulated biological functions, such as insulin signaling and inflammation/infections. Moreover, the lipid changes may also be responsible for the comorbidity between preeclampsia and gestational diabetes, a clinically known risk factor for preeclampsia." @default.
• W3040858811 created "2020-07-16" @default.
• W3040858811 creator A5005523854 @default.
• W3040858811 creator A5018073672 @default.
• W3040858811 creator A5022805964 @default.
• W3040858811 creator A5026175248 @default.
• W3040858811 creator A5027351945 @default.
• W3040858811 creator A5060828456 @default.
• W3040858811 creator A5062832709 @default.
• W3040858811 creator A5065859286 @default.
• W3040858811 date "2020-07-08" @default.
• W3040858811 modified "2023-10-16" @default.
• W3040858811 title "Maternal blood lipidomics analyses link critical metabolic pathways associated with severe preeclampsia" @default.
• W3040858811 cites W126188432 @default.
• W3040858811 cites W1505812337 @default.
• W3040858811 cites W1880136169 @default.
• W3040858811 cites W1975195151 @default.
• W3040858811 cites W1985781493 @default.
• W3040858811 cites W1991006612 @default.
• W3040858811 cites W1995608123 @default.
• W3040858811 cites W2025144170 @default.
• W3040858811 cites W2032983932 @default.
• W3040858811 cites W2037833102 @default.
• W3040858811 cites W2042840742 @default.
• W3040858811 cites W2055325448 @default.
• W3040858811 cites W2060705109 @default.
• W3040858811 cites W2087354802 @default.
• W3040858811 cites W2109047597 @default.
• W3040858811 cites W2110571546 @default.
• W3040858811 cites W2112295687 @default.
• W3040858811 cites W2123627435 @default.
• W3040858811 cites W2130576136 @default.
• W3040858811 cites W2144480372 @default.
• W3040858811 cites W2146512944 @default.
• W3040858811 cites W2147686004 @default.
• W3040858811 cites W2151180898 @default.
• W3040858811 cites W2152311269 @default.
• W3040858811 cites W2156334030 @default.
• W3040858811 cites W2167884838 @default.
• W3040858811 cites W2169293642 @default.
• W3040858811 cites W2275280366 @default.
• W3040858811 cites W2325670199 @default.
• W3040858811 cites W2486975460 @default.
• W3040858811 cites W2520592021 @default.
• W3040858811 cites W2524642465 @default.
• W3040858811 cites W2604951002 @default.
• W3040858811 cites W2617096263 @default.
• W3040858811 cites W2751026802 @default.
• W3040858811 cites W2767582147 @default.
• W3040858811 cites W2889797751 @default.
• W3040858811 cites W2912841627 @default.
• W3040858811 cites W2949819623 @default.
• W3040858811 cites W2976327316 @default.
• W3040858811 cites W3003112162 @default.
• W3040858811 cites W4231726431 @default.
• W3040858811 doi "https://doi.org/10.1101/2020.07.05.20145292" @default.
• W3040858811 hasPublicationYear "2020" @default.
• W3040858811 type Work @default.
• W3040858811 sameAs 3040858811 @default.
• W3040858811 citedByCount "0" @default.
• W3040858811 crossrefType "posted-content" @default.
• W3040858811 hasAuthorship W3040858811A5005523854 @default.
• W3040858811 hasAuthorship W3040858811A5018073672 @default.
• W3040858811 hasAuthorship W3040858811A5022805964 @default.
• W3040858811 hasAuthorship W3040858811A5026175248 @default.
• W3040858811 hasAuthorship W3040858811A5027351945 @default.
• W3040858811 hasAuthorship W3040858811A5060828456 @default.
• W3040858811 hasAuthorship W3040858811A5062832709 @default.
• W3040858811 hasAuthorship W3040858811A5065859286 @default.
• W3040858811 hasBestOaLocation W30408588111 @default.
• W3040858811 hasConcept C126322002 @default.
• W3040858811 hasConcept C134018914 @default.
• W3040858811 hasConcept C2776330855 @default.
• W3040858811 hasConcept C2777218350 @default.
• W3040858811 hasConcept C2778096610 @default.
• W3040858811 hasConcept C2778163477 @default.
• W3040858811 hasConcept C2778918659 @default.
• W3040858811 hasConcept C2779234561 @default.
• W3040858811 hasConcept C2780241833 @default.
• W3040858811 hasConcept C2781112429 @default.
• W3040858811 hasConcept C41625074 @default.
• W3040858811 hasConcept C54355233 @default.
• W3040858811 hasConcept C55493867 @default.
• W3040858811 hasConcept C555293320 @default.
• W3040858811 hasConcept C58017582 @default.
• W3040858811 hasConcept C60644358 @default.
• W3040858811 hasConcept C61322309 @default.
• W3040858811 hasConcept C71924100 @default.
• W3040858811 hasConcept C86803240 @default.
• W3040858811 hasConceptScore W3040858811C126322002 @default.
• W3040858811 hasConceptScore W3040858811C134018914 @default.
• W3040858811 hasConceptScore W3040858811C2776330855 @default.
• W3040858811 hasConceptScore W3040858811C2777218350 @default.
• W3040858811 hasConceptScore W3040858811C2778096610 @default.
• W3040858811 hasConceptScore W3040858811C2778163477 @default.
• W3040858811 hasConceptScore W3040858811C2778918659 @default.
• W3040858811 hasConceptScore W3040858811C2779234561 @default.
• W3040858811 hasConceptScore W3040858811C2780241833 @default.
• W3040858811 hasConceptScore W3040858811C2781112429 @default.
• W3040858811 hasConceptScore W3040858811C41625074 @default.

• next