Matches in SemOpenAlex for { <https://semopenalex.org/work/W3040872208> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W3040872208 abstract "Gleason score (GS) is a powerful prognostic factor in prostate cancer (PCa). A GS-7 tumor typically has the primary Gleason (architectural) pattern and secondary prevalent one being graded with 3 and 4 (or 4 and 3), respectively. Due to the well-known intratumoral multifocal occurrence of different patterns, a biological sample from a GS-7 tumor used in a molecular experiment will be uncertain regarding the actually represented pattern if no special attention is given to specimen preparation. In this study, by an integrative analysis of several published gene expression datasets, one of which is the profiling of the paired GP-3 (Gleason pattern 3) and GP-4 (Gleason pattern 4) specimens of 13 GS-7 tumors, we demonstrate that such an uncertainty can be frequently observed in the published data. More specifically, our results suggest that the GS-7 specimens used to generate the frequently-cited The Cancer Genome Atlas (TCGA) data and the Gene Expression Omnibus (GEO) dataset GSE21032 which largely are individual GP-3 or GP-4 specimens rather than the “intermediate” specimens of GP-3 and GP-4. This indicates a pitfall in the existing molecular research of prostate tumors relevant to GS and in GS-related molecular biomarker identification using the previously documented data." @default.
- W3040872208 created "2020-07-16" @default.
- W3040872208 creator A5007535547 @default.
- W3040872208 creator A5016038041 @default.
- W3040872208 creator A5060178337 @default.
- W3040872208 date "2020-09-16" @default.
- W3040872208 modified "2023-09-25" @default.
- W3040872208 title "Gene expression analysis reveals a pitfall in the molecular research of prostate tumors relevant to Gleason score" @default.
- W3040872208 cites W1563088657 @default.
- W3040872208 cites W1968629884 @default.
- W3040872208 cites W1996570931 @default.
- W3040872208 cites W1998343146 @default.
- W3040872208 cites W1999687329 @default.
- W3040872208 cites W2001730711 @default.
- W3040872208 cites W2036610808 @default.
- W3040872208 cites W2066226019 @default.
- W3040872208 cites W2071428121 @default.
- W3040872208 cites W2078451086 @default.
- W3040872208 cites W2088076795 @default.
- W3040872208 cites W2107633226 @default.
- W3040872208 cites W2122769082 @default.
- W3040872208 cites W2130387435 @default.
- W3040872208 cites W2149218801 @default.
- W3040872208 cites W2158217645 @default.
- W3040872208 cites W2161112598 @default.
- W3040872208 cites W2580794436 @default.
- W3040872208 doi "https://doi.org/10.1142/s0219720020500328" @default.
- W3040872208 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8627177" @default.
- W3040872208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32938283" @default.
- W3040872208 hasPublicationYear "2020" @default.
- W3040872208 type Work @default.
- W3040872208 sameAs 3040872208 @default.
- W3040872208 citedByCount "0" @default.
- W3040872208 crossrefType "journal-article" @default.
- W3040872208 hasAuthorship W3040872208A5007535547 @default.
- W3040872208 hasAuthorship W3040872208A5016038041 @default.
- W3040872208 hasAuthorship W3040872208A5060178337 @default.
- W3040872208 hasBestOaLocation W30408722082 @default.
- W3040872208 hasConcept C104317684 @default.
- W3040872208 hasConcept C121608353 @default.
- W3040872208 hasConcept C124535831 @default.
- W3040872208 hasConcept C142724271 @default.
- W3040872208 hasConcept C143998085 @default.
- W3040872208 hasConcept C150194340 @default.
- W3040872208 hasConcept C18431079 @default.
- W3040872208 hasConcept C2776235491 @default.
- W3040872208 hasConcept C2780192828 @default.
- W3040872208 hasConcept C2781197716 @default.
- W3040872208 hasConcept C3019646584 @default.
- W3040872208 hasConcept C46111723 @default.
- W3040872208 hasConcept C502942594 @default.
- W3040872208 hasConcept C54355233 @default.
- W3040872208 hasConcept C70721500 @default.
- W3040872208 hasConcept C71924100 @default.
- W3040872208 hasConcept C86803240 @default.
- W3040872208 hasConceptScore W3040872208C104317684 @default.
- W3040872208 hasConceptScore W3040872208C121608353 @default.
- W3040872208 hasConceptScore W3040872208C124535831 @default.
- W3040872208 hasConceptScore W3040872208C142724271 @default.
- W3040872208 hasConceptScore W3040872208C143998085 @default.
- W3040872208 hasConceptScore W3040872208C150194340 @default.
- W3040872208 hasConceptScore W3040872208C18431079 @default.
- W3040872208 hasConceptScore W3040872208C2776235491 @default.
- W3040872208 hasConceptScore W3040872208C2780192828 @default.
- W3040872208 hasConceptScore W3040872208C2781197716 @default.
- W3040872208 hasConceptScore W3040872208C3019646584 @default.
- W3040872208 hasConceptScore W3040872208C46111723 @default.
- W3040872208 hasConceptScore W3040872208C502942594 @default.
- W3040872208 hasConceptScore W3040872208C54355233 @default.
- W3040872208 hasConceptScore W3040872208C70721500 @default.
- W3040872208 hasConceptScore W3040872208C71924100 @default.
- W3040872208 hasConceptScore W3040872208C86803240 @default.
- W3040872208 hasFunder F4320332161 @default.
- W3040872208 hasLocation W30408722081 @default.
- W3040872208 hasLocation W30408722082 @default.
- W3040872208 hasLocation W30408722083 @default.
- W3040872208 hasOpenAccess W3040872208 @default.
- W3040872208 hasPrimaryLocation W30408722081 @default.
- W3040872208 hasRelatedWork W17081240 @default.
- W3040872208 hasRelatedWork W18026406 @default.
- W3040872208 hasRelatedWork W20214030 @default.
- W3040872208 hasRelatedWork W23793184 @default.
- W3040872208 hasRelatedWork W27958817 @default.
- W3040872208 hasRelatedWork W31301531 @default.
- W3040872208 hasRelatedWork W33136280 @default.
- W3040872208 hasRelatedWork W35996398 @default.
- W3040872208 hasRelatedWork W6042099 @default.
- W3040872208 hasRelatedWork W25796273 @default.
- W3040872208 isParatext "false" @default.
- W3040872208 isRetracted "false" @default.
- W3040872208 magId "3040872208" @default.
- W3040872208 workType "article" @default.